Combined effects of soil moisture and microphysical perturbations on convective clouds and precipitation for a locally forced case over Central Europe

To study the combined impact of soil moisture and microphysical perturbations on convective clouds and precipitation over Central Europe, an ensemble of five dozen real-world weather prediction forecasts was conducted with the COnsortium for Small-scale MOdeling (COSMO) model at convection-permitting resolution for a case with weak large-scale forcing (6 June 2016). We find a large sensitivity of precipitation, ranging from +10% to -$$-$$23% in 12-hr precipitation totals. While the homogeneous soil-moisture bias of +/-$$\pm$$25% primarily controls the timing of convection initiation and the amount of surface rainfall, the number of cloud condensation nuclei and width of the cloud droplet size distribution mainly control the number, size, and lifetime of convective clouds. In moisture-limited conditions, mainly positive couplings are acting. Drier soils, cleaner air, and a broader cloud droplet size distribution result in less rainfall. Wetter soils and more polluted conditions lead to fewer, but larger, cloud clusters. Since microphysical process rates depend systematically on the sign of the perturbations, but rainfall does not, there are compensating effects at work that buffer microphysical perturbations directly and impact the cloud condensate amount and the rainfall at the ground

The determinants of the performance of dairy smallholders in Malawi

Milk production in Malawi is stagnating although neighbouring countries steadily increase outputs. In this paper, we explored the determinants of the performance of dairy smallholders. As indicators of on-farm performance we used annual milk yield, calving intervals, and annual dairy income. Regression models revealed that milk yield was negatively related with farmer’s age, female farmer, and household size, but positively influenced by farmers’ experience. Calving intervals were strongly associated with labour costs and breeding method. Income from dairying was only associated with farmers’ education but varied strongly with region. Regional effects existed for all performance indicators which may partly be rooted in land scarcity in the south and the efforts of development agencies to promote dairying in the northern and central regions. Results also revealed a tendency for pure breeds to produce higher outputs, but crossbreeds due to lower costs provided better income. Thus, we recommend that experienced farmers become involved in extension programs to provide comprehensive services that help farmers make more efficient use of their scarce assets, and thus realise more of the animals’ genetic potential with regard to the three observed performance indicators

Reliability of the active knee joint position sense test and influence of limb dominance and sex

The output of a sensorimotor performance can be measured with the joint position sense (JPS) test. However, investigations of leg dominance, sex and quality measures on this test are limited. Therefore, these potential influencing factors as well as reliability and consistency measures were evaluated for angular reproduction performance and neuromuscular activity during the active knee JPS test in healthy participants. Twenty healthy participants (10 males; 10 females; age 29 ± 8 years; height 165 ± 39 cm; body mass 69 ± 13 kg) performed a seated knee JPS test with a target angle of 50°. Measurements were conducted in two sessions separated by two weeks and consisted of two blocks of continuous angular reproduction (three minutes each block). The difference between reproduced and target angle was identified as angular error measured by an electrogoniometer. During reproduction, the neuromuscular activity of the quadriceps muscle was assessed by surface electromyography. Neuromuscular activity was normalized to submaximal voluntary contraction (subMVC) and displayed per muscle and movement phase. Differences between leg dominance and sex were calculated using Friedman-test (α = 0.05). Reliability measures including intraclass correlation coefficient (ICC), Bland–Altman analysis (bias ± limits of agreement (LoA)) and minimal detectable change (MDC) were analysed. No significant differences between leg dominance and sex were found in angular error and neuromuscular activity. Angular error demonstrated inter-session ICC scores of 0.424 with a bias of 2.4° (± 2.4° LoA) as well as MDC of 6.8° and moderate intra-session ICC (0.723) with a bias of 1.4° (± 1.65° LoA) as well as MDC of 4.7°. Neuromuscular activity for all muscles and movement phases illustrated inter-session ICC ranging from 0.432 to 0.809 with biases between − 2.5 and 13.6% subMVC and MDC from 13.4 to 63.9% subMVC. Intra-session ICC ranged from 0.705 to 0.987 with biases of − 7.7 to 2.4% subMVC and MDC of 2.7 to 46.5% subMVC. Leg dominance and sex seem not to influence angular reproduction performance and neuromuscular activity. Poor to excellent relative reliability paired with an acceptable consistency confirm findings of previous studies. Comparisons to pathological populations should be conducted with caution

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival

Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited. We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis. Patients and Methods: Tissue samples were obtained from surgically treated patients. Expression of the EC-cell marker, vesicular monoamine transporter-1 (VMAT-1), was used to verify ileal carcinoids. We investigated the differential expression of MMP-2, 7, 9, 11, and 13 and their endogenous inhibitors (TIMP-1, 2, and 3) by quantitative real-time RT-PCR in 25 primary tumors, their corresponding lymph node metastases and/or liver metastases and matched normal mucosa. Results: Significantly increased expression of VMAT-1, MMP-2, MMP-11, TIMP-1 and TIMP-3 was determined by quantitative RT-PCR in EC-cell carcinoids compared to normal intestinal mucosa (p < 0.05). In contrast, MMP-2 and MMP-9 as well as TIMP-1, TIMP-2, and TIMP-3 expression in primary tumors of patients with liver metastases (M1) was significantly lower than in patients lacking liver metastases (M0). EC-cell tumors were significantly larger in the M1 group of tumors, while VMAT-1 expression was significantly decreased. We found an inverse correlation between tumor size and prognosis. Univariate analysis further revealed that decreased expression of VMAT-1, MMP-2 and TIMP-3 in primary tumors was significantly associated with a reduced survival time of the patients. Conclusion: Our data reveal that MMP-2 and TIMP-3 expression together with VMAT-1 expression are of potential prognostic and clinical value in ileal carcinoids. Copyright (C) 2008 S. Karger AG, Base

Instrumenting Java Bytecode to Replay Execution Traces of Multithreaded Programs

Replay of program executions, that lead to a failure, can help developers to find software faults. While replay of deterministic executions of sequential programs can be easily achieved with existing debuggers, little support exists for deterministic replay of a multithreaded program

Prostate Cancer Nodal Staging: Using Deep Learning to Predict 68Ga-PSMA-Positivity from CT Imaging Alone

Lymphatic spread determines treatment decisions in prostate cancer (PCa) patients. 68Ga-PSMA-PET/CT can be performed, although cost remains high and availability is limited. Therefore, computed tomography (CT) continues to be the most used modality for PCa staging. We assessed if convolutional neural networks (CNNs) can be trained to determine 68Ga-PSMA-PET/CT-lymph node status from CT alone. In 549 patients with 68Ga-PSMA PET/CT imaging, 2616 lymph nodes were segmented. Using PET as a reference standard, three CNNs were trained. Training sets balanced for infiltration status, lymph node location and additionally, masked images, were used for training. CNNs were evaluated using a separate test set and performance was compared to radiologists' assessments and random forest classifiers. Heatmaps maps were used to identify the performance determining image regions. The CNNs performed with an Area-Under-the-Curve of 0.95 (status balanced) and 0.86 (location balanced, masked), compared to an AUC of 0.81 of experienced radiologists. Interestingly, CNNs used anatomical surroundings to increase their performance, "learning" the infiltration probabilities of anatomical locations. In conclusion, CNNs have the potential to build a well performing CT-based biomarker for lymph node metastases in PCa, with different types of class balancing strongly affecting CNN performance

¿Hemisferio occidental dividido? O bien: ¿Hasta dónde llega México?

Una vez más, el hemisferio occidental es objeto de redefiniciones. En las diversas construcciones del espacio, como lo expondremos más claramente abajo, se manifiestan importantes diferencias que resultan de las representaciones que se tengan del hemisferio como un todo común o escindido. En esa controversia corresponde a México, como tierra fronteriza entre el Norte y el Sur, como un mundo intermedio que no es claramente determinable geográficamente, un papel central. ¿Se desplaza del Sur el país –desde 1994 perteneciente al Tratado de Libre Comercio (TLC) de Norteamérica y desde 2002 a la zona militar del Northern Command de EE.UU.– acaparado por Norteamérica, o experimenta Norteamérica una mexicanización (no sólo por los mexicanos), que, como teme Huntington, no sólo transforma el idioma y los hábitos lingüísticos, sino también la cultura, la política, la justicia y el comercio

Incongruent molecular and morphological variation in the crab spider Synema globosum (Araneae, Thomisidae) in Europe

Establishing species boundaries is one of the challenges taxonomists around the world have been tackling for centuries. The relation between intraspecific and interspecific variability is still under discussion and in many taxa it remains understudied. Here the hypothesis of single versus multiple species of the crab spider Synema globosum (Fabricius) is tested. The wide distribution range as well as its high morphological variability makes this species an interesting candidate for re-evaluation using an integrative approach. This study combines information from barcoding, phylogenetic reconstruction based on mitochondrial CO1 and ITS2 of more than 60 specimens collected over a wide range of European localities, and morphology. The findings show deep clades with up to 6% mean pairwise distance in the CO1 barcode without any biogeographical pattern. The nuclear ITS2 gene did not support the CO1 clades. Morphological assessment of somatic and genital characters in males and females and a morphometric analysis of the male palp uncovered high intraspecific variation that does not match the CO1 or ITS2 phylogenies or biogeography either. Screening for endosymbiotic Wolbachia bacteria was conducted and only a single infected specimen was found. Several scenarios might explain these inconsistent patterns. While the deep divergences in the barcoding marker might suggest cryptic or ongoing speciation or geographical isolation in the past, the lack of congruent variation in the nuclear ITS2 gene or the studied morphological character systems, especially the male palp, indicates that S. globosum might simply be highly polymorphic both in terms of its mtDNA and morphology. Therefore, more data on ecology and behaviour and full genome sequences are necessary to ultimately resolve this taxonomically intriguing case