NASA Dryden's UAS Service Capabilities

The vision of NASA s Dryden Flight Research Center is to "fly what others only imagine." Its mission is to advance technology and science through flight. Objectives supporting the mission include performing flight research and technology integration to revolutionize aviation and pioneer aerospace technology, validating space exploration concepts, conducting airborne remote sensing and science missions, and supporting operations of the Space Shuttle and the International Space Station. A significant focus of effort in recent years has been on Unmanned Aircraft Systems (UAS), both in support of the Airborne Science Program and as research vehicles to advance the state of the art in UAS. Additionally, the Center has used its piloted aircraft in support of UAS technology development. In order to facilitate greater access to the UAS expertise that exists at the Center, that expertise has been organized around three major capabilities. The first is access to high-altitude, long-endurance UAS. The second is the establishment of a test range for small UAS. The third is safety case assessment support

UAS Integration into the NAS Project

The goal of the UAS Integration in the NAS Project is to contribute capabilities that reduce technical barriers related to the safety and operational challenges associated with enabling routine UAS access to the NAS This goal will be accomplished through a two-phased approach of system-level integration of key concepts, technologies and/or procedures, and demonstrations of integrated capabilities in an operationally relevant environment. Technical objectives include: PHASE 1: a) Validating the key technical areas identified by this project. System-level analyses, a State of the Art Analysis (SOAA), and a ConOps will identify the challenges and barriers preventing routine UAS access to the NAS. b) Developing a national roadmap and gap analysis identifying specific deliverables in the area of operations, procedures, and technologies that will impact future policy decisions. PHASE 2: a) Provide regulators with a methodology for developing airworthiness requirements for UAS and data to support development of certifications standards and regulatory guidance. b) Provide systems-level integrated testing of concepts and/or capabilities that address barriers to routine access to the NAS. Through simulation and flight testing, address issues including separation assurance, communications requirements, and Pilot Aircraft Interfaces (PAIs) in operationally relevant environment

An Analysis of a New Shoe Technology in The Gait Patterns of a Child with a Neurological Disability

This study focused on the application of a unique technology originally designed to supply biofeedback to dancers, but in this case was used to assist a child learning to walk while battling the effects of Cerebral Palsy. The musical shoes, called ElectroskipTM, utilize a biofeedback system that generates variable sounds/beats/songs when an individual is walking and placing pressure on their heel or toe. The study lasted six weeks with two sessions per week. Each session started with shoes fitted with ElectroskipTM technology placed on the child’s feet. When instructed by the researcher the child would proceed to a size appropriate set of parallel bars to begin the pre-test walking trial. Gripping the parallel bars the child would attempt to complete two passes, back and forth, walking along the 2.4 meter length of the bars. ElectroskipTM and video data from each walking attempt was recorded. The child would then have a free play time followed by a post-test walking trial. While the ElectroskipTM technology was worn for each session to make sure the session routine was consistent for the child, it was only activated every other session. Following each session the number of steps taken during the pre-test and post-test trials recorded with the ElectroskipTM software was compared to the visual information found in the video record. Data indicated that at the end of the study the child was able to walk better, based on a comparison of pre and post study scores from the Test of Gross Motor Development II (TGMD-II) evaluation instrument administered by the director of the SIMs Laboratory on the SUNY Cortland campus

The NASA Dryden Flight Research Center Unmanned Aircraft System Service Capabilities

Over 60 years of Unmanned Aircraft System (UAS) expertise at the NASA Dryden Flight Research Center are being leveraged to provide capability and expertise to the international UAS community. The DFRC brings together technical experts, UAS, and an operational environment to provide government and industry a broad capability to conduct research, perform operations, and mature systems, sensors, and regulation. The cornerstone of this effort is the acquisition of both a Global Hawk (Northrop Grumman Corporation, Los Angeles, California) and Predator B (General Atomics Aeronautical Systems, Inc., San Diego, California) unmanned aircraft system (UAS). In addition, a test range for small UAS will allow developers to conduct research and development flights without the need to obtain approval from civil authorities. Finally, experts are available to government and industry to provide safety assessments in support of operations in civil airspace. These services will allow developers to utilize limited resources to their maximum capability in a highly competitive environment

Icolos: a workflow manager for structure-based post-processing of de novo generated small molecules

A Summary: We present Icolos, a workflow manager written in Python as a tool for automating complex structure-based workflows for drug design. Icolos can be used as a standalone tool, for example in virtual screening campaigns, or can be used in conjunction with deep learning-based molecular generation facilitated for example by REINVENT, a previously published molecular de novo design package. In this publication, we focus on the internal structure and general capabilities of Icolos, using molecular docking experiments as an illustrative example

DockStream: a docking wrapper to enhance de novo molecular design

Recently, we have released the de novo design platform REINVENT in version 2.0. This improved and extended iteration supports far more features and scoring function components, which allows bespoke and tailor-made protocols to maximize impact in small molecule drug discovery projects. A major obstacle of generative models is producing active compounds, in which predictive (QSAR) models have been applied to enrich target activity. However, QSAR models are inherently limited by their applicability domains. To overcome these limitations, we introduce a structure-based scoring component for REINVENT. DockStream is a flexible, stand-alone molecular docking wrapper that provides access to a collection of ligand embedders and docking backends. Using the benchmarking and analysis workflow provided in DockStream, execution and subsequent analysis of a variety of docking configurations can be automated. Docking algorithms vary greatly in performance depending on the target and the benchmarking and analysis workflow provides a streamlined solution to identifying productive docking configurations. We show that an informative docking configuration can inform the REINVENT agent to optimize towards improving docking scores using public data. With docking activated, REINVENT is able to retain key interactions in the binding site, discard molecules which do not fit the binding cavity, harness unused (sub-)pockets, and improve overall performance in the scaffold-hopping scenario. The code is freely available at https://github.com/MolecularAI/DockStream

Meeting of Experts on NASA's Unmanned Aircraft System (UAS) Integration in the National Airspace Systems (NAS) Project

Topics discussed include: Aeronautics Research Mission Directorate Integrated Systems Research Program (ISRP) and UAS Integration in the NAS Project; UAS Integration into the NAS Project; Separation Assurance and Collision Avoidance; Pilot Aircraft Interface Objectives/Rationale; Communication; Certification; and Integrated Tests and Evaluations