Perubahan Konsep Dapur Hunian Akibat Kebutuhan Pengguna pada Perumahan (Studi Kasus : Perumahan Vila Bukit Tidar Malang)

Dapur merupakan salah satu ruang pada hunian yang memiliki peranan penting pada suatu rumah. Berdasar kebiasaan orang Indonesia, umumnya kegiatan memasak di dapur memerlukan waktu sekitar 8 jam perhari sehingga dalam penggunaannya diperlukan Kenyamanan dan kesesuaian dengan kebutuhan pengguna. Fenomena yang terjadi saat ini banyak rumah Perumahan yang melakukan Perubahan pada desain dapur rumahnya. Hal ini mengindikasikan belum terpenuhinya kebutuhan dan belum ada kesesuaian dengan pengguna. Penelitian ini dilakukan pada 12 sampel Perumahan yang mengalami fenomena tersebut dengan metode analisis deskriptif kualitatif. Hal yang diteliti adalah aspek dapur apa saja yang paling banyak mengalami Perubahan dan faktor kebutuhan pengguna apa yang menjadi penyebab terjadinya Perubahan tersebut. Temuan penelitian ini diharapkan dapat menjadi bahan evaluasi dalam perancangan dapur rumah Perumahan bagi developer Perumahan di masa mendatang dan perancangan dapur bagi masyarakat umum, untuk melihat kebutuhan pengguna sebagai faktor pertimbangan dalam perancangan desain dapur

Microstructural and Elemental Characterization of Root Canal Sealers Using FTIR, SEM, and EDS Analysis

Background: Root canal sealers and repair materials should have the desirable physical, chemical, and biological characteristics, and an antibacterial effect if possible. There is little information available on the biocompatibility of new sealers on the market. Fourier transform infrared spectroscopy (FTIR) can offer trustworthy data to examine chemical structures; another technique for revealing the elements in the constituents that may contribute to the cytotoxicity of these sealers is scanning electron microscopy (SEM), with the goal of elemental mapping utilizing energy-dispersive X-ray spectroscopy (EDX). Methodology: All the root canal sealers were mixed as per the manufacturers’ instructions and allowed to set in molds for 24 h. Then, the samples were placed into an incubator (Memmert GmbH + Co. KG, Schwabach, Germany for 72 h, in a moist environment to allow complete chemical setting of the sealers. The organic and inorganic components of the sample were identified using FTIR with the wavelength length in the infra-red region measuring 400–450 nm. The finely crushed samples were coated with gold metal; following that, the sealer samples were examined under a scanning electron microscope (SEM) at 5000×, 10,000×, and 20,000× magnification, followed by energy-dispersive X-ray spectroscopy. Results: The surfaces of BioRoot and DiaRoot sealers revealed a relatively uniform distribution of irregular micro-sized particles aggregated in clusters, with the particle size ranging from 1 to 65 µm and 0.4 to 55 µm, respectively. OneFill, iRoot, and CeraSeal demonstrated irregularly shaped particles with particle sizes of 0.5 to 105 µm, 0.5 to 195 µm, and 0.3 to 68 µm, respectively. The EDX microanalysis revealed that oxygen, calcium, and carbon were found in all the tested sealer materials. Silicone and zirconium were absent in DiaRoot, but DiaRoot contained fluoride and ytterbium. Moreover, aluminum was noted in DiaRoot, One Fill, and CeraSeal, and chloride was only observed in BioRoot. FTIR analysis revealed strong absorption bands at 666 cm−1 and 709 cm−1 in BioRoot. Bands at 739 cm−1, 804 cm−1, 863 cm−1, 898 cm−1, and 1455 cm−1 were observed in DiaRoot. Bands at 736 cm−1 and 873 cm−1 in OneFill suggested the presence of C-H bending. Similarly, bands were observed at 937 cm−1, 885 cm−1, 743 cm−1, and 1455 cm−1 in iRoot, representing C-H stretching. Conclusions: All root canal sealers had diverse surface morphologies that contained irregular, micro-sized particles that were uniformly distributed, and they lacked heavy metals. All the experimental sealers comprised mainly calcium, oxygen, and carbon

FORMULATION AND OPTIMIZATION OF NATURAL GUM BASED EXTENDED RELEASE TABLETS OF LOSARTAN USING D-OPTIMAL MIXTURE DESIGN

Objective: Losartan potassium is one of the widely prescribed antihypertensive drugs administered orally and its extended-release tablet formulations are essentially required for the long-acting effect at reduced dosage frequency. The present research was aimed for the development and optimization of an extended-release tablet of losartan potassium, exploring natural gums, i.e., xanthan gum and guar gum as drug release modifiers. Methods: The tablet formulation was prepared by wet granulation method and the formulation optimization was done by D-optimal mixture design using Design Expert® software. The independent variables studied were xanthan gum (X1), guar gum (X2) and lactose (X3) taking various combinations of the total amount of gum and ratio of xanthan gum to guar gum under the given constraint range. The dependent (response) variables studied were % drug release in 1h (Y1), 4h (Y2), 7h (Y3) and 10h (Y4). The developed tablets were evaluated for physical properties, i.e., hardness, friability, weight variation as well as the in vitro drug release profiles. For optimization studies, the polynomial equations and response surface plots were generated and the optimized formulation was selected on the basis of maximum desirability value. Results: The developed tablet formulation was found to possess all physical properties within the desired range and showed sustained release profile with ~80% drug release in 10 h duration. The model fitting studies demonstrated best fit in the zero-order model and the slope value of Korsmeyer–Peppas plot was ˃0.89, suggesting case II transport as a drug release mechanism. Conclusion: The findings suggested that natural gums-based matrix tablets of losartan could be successfully developed and natural gums can be explored as platform technology as release retardants and in the development of sustained-release matrix tablets of other drugs

Synchronization of Discrete-Time Fractional-Order Complex-Valued Neural Networks with Distributed Delays

This research investigates the synchronization of distributed delayed discrete-time fractional-order complex-valued neural networks. The necessary conditions have been established for the stability of the proposed networks using the theory of discrete fractional calculus, the discrete Laplace transform, and the theory of fractional-order discrete Mittag–Leffler functions. In order to guarantee the global asymptotic stability, adequate criteria are determined using Lyapunov’s direct technique, the Lyapunov approach, and some novel analysis techniques of fractional calculation. Thus, some sufficient conditions are obtained to guarantee the global stability. The validity of the theoretical results are finally shown using numerical examples

The Dynamical Behavior of a Three-Dimensional System of Exponential Difference Equations

The boundedness nature and persistence, global and local behavior, and rate of convergence of positive solutions of a second-order system of exponential difference equations, is investigated in this work. Where the parameters A,B,C,α,β,γ,δ,η, and ξare constants that are positive, and the initials U−1,U0,V−1,V0,W−1, and W0 are non-negative real numbers. Some examples are provided to support our theoretical results

Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing : results from International LBBAP Collaborative Study Group

BACKGROUND: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is effective in patients with heart failure, left bundle branch block (LBBB) and reduced left ventricular function. Left bundle branch area pacing (LBBAP) has been reported as an alternative option for CRT. OBJECTIVE: The aim of this study was to assess the feasibility and outcomes of LBBAP in patients who failed conventional BVP due to coronary venous lead complications or were non-responders to BVP. METHODS: At 16 international centers, LBBAP was attempted in patients with conventional CRT indication who failed BVP due to either, coronary venous (CV) lead complications, or lack of therapeutic response to BVP. We are reporting heart failure hospitalizations (HFH) and death, echocardiographic outcomes, procedural data, pacing parameters, and lead complications including CV lead failure. RESULTS: LBBAP was successfully performed in 200 patients (CV lead failures-156; non-responders-44): age 68±11years, female-35%, LBBB-55%, RVP-23%, ischemic cardiomyopathy-28%, nonischemic cardiomyopathy-63%, LVEF ≤35% in 80%. Procedure and fluoroscopy duration were 119.5±59.6 and 25.7±18.5 min. LBBAP threshold and R-wave amplitudes were 0.68±[email protected] and 10.4±5mV at implant and remained stable during mean follow-up of 12±10.1 months. LBBAP resulted in significant QRS narrowing from 170±28ms to 139±25ms (p<0.001) with V6 R-wave peak times of 85±17ms. LVEF improved from 29±10% at baseline to 40±12% (p<0.001) during follow-up. The risk for death or HFH was lower in CV lead failure compared to non-responders (HR-0.357;95%CI 0.168-0.756,p=0.007) CONCLUSION: LBBAP is a viable alternative for CRT in patients who failed conventional BVP due to CV lead failure or were non-responders