Approaching rice domestication in South Asia: New evidence from Indus settlements in northern India.

The nature and timing of rice domestication and the development of rice cultivation in South Asia is much debated. In northern South Asia there is presently a significant gap (c.4200 years) between earliest evidence for the exploitation of wild rice (Lahuradewa c.6000 BCE) and earliest dated evidence for the utilisation of fully domesticated rice (Mahagara c.1800 BCE). The Indus Civilisation (c.3000-1500 BCE) developed and declined during the intervening period, and there has been debate about whether rice was adopted and exploited by Indus populations during this 'gap'. This paper presents new analysis of spikelet bases and weeds collected from three Indus Civilisation settlements in north-west India, which provide insight into the way that rice was exploited. This analysis suggests that starting in the period before the Indus urban phase (Early Harappan) and continuing through the urban (Mature Harappan/Harappan), post-urban (Late Harappan) and on into the post-Indus Painted Grey Ware (PGW) period, there was a progressive increase in the proportion of domesticated-type spikelet bases and a decrease in wild-types. This pattern fits with a model of the slow development of rice exploitation from wild foraging to agriculture involving full cultivation. Importantly, the accompanying weeds show no increased proportions of wetland species during this period. Instead a mix of wetland and dryland species was identified, and although these data are preliminary, they suggest that the development of an independent rice tradition may have been intertwined with the practices of the eastern most Indus peoples. These data also suggest that when fully domesticated Oryza sativa ssp. japonica was introduced around 2000 BCE, it arrived in an area that was already familiar with domesticated rice cultivation and a range of cultivation techniques.This research was carried out as part of JB's PhD research funded by the Arts and Humanities Research Council, in the GPR laboratory in the McDonald Institute for Archaeological Research, University of Cambridge. Samples were provided by the Land, Water and Settlement project, which was co-directed by CAP and RNS, and is part of a collaboration between the University of Cambridge and Banaras Hindu University, which has operated with the support of the Archaeological Survey of India. The project was funded by the UK India Education Research Initiative, British Academy Stein Arnold Fund, Isaac Newton Trust, McDonald Institute for Archaeological Research and the Research Councils UK. Additional fieldwork funding for JB was provided by the AHRC, Rouse-Ball Research Fund, Cambridge India Partnership Fund, Division of Archaeology Fieldwork Fund and Trinity College Projects Fund.This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Elsevier

Feeding ancient cities in South Asia: Dating the adoption of rice, millet and tropical pulses in the Indus civilisation

© Antiquity Publications Ltd, 2016.The first direct absolute dates for the exploitation of several summer crops by Indus populations are presented here. These include rice, millets and three tropical pulse species at two settlements in the hinterland of the urban site of Rakhigarhi. The dates confirm the role of native summer domesticates in the rise of Indus cities. They demonstrate that, from their earliest phases, a range of crops and variable strategies, including multi-cropping, were used to feed different urban centres. This has important implications for understanding the development of the earliest cities in South Asia, particularly the organisation of labour and provisioning throughout the year.UK India Education and Research Initiative (Standard Award), British Academy (Stein Arnold Fund and International Mobility Scheme), Isaac Newton Trust, McDonald Institute for Archaeological Research, Natural Environment Research Council (NERC Radiocarbon Facility (Project IDs: NF/2009/2/7, NF/2013/1/6)), Arts and Humanities Research Council (Studentship), Trinity College (University of Cambridge), Division of Archaeology, Department of Archaeology and Anthropology (University of Cambridge

'Multi-cropping', Intercropping and Adaptation to Variable Environments in Indus South Asia.

Past human populations are known to have managed crops in a range of ways. Various methods can be used, singly or in conjunction, to reconstruct these strategies, a process which lends itself to the exploration of socio-economic and political themes. This paper endeavours to unpack the concept of 'multi-cropping' by considering diversity and variation in the cropping practices of the populations of South Asia's Indus Civilisation. It argues that nuanced interpretations of the evidence provided by the combinations of crop seeds and weeds present in specific contexts and phases of occupation can reveal much about Indus cropping strategies, which in turn enables consideration of issues related to adaptation, intensification and resilience in the face of changing social, political, economic and environmental climates.Arts and Humanities Research Council, UK India Education and Research Initiative (Standard Award), British Academy (Stein Arnold Fund), Isaac Newton Trust, McDonald Institute for Archaeological Research, Natural Environment Research Council (NERC), European Research Council (ERC) (Consolidator Grant

Cereals, calories and change: exploring approaches to quantification in Indus archaeobotany

Several major cereal groups have been identified as staples used by the pre-urban, urban and post-urban phase populations of the Indus Civilisation (3200–1500 BCE): wheat, barley, a range of small hulled millets and also rice, though their proportional exploitation is variable across space and over time. Traditional quantification methods examine the frequency, intensity and proportionality of the use of these crops and help ascertain the ‘relative importance’ of these cereals for Indus populations. However, this notion of ‘importance’ is abstracted from the daily lives of the people using these crops and may be biased by the differential production (as well as archaeological survival) of individual cereals. This paper outlines an alternative approach to quantifying Indus cereals by investigating proportions of calories. Cereals are predominantly composed of carbohydrates and therefore provided much of the daily caloric intake among many late Holocene farming populations. The four major cereal groups cultivated by Indus farmers, however, vary greatly in terms of calories per grain, and this has an impact on their proportional input to past diets. This paper demonstrates that, when converted to proportions of calories, the perceived ‘importance’ of cereals from five Indus sites changes dramatically, reducing the role of the previously dominant small hulled millet species and elevating the role of Triticoid grains. Although other factors will also have affected how a farmer perceived the role and importance of a crop, including its ecological tolerances, investments required to grow it, and the crop’s role in the economy, this papers suggests that some consideration of what cereals meant in terms of daily lives is needed alongside the more abstracted quantification methods that have traditionally been applied.This research was carried out as a part of JB’s PhD research, which was funded by the Arts and Humanities Research Council. Analysis was carried out in the George Pitt Rivers laboratory in the McDonald Institute for Archaeological Research, University of Cambridge. Samples were provided by the Land, Water, Settlement project, co-directed by CAP and RNS, which is a collaboration between the University of Cambridge and Banaras Hindu University that was carried out with the support of the Archaeological Survey of India. The Land, Water, Settlement project was funded by the UK India Education Research Initiative, British Academy Stein Arnold Fund, Isaac Newton Trust, McDonald Institute for Archaeological Research and the Research Councils UK. Additional fieldwork funding for JB was provided by the Arts and Humanities Research Council, Rouse-Ball Research Fund, Cambridge India Partnership Fund, Division of Archaeology Fieldwork Fund and Trinity College Projects Fund

Measuring hospital-wide activity volume for patient safety and infection control: a multi-centre study in Japan

<p>Abstract</p> <p>Background</p> <p>In Japan, as in many other countries, several quality and safety assurance measures have been implemented since the 1990's. This has occurred in spite of cost containment efforts. Although government and hospital decision-makers demand comprehensive analysis of these activities at the hospital-wide level, there have been few studies that actually quantify them. Therefore, the aims of this study were to measure hospital-wide activities for patient safety and infection control through a systematic framework, and to identify the incremental volume of these activities implemented over the last five years.</p> <p>Methods</p> <p>Using the conceptual framework of incremental activity corresponding to incremental cost, we defined the scope of patient safety and infection control activities. We then drafted a questionnaire to analyze these realms. After implementing the questionnaire, we conducted several in-person interviews with managers and other staff in charge of patient safety and infection control in seven acute care teaching hospitals in Japan.</p> <p>Results</p> <p>At most hospitals, nurses and clerical employees acted as the main figures in patient safety practices. The annual amount of activity ranged from 14,557 to 72,996 person-hours (per 100 beds: 6,240; per 100 staff: 3,323) across participant hospitals. Pharmacists performed more incremental activities than their proportional share. With respect to infection control activities, the annual volume ranged from 3,015 to 12,196 person-hours (per 100 beds: 1,141; per 100 staff: 613). For infection control, medical doctors and nurses tended to perform somewhat more of the duties relative to their share.</p> <p>Conclusion</p> <p>We developed a systematic framework to quantify hospital-wide activities for patient safety and infection control. We also assessed the incremental volume of these activities in Japanese hospitals under the reimbursement containment policy. Government and hospital decision makers can benefit from this type of analytic framework and its empirical findings.</p

Investigating the running abilities of Tyrannosaurus rex using stress-constrained multibody dynamic analysis

The running ability of Tyrannosaurus rex has been intensively studied due to its relevance to interpretations of feeding behaviour and the biomechanics of scaling in giant predatory dinosaurs. Different studies using differing methodologies have produced a very wide range of top speed estimates and there is therefore a need to develop techniques that can improve these predictions. Here we present a new approach that combines two separate biomechanical techniques (multibody dynamic analysis and skeletal stress analysis) to demonstrate that true running gaits would probably lead to unacceptably high skeletal loads in T. rex. Combining these two approaches reduces the high-level of uncertainty in previous predictions associated with unknown soft tissue parameters in dinosaurs, and demonstrates that the relatively long limb segments of T. rex—long argued to indicate competent running ability—would actually have mechanically limited this species to walking gaits. Being limited to walking speeds contradicts arguments of high-speed pursuit predation for the largest bipedal dinosaurs like T. rex, and demonstrates the power of multiphysics approaches for locomotor reconstructions of extinct animals

Maternal allergic contact dermatitis causes increased asthma risk in offspring

<p>Abstract</p> <p>Background</p> <p>Offspring of asthmatic mothers have increased risk of developing asthma, based on human epidemiologic data and experimental animal models. The objective of this study was to determine whether maternal allergy at non-pulmonary sites can increase asthma risk in offspring.</p> <p>Methods</p> <p>BALB/c female mice received 2 topical applications of vehicle, dinitrochlorobenzene, or toluene diisocyanate before mating with untreated males. Dinitrochlorobenzene is a skin-sensitizer only and known to induce a Th1 response, while toluene diisocyanate is both a skin and respiratory sensitizer that causes a Th2 response. Both cause allergic contact dermatitis. Offspring underwent an intentionally suboptimal protocol of allergen sensitization and aerosol challenge, followed by evaluation of airway hyperresponsiveness, allergic airway inflammation, and cytokine production. Mothers were tested for allergic airway disease, evidence of dermatitis, cellularity of the draining lymph nodes, and systemic cytokine levels. The role of interleukin-4 was also explored using interleukin-4 deficient mice.</p> <p>Results</p> <p>Offspring of toluene diisocyanate but not dinitrochlorobenzene-treated mothers developed an asthmatic phenotype following allergen sensitization and challenge, seen as increased Penh values, airway inflammation, bronchoalveolar lavage total cell counts and eosinophilia, and Th2 cytokine imbalance in the lung. Toluene diisocyanate treated interleukin-4 deficient mothers were able to transfer asthma risk to offspring. Mothers in both experimental groups developed allergic contact dermatitis, but not allergic airway disease.</p> <p>Conclusion</p> <p>Maternal non-respiratory allergy (Th2-skewed dermatitis caused by toluene diisocyanate) can result in the maternal transmission of asthma risk in mice.</p

Cost-effectiveness of ward-based pharmacy care in surgical patients: protocol of the SUREPILL (Surgery & Pharmacy In Liaison) study

<p>Abstract</p> <p>Background</p> <p>Preventable adverse drug events (pADEs) are widely known to be a health care issue for hospitalized patients. Surgical patients are especially at risk, but prevention of pADEs in this population is not demonstrated before. Ward-based pharmacy interventions seem effective in reducing pADEs in medical patients. The cost-effectiveness of these preventive efforts still needs to be assessed in a comparative study of high methodological standard and also in the surgical population. For these aims the SUREPILL (Surgery & Pharmacy in Liaison) study is initiated.</p> <p>Methods/Design</p> <p>A multi-centre controlled trial, with randomisation at ward-level and preceding baseline assessments is designed. Patients admitted to the surgical study wards for elective surgery with an expected length of stay of more than 48 hours will be included. Patients admitted to the intervention ward, will receive ward-based pharmacy care from the clinical pharmacy team, i.e. pharmacy practitioners and hospital pharmacists. This ward-based pharmacy intervention includes medication reconciliation in consultation with the patient at admission, daily medication review with face-to-face contact with the ward doctor, and patient counselling at discharge. Patients admitted in the control ward, will receive standard pharmaceutical care.</p> <p>The primary clinical outcome measure is the number of pADEs per 100 elective admissions. These pADEs will be measured by systematic patient record evaluation using a trigger tool. Patient records positive for a trigger will be evaluated on causality, severity and preventability by an independent expert panel. In addition, an economic evaluation will be performed from a societal perspective with the costs per preventable ADE as the primary economic outcome. Other outcomes of this study are: severity of pADEs, number of patients with pADEs per total number of admissions, direct (non-)medical costs and indirect non-medical costs, extra costs per prevented ADE, number and type of pharmacy interventions, length of hospital stay, complications registered in a national complication registration system for surgery, number of readmissions within three months after initial admission (follow-up), quality of life and number of non-institutionalized days during follow-up.</p> <p>Discussion</p> <p>This study will assess the cost-effectiveness of ward-based pharmacy care on preventable adverse drug events in surgical patients from a societal perspective, using a comparative study design.</p> <p>Trial registration</p> <p>Netherlands Trial Register (NTR): <a href="http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2258">NTR2258</a></p