RINGO2: an EMCCD-based polarimeter for GRB followup

We describe the design and construction of a new novel optical polarimeter (RINGO2) for the Liverpool Telescope. The instrument is designed for rapid (< 3 minute) followup observations of Gamma Ray Bursts in order to measure the early time polarization and time evolution on timescales of ~ 1 - 10000 seconds. By using a fast rotating Polaroid whose rotation is synchronized to control the readout of an electron multiplying CCD eight times per revolution, we can rebin our data in the time domain after acquisition with little noise penalty, thereby allowing us to explore the polarization evolution of these rapidly variable objects for the first time. © (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only

RINGO3: a multi-colour fast response polarimeter

GRB jets contain rapidly moving electrons which will spiral around magnetic field lines. This causes them to emit polarized synchrotron emission. We have built a series of polarimeters (RINGO and RINGO2) to investigate this by measuring the polarization of optical light from GRBs at a certain single wavelength. The instruments are mounted on the Liverpool Telescope, which is a fully robotic (i.e. unmanned) telescope on La Palma which reacts to triggers from satellites such as the NASA SWIFT mission. This has had great success, with the first ever detections of early time optical polarization being made. In addition, the first measurements of the change in optical polarization from a GRB as the jet expands have recently been obtained. In this paper we describe the design and construction of RINGO3. This will be a multi-colour instrument that can observe simultaneously at three wavelengths. By doing so we will be able to unambiguously identify where in the burst the polarized emission is coming from. This will allow us to distinguish between three possibilities: (1) Magnetic instabilities generated in the shock front, (2) Line of sight effects and (3) Large-scale magnetic fields present throughout the relativistic outflow. The instrument design combines a rapidly rotating polaroid, specially designed polarization insensitive dichroic mirrors and three electron multiplying CCD cameras to provide simultaneous wavelength coverage with a time resolution of 1 second

IO:I, a near-infrared camera for the Liverpool Telescope

IO:I is a new instrument that has recently been commissioned for the Liverpool Telescope, extending current imaging capabilities beyond the optical and into the near-infrared. Cost has been minimized by the use of a previously decommissioned instrument's cryostat as the base for a prototype and retrofitting it with Teledyne's 1.7-μm cutoff Hawaii-2RG HgCdTe detector, SIDECAR ASIC controller, and JADE2 interface card. The mechanical, electronic, and cryogenic aspects of the cryostat retrofitting process will be reviewed together with a description of the software/hardware setup. This is followed by a discussion of the results derived from characterization tests, including measurements of read noise, conversion gain, full well depth, and linearity. The paper closes with a brief overview of the autonomous data reduction process and the presentation of results from photometric testing conducted on on-sky, pipeline processed data. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

SPRAT: Spectrograph for the Rapid Acquisition of Transients

We describe the development of a low cost, low resolution (R ~ 350), high throughput, long slit spectrograph covering visible (4000-8000) wavelengths. The spectrograph has been developed for fully robotic operation with the Liverpool Telescope (La Palma). The primary aim is to provide rapid spectral classification of faint (V ∼ 20) transient objects detected by projects such as Gaia, iPTF (intermediate Palomar Transient Factory), LOFAR, and a variety of high energy satellites. The design employs a volume phase holographic (VPH) transmission grating as the dispersive element combined with a prism pair (grism) in a linear optical path. One of two peak spectral sensitivities are selectable by rotating the grism. The VPH and prism combination and entrance slit are deployable, and when removed from the beam allow the collimator/camera pair to re-image the target field onto the detector. This mode of operation provides automatic acquisition of the target onto the slit prior to spectrographic observation through World Coordinate System fitting. The selection and characterisation of optical components to maximise photon throughput is described together with performance predictions. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Non-dimensional Newton-Puiseux Expansions

Recent results in the theory and application of Newton-Puiseux expansions, i.e. fractional power series solutions of equations, suggest further developments within a more abstract algebraic-geometric framework, involving in particular the theory of toric varieties and ideals. Here, we present a number of such developments, especially in relation to the equations of van der Pol, Riccati, and Schrödinger. Some pure mathematical concepts we are led to are Graver, Gröbner, lattice and circuit bases, combinatorial geometry and differential algebra, and algebraic-differential equations. Two techniques are coordinated: classical dimensional analysis (DA) in applied mathematics and science, and a polynomial and differential-polynomial formulation of asymptotic expansions, referred to here as Newton-Puiseux (NP) expansions. The latter leads to power series with rational exponents, which depend on the choice of the dominant part of the equations, often referred to as the method of "dominant balance". The paper shows, using a new approach to DA based on toric ideals, how dimensionally homogeneous equations may best be non-dimensionalised, and then, with examples involving differential equations, uses recent work on NP expansions to show how non-dimensional parameters affect the results. Our approach finds a natural home within computational algebraic geometry, i.e. at the interface of abstract and algorithmic mathematics

Creating clinical pharmacy capacity in Namibia: a collaboration to establish a post-graduate pharmacy degree programme

Namibia has previously relied on external training of pharmacists but began in-country training in 2011. In response to an identified need for postgraduate clinical pharmacy development and training in the country, a Master’s degree was set up at the University of Namibia in 2016. The country has a considerable health burden of HIV and TB as well as a shortage of healthcare professionals. A UK clinical diploma model was adapted to meet the specific needs of the country and wider region, ensuring students could access the course over a sparsely populated, but large geographical spread, in addition to providing work-based learning, embedding research skills for future development, and focusing on the health needs of Namibia. The course uses online learning platforms and contact sessions to cover both knowledge and skill acquisition throughout the 3 years of the course. UK and US clinical pharmacists are utilised to provide specialist input, both remotely and within student workplaces, and further support has come from collaborations, including cross-site visits, with the UK-based pharmacy school whose diploma model was adapted. Challenges have included a shortage of clinical mentors, also compounding the students’ difficulty in visualising their future roles, as well as lone practitioners finding it hard to attend all contact sessions. The initial dropout rates of earlier cohorts have since reduced with greater understanding of the programme, and enthusiasm for the course remains high. The aim for the Master’s is to train students to become competent clinical pharmacists, thus having the knowledge and skills to mentor future cohorts of the course, as well as expanding the specialty within the country

‘Warning: allergic to penicillin’: association between penicillin allergy status in 2.3 million NHS general practice electronic health records, antibiotic prescribing and health outcomes

Background The prevalence of reported penicillin allergy (PenA) and the impact these records have on health outcomes in the UK general population are unknown. Without such data, justifying and planning enhanced allergy services is challenging. Objectives To determine: (i) prevalence of PenA records; (ii) patient characteristics associated with PenA records; and (iii) impact of PenA records on antibiotic prescribing/health outcomes in primary care. Methods We carried out cross-sectional/retrospective cohort studies using patient-level data from electronic health records. Cohort study: exact matching across confounders identified as affecting PenA records. Setting: English NHS general practices between 1 April 2013 and 31 March 2014. Participants: 2.3 million adult patients. Outcome measures: prevalence of PenA, antibiotic prescribing, mortality, MRSA infection/colonization and Clostridioides difficile infection. Results PenA prevalence was 5.9% (IQR = 3.8%–8.2%). PenA records were more common in older people, females and those with a comorbidity, and were affected by GP practice. Antibiotic prescribing varied significantly: penicillins were prescribed less frequently in those with a PenA record [relative risk (RR)  = 0.15], and macrolides (RR = 4.03), tetracyclines (RR = 1.91) nitrofurantoin (RR = 1.09), trimethoprim (RR = 1.04), cephalosporins (RR = 2.05), quinolones (RR = 2.10), clindamycin (RR = 5.47) and total number of prescriptions were increased in patients with a PenA record. Risk of re-prescription of a new antibiotic class within 28 days (RR = 1.32), MRSA infection/colonization (RR = 1.90) and death during the year subsequent to 1 April 2013 (RR = 1.08) increased in those with PenA records. Conclusions PenA records are common in the general population and associated with increased/altered antibiotic prescribing and worse health outcomes. We estimate that incorrect PenA records affect 2.7 million people in England. Establishing true PenA status (e.g. oral challenge testing) would allow more people to be prescribed first-line antibiotics, potentially improving health outcomes

Vitamin D and subsequent all-age and premature mortality: a systematic review

&lt;br&gt;Background: All-cause mortality in the population &#60; 65 years is 30% higher in Glasgow than in equally deprived Liverpool and Manchester. We investigated a hypothesis that low vitamin D in this population may be associated with premature mortality via a systematic review and meta-analysis.&lt;/br&gt; &lt;br&gt;Methods: Medline, EMBASE, Web of Science, the Cochrane Library and grey literature sources were searched until February 2012 for relevant studies. Summary statistics were combined in an age-stratified meta-analysis.&lt;/br&gt; &lt;br&gt;Results: Nine studies were included in the meta-analysis, representing 24,297 participants, 5,324 of whom died during follow-up. The pooled hazard ratio for low compared to high vitamin D demonstrated a significant inverse association (HR 1.19, 95% CI 1.12-1.27) between vitamin D levels and all-cause mortality after adjustment for available confounders. In an age-stratified meta-analysis, the hazard ratio for older participants was 1.25 (95% CI 1.14-1.36) and for younger participants 1.12 (95% CI 1.01-1.24).&lt;/br&gt; &lt;br&gt;Conclusions: Low vitamin D status is inversely associated with all-cause mortality but the risk is higher amongst older individuals and the relationship is prone to residual confounding. Further studies investigating the association between vitamin D deficiency and all-cause mortality in younger adults with adjustment for all important confounders (or using randomised trials of supplementation) are required to clarify this relationship.&lt;/br&gt

RINGO: a novel ring polarimeter for rapid GRB followup - art. no. 62695M

We describe the design and construction of a novel optical ring-polarimeter (RINGO) for the Liverpool Telescope. The instrument is designed for rapid (< 5 minutes) followup observations of Gamma Ray Bursts in order to measure the early time polarization and its evolution for the first time. Sensitivity calculations and data reduction procedures are described, and the results of on-sky commissioning presented. The instrument is now on the telescope and in routine use during GRB followup. © (2006) COPYRIGHT SPIE--The International Society for Optical Engineering

LOTUS: a low-cost, ultraviolet spectrograph

We describe the design, construction and commissioning of a simple, low-cost long-slit spectrograph for the Liverpool Telescope. The design is optimized for near-UV and visible wavelengths and uses all transmitting optics. It exploits the instrument focal plane field curvature to partially correct axial chromatic aberration. A stepped slit provides narrow (2.5 × 95 arcsec) and wide (5 × 25 arcsec) options that are optimized for spectral resolution and flux calibration, respectively. On sky testing shows a wavelength range of 3200–6300 Å with a peak system throughput (including detector quantum efficiency) of 15 per cent and wavelength dependent spectral resolution of R = 225–430. By repeated observations of the symbiotic emission line star AG Peg, we demonstrate the wavelength stability of the system is <2 Å rms and is limited by the positioning of the object in the slit. The spectrograph is now in routine operation monitoring the activity of comet 67P/Churyumov-Gerasimenko during its current post-perihelion apparition