7,112 research outputs found
Representations and Properties of Generalized Statistics
A generalization of statistics is proposed and developed. The
generalized quantum statistics is completely specified by a set of
Jacobson generators satisfying a set of triple algebraic relations.
Fock-Hilbert representations and Bargmann-Fock realizations are derived.Comment: 12 pages, to appear in IJMPA (2006
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Brainstem atrophy in focal epilepsy destabilizes brainstem-brain interactions: Preliminary findings.
BACKGROUND: MR Imaging has shown atrophy in brainstem regions that were linked to autonomic dysfunction in epilepsy patients. The brainstem projects to and modulates the activation state of several wide-spread cortical/subcortical regions. The goal was to investigate 1. Impact of brainstem atrophy on gray matter connectivity of cortical/subcortical structures and autonomic control. 2. Impact on the modulation of cortical/subcortical functional connectivity.
METHODS: 11 controls and 18 patients with non-lesional focal epilepsy (FE) underwent heart rate variability (HRV) measurements and a 3 T MRI (T1 in all subjects, task-free fMRI in 7 controls/ 12 FE). The brainstem was extracted, and atrophy assessed using deformation-based-morphometry. The age-corrected z-scores of the mean Jacobian determinants were extracted from 71 5x5x5 mm grids placed in brainstem regions associated with autonomic function. Cortical and non-brainstem subcortical gray matter atrophy was assessed with voxel-based-morphometry and mean age corrected z-scores of the modulated gray matter volumes extracted from 380 cortical/subcortical rois. The profile similarity index was used to characterize the impact of brainstem atrophy on gray matter connectivity. The fMRI was preprocessed in SPM12/Conn17 and the BOLD signal extracted from 398 ROIs (16 brainstem). A dynamic task-free analysis approach was used to identify activation states. Connectivity HRV relationship were assessed with Spearman rank correlations.
RESULTS: HRV was negatively correlated with reduced brainstem right hippocampus/parahippocampus gray matter connectivity in controls (p \u3c .05, FDR) and reduced brainstem to right parietal cortex, lingual gyrus, left hippocampus/amygdala, parahippocampus, temporal pole, and bilateral anterior thalamus connectivity in FE (p \u3c .05, FDR). Dynamic task-free fMRI analysis identified 22 states. The strength of the functional brainstem/cortical connectivity of state 15 was negatively associated with HRV (r = -0.5, p = .03) and positively with decreased brainstem-cortical (0.49, p = .03) gray matter connectivity.
CONCLUSION: The findings of this small pilot study suggest that impaired brainstem-cortex gray matter connectivity in FE negatively affects the brainstem\u27s ability to control cortical activation
Virtual patient design : exploring what works and why : a grounded theory study
Objectives:
Virtual patients (VPs) are online representations of clinical cases used in medical education. Widely adopted, they are well placed to teach clinical reasoning skills. International technology standards mean VPs can be created, shared and repurposed between institutions. A systematic review has highlighted the lack of evidence to support which of the numerous VP designs may be effective, and why. We set out to research the influence of VP design on medical undergraduates.
Methods:
This is a grounded theory study into the influence of VP design on undergraduate medical students. Following a review of the literature and publicly available VP cases, we identified important design properties. We integrated them into two substantial VPs produced for this research. Using purposeful iterative sampling, 46 medical undergraduates were recruited to participate in six focus groups. Participants completed both VPs, an evaluation and a 1-hour focus group discussion. These were digitally recorded, transcribed and analysed using grounded theory, supported by computer-assisted analysis. Following open, axial and selective coding, we produced a theoretical model describing how students learn from VPs.
Results:
We identified a central core phenomenon designated ‘learning from the VP’. This had four categories: VP Construction; External Preconditions; Student–VP Interaction, and Consequences. From these, we constructed a three-layer model describing the interactions of students with VPs. The inner layer consists of the student's cognitive and behavioural preconditions prior to sitting a case. The middle layer considers the VP as an ‘encoded object’, an e-learning artefact and as a ‘constructed activity’, with associated pedagogic and organisational elements. The outer layer describes cognitive and behavioural change.
Conclusions:
This is the first grounded theory study to explore VP design. This original research has produced a model which enhances understanding of how and why the delivery and design of VPs influence learning. The model may be of practical use to authors, institutions and researchers
Mass as a Relativistic Quantum Observable
A field state containing photons propagating in different directions has a
non vanishing mass which is a quantum observable. We interpret the shift of
this mass under transformations to accelerated frames as defining space-time
observables canonically conjugated to energy-momentum observables. Shifts of
quantum observables differ from the predictions of classical relativity theory
in the presence of a non vanishing spin. In particular, quantum redshift of
energy-momentum is affected by spin. Shifts of position and energy-momentum
observables however obey simple universal rules derived from invariance of
canonical commutators.Comment: 5 pages, revised versio
Fast-slow asymptotic for semi-analytical ignition criteria in FitzHugh-Nagumo system
We study the problem of initiation of excitation waves in the FitzHugh-Nagumo
model. Our approach follows earlier works and is based on the idea of
approximating the boundary between basins of attraction of propagating waves
and of the resting state as the stable manifold of a critical solution. Here,
we obtain analytical expressions for the essential ingredients of the theory by
singular perturbation using two small parameters, the separation of time scales
of the activator and inhibitor, and the threshold in the activator's kinetics.
This results in a closed analytical expression for the strength-duration curve.Comment: 10 pages, 5 figures, as accepted to Chaos on 2017/06/2
Mortality study of 18 000 patients treated with omeprazole.
Background: The long term safety of potent gastric acid suppressive therapy has yet to be established.
Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the UK National Health Service Central Registers in 17 936 patients prescribed omeprazole in 1993–1995. Death rates were compared with general population rates.
Results: Records of 17 489 patients (97.5%) were examined. A total of 12 703 patients received further scripts for antisecretory drugs, 8097 for omeprazole only (65.6%): 3097 patients have died. All cause mortality was higher in the first year (observed/expected (O/E) 1.44 (95% confidence intervals (CI) 1.34–1.55); p<0.0001) but had fallen to population expectation by the fourth year. There were significant mortality increases in the first year, falling to or below population expectation by the fourth year, for deaths ascribed to neoplasms (1.82 (95% CI 1.58–2.08); p<0.0001), circulatory diseases (1.27 (95% CI 1.13–1.43); p<0.0001), and respiratory diseases (1.37 (95% CI 1.12–1.64); p<0.001). Increased mortality ascribed to digestive diseases (2.56 (95% CI 1.87–3.43); p<0.0001) persisted, although reduced. Increased mortality rates for cancers of the stomach (4.06 (95% CI 2.60–6.04); p<0.0001), colon and rectum (1.40 (95% CI 0.84–2.18); p=0.075), and trachea, bronchus, and lung (1.64 (95% CI 1.19–2.19); p<0.01) seen in the first year had disappeared by the fourth year but that for cancer of the oesophagus had not (O/E 7.35 (95% CI 5.20–10.09) (p<0.0001) in year 1; 2.88 (95% CI 1.62–4.79) (p<0.001) in year 4). Forty of 78 patients dying of oesophageal cancer had the disease present at registration. Twenty seven of those remaining cases had clinical evidence of Barrett’s disease, stricture, ulcer, or oesophagitis at registration (O/E 3.30 (95% CI 2.17–4.80)). Six deaths occurred in patients with hiatal hernia or reflux only (O/E 1.02 (95% CI 0.37–2.22)) and five in patients without oesophageal disease (O/E 0.77 (95% CI 0.25–1.80)). No relationships were detected with numbers of omeprazole scripts received.
Conclusions: Increases in mortality associated with treatment are due to pre- existing illness, including pre-existing severe oesophageal disease. There was no evidence of an increased risk of oesophageal adenocarcinoma in those without oesophageal mucosal damage recorded at registration
Comment on:"The effect of prehospital critical care on survival following out of hospital cardiac arrest: A prospective observational study"
We read the article “The effect of pre-hospital critical care on survival following out of hospital cardiac arrest: A prospective observational study”1 with great interest. The authors should be complimented for their effort to answer the question whether or not pre-hospital critical care teams contribute to the survival of out-of-hospital cardiac arrest (OHCA) patients. In their study, they could not demonstrate a positive association between pre-hospital critical care and survival to hospital discharge, which was their primary endpoint. Although a couple of reasons for the lack of benefit from pre-hospital critical care for OHCA are provided, we think several important explanations remain unmentioned in the article
On O-X mode conversion in 2D inhomogeneous plasma with a sheared magnetic field
The conversion of an ordinary wave to an extraordinary wave in a 2D
inhomogeneous slab model of the plasma confined by a sheared magnetic field is
studied analytically.Comment: sub. to PPC
Scalable Spatial Super-Resolution using Entangled Photons
N00N states -- maximally path-entangled states of N photons -- exhibit
spatial interference patterns sharper than any classical interference pattern.
This is known as super-resolution. However, even with perfectly efficient
number-resolving detectors, the detection efficiency of all previously
demonstrated methods to measure such interference decreases exponentially with
the number of photons in the N00N state, often leading to the conclusion that
N00N states are unsuitable for spatial measurements. Here, we create spatial
super-resolution fringes with two-, three-, and four-photon N00N states, and
demonstrate a scalable implementation of the so-called ``optical centroid
measurement'' which provides an in-principle perfect detection efficiency.
Moreover, we compare the N00N-state interference to the corresponding classical
super-resolution interference. Although both provide the same increase in
spatial frequency, the visibility of the classical fringes decreases
exponentially with the number of detected photons, while the visibility of our
experimentally measured N00N-state super-resolution fringes remains
approximately constant with N. Our implementation of the optical centroid
measurement is a scalable method to measure high photon-number quantum
interference, an essential step forward for quantum-enhanced measurements,
overcoming what was believed to be a fundamental challenge to quantum
metrology
Helical, Angular and Radial Ordering in Narrow Capillaries
To enlighten the nature of the order-disorder and order-order transitions in
block copolymer melts confined in narrow capillaries we analyze peculiarities
of the conventional Landau weak crystallization theory of systems confined to
cylindrical geometry. This phenomenological approach provides a quantitative
classification of the cylindrical ordered morphologies by expansion of the
order parameter spatial distribution into the eigenfunctions of the Laplace
operator. The symmetry of the resulting ordered morphologies is shown to
strongly depend both on the boundary conditions (wall preference) and the ratio
of the cylinder radius and the wave length of the critical order parameter
fluctuations, which determine the bulk ordering of the system under
consideration. In particular, occurrence of the helical morphologies is a
rather general consequence of the imposed cylindrical symmetry for narrow
enough capillaries. We discuss also the ODT and OOT involving some other
simplest morphologies. The presented results are relevant also to other
ordering systems as charge-density waves appearing under addition of an ionic
solute to a solvent in its critical region, weakly charged polyelectrolyte
solutions in poor solvent, microemulsions etc.Comment: 6 pages, 3 figure
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