Feasibility study of an Integrated Program for Aerospace vehicle Design (IPAD). Volume 3: Support of the design process

The user requirements for computer support of the IPAD design process are identified. The user-system interface, language, equipment, and computational requirements are considered

Relativistic ideal Fermi gas at zero temperature and preferred frame

We discuss the limit T->0 of the relativistic ideal Fermi gas of luxons (particles moving with the speed of light) and tachyons (hypothetical particles faster than light) based on observations of our recent paper: K. Kowalski, J. Rembielinski and K.A. Smolinski, Phys. Rev. D, 76, 045018 (2007). For bradyons this limit is in fact the nonrelativistic one and therefore it is not studied herein

Asthma - is survival good enough?

Advances in asthma management, particularly the introduction of controller medication of which inhaled corticosteroids are the most important, has resulted in a steady decline in asthma mortality in most countries. This is usually accompanied by a decline in episodes of near-fatal asthma attacks and hospitalisations, and a reduction in other indicators of asthma morbidity. These gains have led to a shift in thinking on the management of asthma, away from simply preventing death and hospitalisations, toward achieving and maintaining sustained control of all clinical features

Gravitational Radiation from Preheating with Many Fields

Parametric resonances provide a mechanism by which particles can be created just after inflation. Thus far, attention has focused on a single or many inflaton fields coupled to a single scalar field. However, generically we expect the inflaton to couple to many other relativistic degrees of freedom present in the early universe. Using simulations in an expanding Friedmann-Lema\^itre-Robertson-Walker spacetime, in this paper we show how preheating is affected by the addition of multiple fields coupled to the inflaton. We focus our attention on gravitational wave production--an important potential observational signature of the preheating stage. We find that preheating and its gravitational wave signature is robust to the coupling of the inflaton to more matter fields.Comment: 7 pages, 8 figures, v2 submission version, thank you for comments

Generalized r-Modes of the Maclaurin Spheroids

Analytical solutions are presented for a class of generalized r-modes of rigidly rotating uniform density stars---the Maclaurin spheroids---with arbitrary values of the angular velocity. Our analysis is based on the work of Bryan; however, we derive the solutions using slightly different coordinates that give purely real representations of the r-modes. The class of generalized r-modes is much larger than the previously studied `classical' r-modes. In particular, for each l and m we find l-m (or l-1 for the m=0 case) distinct r-modes. Many of these previously unstudied r-modes (about 30% of those examined) are subject to a secular instability driven by gravitational radiation. The eigenfunctions of the `classical' r-modes, the l=m+1 case here, are found to have particularly simple analytical representations. These r-modes provide an interesting mathematical example of solutions to a hyperbolic eigenvalue problem.Comment: 12 pages, 3 figures; minor changes and additions as will appear in the version to be published in Physical Review D, January 199

The future of AD clinical trials with the advent of anti-amyloid therapies: An CTAD Task Force report

BACKGROUND: Aducanumab (ADUHELMTM) was approved for the treatment of Alzheimer\u27s disease (AD) in the US. This approval was supported by an effect on the cerebral amyloid plaque load and evidence of cognitive efficacy to be confirmed in post-marketing trials. Other anti-amyloid antibodies are under investigation in phase III (donanemab, lecanemab, gantenerumab) and have shown preliminary evidence of a cognitive benefit in phase II trials. Although these agents target a small segment of patients with mild cognitive impairment due to AD or mild AD dementia, their advent will change the design of future clinical trials both for anti-amyloid and non-amyloid drugs. These changes will promote the selection of patients in clinical trials by amyloid and tau biomarkers that identify patients with appropriate biology and may follow the treatment response to approved amyloid antibodies. The use of these agents creates the opportunity to test combined drug therapies and to conduct comparative assessments with innovative therapies and newly approved drugs available in clinical practice. Blood-based AD biomarkers should be implemented in research and could facilitate the recruitment into clinical trials. Anti-amyloid antibodies will have positive (e.g., more early diagnosis) and negative impacts (some subjects will be reluctant to participate in trials and risk assignment to placebo) on AD trials in the immediate future. We present the results of the CTAD Task Force on this topic, in Boston, November 6, 2021

Laplace transform of spherical Bessel functions

We provide a simple analytic formula in terms of elementary functions for the Laplace transform j_{l}(p) of the spherical Bessel function than that appearing in the literature, and we show that any such integral transform is a polynomial of order l in the variable p with constant coefficients for the first l-1 powers, and with an inverse tangent function of argument 1/p as the coefficient of the power l. We apply this formula for the Laplace transform of the memory function related to the Langevin equation in a one-dimensional Debye model.Comment: 5 pages LATEX, no figures. Accepted 2002, Physica Script

Relativistic and Radiative Corrections to the Mollow Spectrum

The incoherent, inelastic part of the resonance fluorescence spectrum of a laser-driven atom is known as the Mollow spectrum [B. R. Mollow, Phys. Rev. 188, 1969 (1969)]. Starting from this level of description, we discuss theoretical foundations of high-precision spectroscopy using the resonance fluorescence light of strongly laser-driven atoms. Specifically, we evaluate the leading relativistic and radiative corrections to the Mollow spectrum, up to the relative orders of (Z alpha)^2 and alpha(Z alpha)^2, respectively, and Bloch-Siegert shifts as well as stimulated radiative corrections involving off-resonant virtual states. Complete results are provided for the hydrogen 1S-2P_{1/2} and 1S-2P_{3/2} transitions; these include all relevant correction terms up to the specified order of approximation and could directly be compared to experimental data. As an application, the outcome of such experiments would allow for a sensitive test of the validity of the dressed-state basis as the natural description of the combined atom-laser system.Comment: 20 pages, 1 figure; RevTe

Global Electric Circuit Diurnal Variation Derived from Storm Overflight and Satellite Optical Lightning Datasets

We have combined analyses of over 1000 high altitude aircraft observations of electrified clouds with diurnal lightning statistics from the Lightning Imaging Sensor (LIS) and Optical Transient Detector (OTD) to produce an estimate of the diurnal variation in the global electric circuit. Using basic assumptions about the mean storm currents as a function of flash rate and location, and the global electric circuit, our estimate of the current in the global electric circuit matches the Carnegie curve diurnal variation to within 4% for all but two short periods of time. The agreement with the Carnegie curve was obtained without any tuning or adjustment of the satellite or aircraft data. Mean contributions to the global electric circuit from land and ocean thunderstorms are 1.1 kA (land) and 0.7 kA (ocean). Contributions to the global electric circuit from ESCs are 0.22 kA for ocean storms and 0.04 kA for land storms. Using our analysis, the mean total conduction current for the global electric circuit is 2.0 kA