New Technologies’ Promise to the Self and the Becoming of the Sacred: Insights from Georges Bataille’s Concept of Transgression

This article draws on Georges Bataille’s concept of transgression, a key element in Bataille’s theory of the sacred, to highlight structural implications of the way the self-empowerment ethos of new technologies suffuses the digital tracking culture. Pointing to the original conceptual stance of transgression, worked out against prohibition, I first argue that, beyond a critique of new technologies’ promise of self-empowerment as coming at the expense of an acknowledgement of the ultimate taboo—death—is the problem of the sanitizing of the tension between the crossing of the line of the symbolic taboo and prohibition; this undermines a “libidinal investment” towards the sacred, which is central in Bataille’s theory. Second, focussing on “eroticism”, since this embodies the emancipative potential of the Bataillean sacred, I argue that while a fear of eroticism marks out the digital technological realm, this is covered up by the blurring of boundaries between pleasure, fun and sex(iness) that currently governs our experience with technological devices

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adults. Although there are drugs effective on Ascaris, notably the benzimidazoles, those same drugs show poor efficacy particularly against whipworm (Trichuris trichiura) and to a certain extent hookworm. Parasitic nematodes also infect farm livestock and companion animals. Resistance to currently deployed human and veterinary anthelmintic drugs is a growing problem. Therefore, new chemical anthelmintic lead compounds are urgently needed. One of the fastest routes to a novel therapeutic lead is to screen libraries of drugs which are either already approved for human use or have already been part of clinical trials. We have pursued this approach to anthelmintic lead discovery using an invertebrate automated phenotyping platform (INVAPP) for screening chemicals and the well-established nematode genetic model organism Caenorhabditis elegans. The 400 compound Medicines for Malaria Venture (MMV) Pandemic Response Box library was screened with each compound tested initially at 1.0x10-4 M. We identified 6 compounds (MMV1593515 (vorapaxar), MMV102270 (diphyllin), MMV1581032 (ABX464), MMV1580796 (rubitecan), MMV1580505 and MMV1593531) active in both an L1-L4 growth/motility assay and in an L4 motility assay. For vorapaxar, an EC50 of 5.7x10-7 M was observed, a value comparable to those of some commercial anthelmintics. Although not a parasite, the ease with which high-throughput screens can be pursued on the free-living nematode C. elegans makes this a useful approach to identify chemical leads and complements the often lower-throughput experiments on parasitic nematode models

The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia.

Two case-control studies were set up to investigate the relationship between melanocytic naevi and risk of melanoma and to compare the naevus phenotype in two countries exposed to greatly different levels of sun exposure and different melanoma rates. In England 117 melanoma cases and 163 controls were recruited from the North-East Thames Region and 183 melanoma cases and 162 controls from New South Wales, Australia. Each subject underwent a whole-body naevus count performed by the same examiner in each country. Relative risks associated with melanocytic naevi in each country were calculated with comparison of naevus data in controls between Australia and England. Atypical naevi were strong risk factors for melanoma in both countries: the odds ratio (OR) for three or more atypical naevi was 4.6 (95% CI 2.0-10.7) in Australia compared with 51.7 (95% CI 6.5-408.4) in England. Common naevi were also significant risk factors in Australia and England with similar odds ratios in the two countries. Prevalence of atypical naevi was greater in Australian controls than in English controls: OR 9.7 (95% CI 1.2-81.7) for three or more atypical naevi in Australia compared with England. For young age groups, the median number of common naevi was greater in Australia than in the UK, whereas for older individuals this difference in naevi number between the two countries disappeared. The prevalence of naevi on non-sun-exposed sites in controls was not significantly different between the two countries. The atypical mole syndrome (AMS) phenotype was more prevalent in Australian controls (6%) than in English controls (2%). The results of this study support the role of sun exposure in the induction of atypical naevi in adults. There was a trend towards stronger risk factors associated with atypical naevi in England compared with Australia. The atypical mole syndrome, usually associated with a genetic susceptibility to melanoma, was more common in Australia than in England, suggesting genetic environmental interactions with the possibility of phenocopies induced by sunlight

Moho Depth of Northern Baja California, Mexico, From Teleseismic Receiver Functions

We estimated Moho depths from data recorded by permanent and temporary broadband seismic stations deployed in northern Baja California, Mexico, using the receiver function technique. This region is composed of two subregions of contrasting geological and topographical characteristics: The Peninsular Ranges of Baja California (PRBC), a batholith with high elevations (up to 2600 m); and the Mexicali Valley (MV) region, a sedimentary environment close to sea level. Crustal thickness derived from the P‐to‐S converted phases at 29 seismic stations were analyzed in 3 profiles: two that cross the two subregions, in ∼W‐E direction, and the third one that runs over the PRBC in a N‐S direction. For the PRBC, Moho depths vary from 35 to 45‐km, from 33ºN to 32ºN; and from 30 to 46‐km depth from 32ºN to 30.5ºN. From a profile that crosses the subregions in the W‐E direction; Moho depths vary from 45 to ∼34‐km under western and eastern PRBC, respectively; with an abrupt change of depth under the Main Gulf Escarpment (30º), from ∼32 to 30‐km; and depths of 17‐20‐km under the MV. Moho depths of the profile in an ∼W‐E direction at ∼31.5ºN from ∼30 to 40‐km, under topography that increase from 0 to 2600 m; and became shallower (16‐km depth) as the profile reaches the Gulf of California. These results show that deeper Moho is related to higher elevations with an abrupt change under the Main Gulf Escarpment, except for western PRBC were the Moho depth is not simply reflect isostatic compensation

A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45

The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45neg myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45neg Myeloma patients, particularly those with the most aggressive form, t(4,14)

Moho Depth of Northern Baja California, Mexico, From Teleseismic Receiver Functions

We estimated Moho depth from data recorded by permanent and temporary broadband seismic stations deployed in northern Baja California, Mexico using the receiver function technique. This region is composed, mainly, of two subregions of contrasting geological and topographical characteristics: The Peninsular Ranges of Baja California (PRBC), a batholith with high elevations (up to 2600 m above mean sea level); and the Mexicali Valley (MV) region, a sedimentary environment at around the mean sea level. Crustal thickness derived from the P-to-S converted phases at 29 seismic stations were analyzed in 3 profiles: two that cross the two subregions, in a ~W-E direction, and the third one that runs over the PRBC in a N-S direction. For the PRBC region, Moho depths vary from 35 to 45 km, from 33°;N to 32°;N; and from 30 to 46 km depth from 32°;N to 30.5°;N. From a profile that crosses the subregions in the W-E direction; Moho depths vary from 45 to ~34 km under the PRBC; with an abrupt change of depth under the Main Gulf Escarpment, from ~32 to 30 km; and depths of 17-20 km under the MV region. Moho depths of the profile that runs, of an almost W-E direction at ~31.5°; N, follow the eltimetry from 0 to 2600 m: from ~30 to 40 km; and became shallower (16 km depth) as the profile reaches the Gulf of California. These results show that deeper Moho is related to higher elevations with an abrupt change under the Main Gulf Escarpment