Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment

The process of corneal wound healing is complex and induces scar formation. Corneal scarring is a leading cause of blindness worldwide. The fibrotic healing of a major ocular wound disrupts the highly organized fibrillar collagen arrangement of the corneal stroma, rendering it opaque. The process of regaining this organized extracellular matrix (ECM) arrangement of the stromal layer to restore corneal transparency is complicated. The surface retention capacity of ocular drugs is poor, and there is a large gap between suitable corneal donors and clinical requirements. Therefore, a more efficient way of treating corneal scarring is needed. The eight major classes of interventions targeted as therapeutic tools for healing scarred corneas include those based on exosomes, targeted gene therapy, microRNAs, recombinant viral vectors, histone deacetylase inhibitors, bioactive molecules, growth factors, and nanotechnology. This review highlights the recent advancements in molecular therapeutics to restore a cornea without scarring. It also provides a scope to overcome the limitations of present studies and perform robust clinical research using these strategies. © 2022 by the authors

Evolution of collective and noncollective structures in Xe-123

An experiment involving a heavy-ion-induced fusion-evaporation reaction was carried out where high-spin states of 123Xe were populated in the 80Se (48Ca,5n) 123Xe reaction at 207 MeV beam energy. Gamma-ray coincidence events were recorded with the Gammasphere Ge detector array. The previously known level scheme was confirmed and enhanced with the addition of five new band structures and several interband transitions. Cranked Nilsson-Strutinsky (CNS) calculations were performed and compared with the experimental results in order to assign configurations to the bands.Additional co-authors: T Lauritsen, S Zhu, A Korichi, P Fallon, B M Nyakó, and J Timá

Highly deformed band structures due to core excitations in 123Xe

High-spin states in 123 Xe were populated in the 80 Se(48 Ca, 5n) 123 Xe reaction at a beam energy of 207 MeV. Gamma-ray coincidence events were recorded with the Gammasphere spectrometer. Four new high-spin bands have been discovered in this nucleus.The bands are compared with those calculated within the framework of cranked Nilsson-Strutinsky and cranked Nilsson-Strutinsky-Bogoliubov models. It is concluded that the configurations of the bands involve two-proton excita-tions across the Z = 50 as well as excitation of neutrons across the N = 82 shell gaps resulting in a large deformation, ε2 ∼ 0.30 and γ ∼ 5 • .Additional co-authors: F. G. Kondev, T. Lauritsen, S. Zhu, A. Korichi, P. Fallon, B. M. Nyakó, and J. Timá

Lifetime measurement in 122^{122}Ba and 122^{122}Cs using Doppler Shift Attenuation Method (DSAM)

International audienceThe nuclear structure exhibits transitional behaviour in the A'125 mass region as the nuclei lie between the spherical (Sn, Z=50) and deformed (Ce, Z=58) structures. Here exists a unique parity intruder subshell, h11/2, which can be accessed by both the protons and the neutrons. These h11/2 nucleons have opposite deformation driving effects which lead to an interplay of prolate, oblate or triaxial nuclear shapes[1]

Evolution of collective and noncollective structures in 123Xe^{123}\mathrm{Xe}

International audienceAn experiment involving a heavy-ion-induced fusion-evaporation reaction was carried out where high-spin states of Xe123 were populated in the Se80(Ca48,5n)Xe123 reaction at 207 MeV beam energy. Gamma-ray coincidence events were recorded with the Gammasphere Ge detector array. The previously known level scheme was confirmed and enhanced with the addition of five new band structures and several interband transitions. Cranked Nilsson-Strutinsky (CNS) calculations were performed and compared with the experimental results in order to assign configurations to the bands

Highly deformed band structures due to core excitations in 123^{123}Xe

International audienceHigh-spin states in Xe123 were populated in the Se80(Ca48, 5n)Xe123 reaction at a beam energy of 207 MeV. γ-ray coincidence events were recorded with the Gammasphere spectrometer. Four new high-spin bands have been discovered in this nucleus. The bands are compared with those calculated within the framework of cranked Nilsson-Strutinsky and cranked Nilsson-Strutinsky-Bogoliubov models. It is concluded that the configurations of the bands involve two-proton excitations across the Z=50 as well as excitation of neutrons across the N=82 shell gaps resulting in a large deformation, ɛ2≈0.30 and γ≈5∘

Search for collective and non-collective band structures in 123^{123}Xe

International audienceThe nuclei in the mass region A ≃125 lie between the spherical Sn nuclei(Z=50) and strongly deformed Ce nuclei(Z=58) and are therefore, transitional with respect to their shapes at low and high angular momenta. In this mass region, there exists a unique parity intruder orbital h11/2 which is accessible to both the protons and neutrons. These h11/2 nucleons have opposite deformation driving effects; neutrons drive the nucleus towards the oblate shape whereas the protons favour the prolate shape. Thus, the outcome of this interplay makes this region very interesting to study shape evolutions from lower to higher spins as the nucleus can have a prolate, an oblate or a triaxial shape depending on the alignment of the h11/2 nucleons[1]

Search for collective and non-collective band structures in 123^{123}Xe

International audienc