A Thirteenth-Century English Charter at Brock University

In the fall of 2008, staff of the Special Collections and Archives of the James A. Gibson library at Brock University in St. Catharines, Ontario, discovered a small, tightly folded, and clearly very old parchment document in a bag in the bottom drawer of a filing cabinet. The document, which had been transferred to the Library from the President’s Office in 1976, was stored without being catalogued, probably because it fell outside the scope of the department’s collection policy. It remained unexamined for over thirty years until early in 2009, when the announcement of its ‘rediscovery’ caused considerable excitement among the Brock University and Niagara communities. Efforts to trace the provenance of the Charter prior to its arrival at Brock University have proven unsuccessful. The document, dated to the mid-thirteenth century, records a grant of land in the village of Clopton in Warwickshire (see further below) by Robert de Clopton to his son William; although some of the individuals and places named in it are known from contemporaneous records, it does not appear to be referred to in secondary sources pertaining to the family, the estate, or the county and, in fact, seems to be completely unknown. The Clopton charter now has the distinction of being the oldest item in the holdings of the James A. Gibson Library at Brock University. This paper offers a description, transcription, translation and preliminary analysis of the document

The effect of data sources on the measurement of open access : a comparison of Dimensions and the Web of Science

With the growing number of open access (OA) mandates, the accurate measurement of OA publishing is an important policy issue. Existing studies have provided estimates of the prevalence of OA publications ranging from 27.9% to 53.7%, depending on the data source and period of investigation. This paper aims at providing a comparison of the proportion of OA publishing as represented in two major bibliometric databases, Web of Science (WoS) and Dimensions, and assesses how the choice of database affects the measurement of OA across different countries. Results show that a higher proportion of publications indexed in Dimensions are OA than those indexed by WoS, and that this is particularly true for publications originating from outside North America and Europe. The paper concludes with a discussion of the cause and consequences of these differences, motivating the use of more inclusive databases when examining OA, especially for publications originating beyond North America and Europe

Saccharomyces boulardii Improves Intestinal Cell Restitution through Activation of the α2β1 Integrin Collagen Receptor

Intestinal epithelial cell damage is frequently seen in the mucosal lesions of inflammatory bowel diseases such as ulcerative colitis or Crohn's disease. Complete remission of these diseases requires both the cessation of inflammation and the migration of enterocytes to repair the damaged epithelium. Lyophilized Saccharomyces boulardii (Sb, Biocodex) is a nonpathogenic yeast widely used as a therapeutic agent for the treatment and prevention of diarrhea and other gastrointestinal disorders. In this study, we determined whether Sb could accelerate enterocyte migration. Cell migration was determined in Sb force-fed C57BL6J mice and in an in vitro wound model. The impact on α2β1 integrin activity was assessed using adhesion assays and the analysis of α2β1 mediated signaling pathways both in vitro and in vivo. We demonstrated that Sb secretes compounds that enhance the migration of enterocytes independently of cell proliferation. This enhanced migration was associated with the ability of Sb to favor cell-extracellular matrix interaction. Indeed, the yeast activates α2β1 integrin collagen receptors. This leads to an increase in tyrosine phosphorylation of cytoplasmic molecules, including focal adhesion kinase and paxillin, involved in the integrin signaling pathway. These changes are associated with the reorganization of focal adhesion structures. In conclusion Sb secretes motogenic factors that enhance cell restitution through the dynamic regulation of α2β1 integrin activity. This could be of major importance in the development of novel therapies targeting diseases characterized by severe mucosal injury, such as inflammatory and infectious bowel diseases

Enkele aspekte rakende die bio-beskikbaarheid van chemiese verbindings afkomstig van Suid-Afrikaanse vliegas

MSc (Bedryfsfisiologie), North-West University, Potchefstroom CampusThe bioavailability of chemical compounds found on South African coal fly ash particles collected from Kendal, Lethabo and Matimba power stations was examined. Physiological sodium chloride solution, hydrochloric acid and simulated surfactant were used as leaching solutions to simulate human/fly ash interaction. The toxic potential of the leachates was evaluated by means of a lethality test (Daphnia test). The Salmonella Ames Spot test was used to detect mutagenic activity. The presence of metal compounds in the leachates was established by means of the Metal indicator test. Of the leaching solutions used hydrochloric acid was found to be the most efficient followed by physiological sodium chloride solution and simulated surfactant. Fly ash collected from Kendal power station had the highest toxic potential whilst the toxic potential of fly ash from Lethabo and Matimba power stations was more or less on a par. None of the leachates showed any mutagenic potential. The highest concentrations of metal compounds were recorded in respect of the Kendal leachates. The in vitro tests conducted in this study disclose certain tendencies. The results, however, cannot be directly applied to human beings. As the chemical compounds on fly ash can leach when coming into contact with body fluids and thus spread throughout the body, a long term biological monitoring programme based on the present study, can be embarked upon to establish whether the exposure to fly ash of personnel working in coal power stations, poses a health hazard to them.Master

Enkele aspekte rakende die bio-beskikbaarheid van chemiese verbindings afkomstig van Suid-Afrikaanse vliegas

MSc (Bedryfsfisiologie), North-West University, Potchefstroom CampusThe bioavailability of chemical compounds found on South African coal fly ash particles collected from Kendal, Lethabo and Matimba power stations was examined. Physiological sodium chloride solution, hydrochloric acid and simulated surfactant were used as leaching solutions to simulate human/fly ash interaction. The toxic potential of the leachates was evaluated by means of a lethality test (Daphnia test). The Salmonella Ames Spot test was used to detect mutagenic activity. The presence of metal compounds in the leachates was established by means of the Metal indicator test. Of the leaching solutions used hydrochloric acid was found to be the most efficient followed by physiological sodium chloride solution and simulated surfactant. Fly ash collected from Kendal power station had the highest toxic potential whilst the toxic potential of fly ash from Lethabo and Matimba power stations was more or less on a par. None of the leachates showed any mutagenic potential. The highest concentrations of metal compounds were recorded in respect of the Kendal leachates. The in vitro tests conducted in this study disclose certain tendencies. The results, however, cannot be directly applied to human beings. As the chemical compounds on fly ash can leach when coming into contact with body fluids and thus spread throughout the body, a long term biological monitoring programme based on the present study, can be embarked upon to establish whether the exposure to fly ash of personnel working in coal power stations, poses a health hazard to them.Master

The right to be forgotten : a South African perspective

The purpose of this Mini-Dissertation is to determine whether or not a data subject in South Africa can rely on the Right to be Forgotten (RTBF) as is illustrated in the case of Google Spain SL & Google Inc. v Agencia Española de Protección de Datos (AEPD) & Mario Costeja González (Google SL).1 This involves, inter alia, a critical analysis of the European Law as well as the provisions of the Protection of Personal Information Act (POPI).2 The Mini-Dissertation is structured as follows: Chapter 1: Introduction: Introduction, purpose and overview of the Mini-Dissertation. Chapter 2: An Overview of the European Law: An analysis of the relevant legislation and case-law of the European Union as well as its application to the RTBF. Chapter 3: Google Spain SL & Google Inc. v Agencia Española de Protección de Datos (AEPD) & Mario Costeja González: A detailed analysis of Judgment in Google SL as well as commentary and criticism to the RTBF. Chapter 4: The Right to be Forgotten in South Africa: A detailed analysis of the law pertaining to the protection of personal information in South Africa and the applicability of the RTBF in South Africa. This entails an investigation of the provisions of POPI as well as South African commentary to the RTBF. Chapter 5: Conclusion and recommendations.Mini Dissertation (LLM)--University of Pretoria, 2015.Mercantile LawLLMUnrestricte

Funksie van die "exemplum" in Prudentius se Cathemerinon-Himnes

M.A.Please refer to full text to view abstrac

The open access coverage of OpenAlex, Scopus and web of science

Les revues Diamond en libre accès (OA) offrent un modèle d’édition gratuit pour les auteurs et les lecteurs, mais leur manque d’indexation dans les principales bases de données bibliographiques pose des défis dans l’adoption de ces revues. De plus, les caractéristiques du libre accès, comme le pays de publication ont souvent été utilisés pour soutenir l’argument que les revues en libre accès sont plus diversifiées et visant à servir une communauté locale, mais il y a actuellement un manque de preuves empiriques liées aux caractéristiques géographiques et linguistiques des revues en libre accès

CONCERTO POUR 4 BASSONS ; CONCERTO POUR 3 FLUTES / Michel CORRETTE ; P. HONGNE (1er basson) ; J.P. RAMPAL (1ère flûte)

BnF-Partenariats, Collection sonore - BelieveContient une table des matière