22 research outputs found
Fire Prevention on the Farm and Ranch \u3ci\u3eWhat every country homeowner needs to know about fire!\u3c/i\u3e
Farm and ranch families have always been concerned with fire. Long distances from fire departments result in longer emergency response times. The lack of adequate water for fire fighting is another common problem. These two factors combine to make fire on the farm or ranch extremely costly and potentially dangerous.
America’s rural residents are ¼ of the nation’s population living on 98 percent of the land. Rural residents must give fire prevention first priority in protecting their homes, families and businesses.
Fire prevention on the farm or ranch starts with YOU
Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation
Network analysis became a powerful tool in recent years. Heat shock is a
well-characterized model of cellular dynamics. S. cerevisiae is an appropriate
model organism, since both its protein-protein interaction network
(interactome) and stress response at the gene expression level have been well
characterized. However, the analysis of the reorganization of the yeast
interactome during stress has not been investigated yet. We calculated the
changes of the interaction-weights of the yeast interactome from the changes of
mRNA expression levels upon heat shock. The major finding of our study is that
heat shock induced a significant decrease in both the overlaps and connections
of yeast interactome modules. In agreement with this the weighted diameter of
the yeast interactome had a 4.9-fold increase in heat shock. Several key
proteins of the heat shock response became centers of heat shock-induced local
communities, as well as bridges providing a residual connection of modules
after heat shock. The observed changes resemble to a "stratus-cumulus" type
transition of the interactome structure, since the unstressed yeast interactome
had a globally connected organization, similar to that of stratus clouds,
whereas the heat shocked interactome had a multifocal organization, similar to
that of cumulus clouds. Our results showed that heat shock induces a partial
disintegration of the global organization of the yeast interactome. This change
may be rather general occurring in many types of stresses. Moreover, other
complex systems, such as single proteins, social networks and ecosystems may
also decrease their inter-modular links, thus develop more compact modules, and
display a partial disintegration of their global structure in the initial phase
of crisis. Thus, our work may provide a model of a general, system-level
adaptation mechanism to environmental changes.Comment: 24 pages, 6 figures, 2 tables, 70 references + 22 pages 8 figures, 4
tables and 8 references in the enclosed Supplemen
Following the genes: a framework for animal modeling of psychiatric disorders
The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity. Defining the underlying pathogenic mechanisms will require an experimental and theoretical framework to make the links from mutation to altered behavior in an animal or psychopathology in a human. Here, we discuss key elements of such a framework, including cell type-based phenotyping, developmental trajectories, linking circuit properties at micro and macro scales and definition of neurobiological phenotypes that are directly translatable to humans
Reveille IV - 17
Student Activities: Mascots: Reveille IVphotograph date: Unknownpostcar
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This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library