ATLS in Moldova

Royal Free Hospital, London, United Kingdom, Orthopedics and Traumatology Clinic ”Vitalie Bețișor” State University of Medicine and Pharmacy ”Nicolae Testemițanu”, Republic of Moldova, Al VIII-lea Congres Naţional de Ortopedie și Traumatologie cu participare internaţională 12-14 octombrie 2016Background: Moldova is a country in Europe that trying to improve the health system with what is available. The mortality rate was found to be extremely high after major road traffic accident and this is due to poor old Soviet medical system in the hospital. Aim: The aim of our work, was to introduce a safe world wide recognised system to all doctors who are involved in trauma and to make sure they all have a simple common language. Method: An application has been made two years ago to the American College of Surgeon in order to obtain license to introduce and teach Advanced trauma Life Support in Moldova. This application was approved 18 months later and the license has been given to ATORM. Results: The first 16 candidates will be going to UK to get taught ATLS and some of them will become international and national instructors for ATLS. The procedure will continue afterwards and further 16 candidates will be taught and the ball will role over. Discussion: It is crucial and very important to introduce such teaching method and try to achieve a better health care system in Moldova. According to WHO, the mortality rate after major trauma in Moldavian Hospital is almost 70% and it is the highest together with Russia in the world. Not only, but the system has to be supported by all level of society in order to achieve better health care and trauma system in Moldova. Conclusion: The introduction of ATLS in Moldova is happening, and the system will start to function as soon as possible and we will reduce the mortality rate of trauma patients in this country

Spontaneous spinal cord infarction secondary to embolism from an aortic aneurysm mimicking as cauda equina due to disc prolapse: a case report

Spinal “stroke” is an uncommon cause of paraplegia. Spinal cord infarction from unruptured aortic aneurysm is rare. When encountered it poses diagnostic challenge to the clinician due to its rarity, which may lead to incorrect or delayed diagnosis. We report a case of 62-year-old man presenting to casualty as caudaequina syndrome due to spinal cord infarction secondary to emboli from an infra renal abdominal aortic aneurysm. To the authors knowledge this is first case of its kind and has not been reported in literature. Patient had improvement in proximal motor function following repair of the aneurysm, although he remained doubly incontinent in six months follow up

Can the adverse complications of foot drop be prevented by endoprosthesis: design and development of a prototype device

Can the adverse complications of foot drop be prevented by an endoprosthesis: design and development of a prototype device Abstract Foot drop is a very old problem since Jacob from the bible was limping when he was wrestling with the angels. Foot drop occurs very often, and it is a very common condition in trauma, after surgery, and neurological diseases. The aim of this project is to identify an endo-prosthesis and test it bio-mechanically and bio- medically in order to resolve the problem. This endo-prosthesis must improve the quality of life for patients suffering from foot drop due to the injury to the common peroneal nerve. The device that must be created should be small and surgically will be attached to the muscle internally and work as if the muscles and nerve were intact. The device would be tested outside the human body. It is important to throw light on that the device should be made of a material that is accepted by the human body and should have a stiffness that is close to the weight of the foot to ensure a normal motion. The intent of this bio-mechanical device is to help patients suffering from foot drop to restore normal motion. An endo-prosthesis that is implanted in the foot might be the solution to foot drop disease. The endo-prosthesis has a major role to do the opposite movement and..

Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle

Glycogen is an energy storage depot for the mammalian species. This review focuses on recent developments that have identified the role of nuclear hormone receptor (NR) signaling and epigenomic control in the regulation of important genes that modulate glycogen metabolism. Specifically, new studies have revealed that the NR4A subgroup (of the NR superfamily) are strikingly sensitive to beta-adrenergic stimulation in skeletal muscle, and transgenic studies in mice have revealed the expression of these NRs affects endurance and glycogen levels in muscle. Furthermore, other studies have demonstrated that one of the NR coregulator class of enzymes that mediate chromatin remodeling, the histone methyltransferases (for example, protein arginine methyltransferase 4) regulates the expression of several genes involved in glycogen metabolism and glycogen storage diseases in skeletal muscle. Importantly, NRs and histone methyltransferases, have the potential to be pharmacologically exploited and may provide novel targets in the quest to treat disorders of glycogen storage. (C) 2013 IUBMB Life, 65(8): 657-664, 201