Negotiating requests for reimbursement for community engagement: challenges in developing an educational video for genomic biobanking research in South Africa

Genomic research and the biobanking capacity it requires are experiencing considerable growth on the continent of Africa. However genomic research and biobanking raise a range of legal, ethical, social, and cultural issues, including concerns about broad consent, confidentiality, community stigmatization, discrimination, indefinite storage, and long-term use. There is a need to establish governance frameworks that address these issues, and many international health research ethics and biobanking guidelines now recommend that the best way to do so is by involving potential research participants and key community stakeholders in the research development and the process of acquiring samples and data through active community engagement (CE). This article describes the experience and challenges in developing an educational tool as part of a CE initiative in South Africa and the commentaries reflect on how this process may be improved going forward

Risk factors and spatial distribution of Schistosoma mansoni infection among preschool-aged children in Blapleu, Biankouma district, Western Côte d'Ivoire

Schistosoma mansoni infection is common among school-age children (SAC) in western Cote d'Ivoire. Little is known on the infection rate of preschool-aged children (PSAC) due to epidemiological data deficiency and nonappropriate formulation of the drug. Thus, mass drug administration for schistosomiasis control mainly targets SAC. This study aims to identify the risk factors and spatial distribution of S. mansoni infection among PSAC in Blapleu, endemic foci of S. mansoni. We carried out a cross-sectional study in households with PSAC aged 1-6 years. A structured questionnaire was administered to mothers/guardians to obtain data on sociodemographics and water contact behaviour of children. Point-of-care circulating cathodic antigen (POC-CCA) immunodiagnostic test in urine and Kato-Katz (K-K) method with stool were used for S. mansoni infection diagnosis. Multiple logistic regression analysis was performed to determine the relationship between S. mansoni infection and sociodemographic data. Coordinates recorded by a Global Positioning System of households, water source points, and infected PSAC were used to map the spatial distribution of S. mansoni infection cases. This study was conducted with 350 PSAC aged 1-6 years. The overall infection prevalence of S. mansoni varies from 31.43% with the K-K method to 62.86% with the POC-CCA. PSAC aged 2-6 years were highly infected with S. mansoni than those aged 1-2 years (OR = 14.24, 95% CI: 5.85-34.64). PSAC who did not have access and who do not live close to the infected water source were at a significant lower risk of S. mansoni infection (OR = 0.13, 95% CI: 0.057-0.30). The main purpose of water contact of PSAC was to help their mother for laundry that occurs weekly. In Blapleu, a high risk of S. mansoni infection was observed among PSAC. Schistosomiasis control effort in such localities should include information, education, and communication, water, sanitation, and hygiene, and particularly chemotherapy targeting PSAC, reinforcing the need of the paediatric praziquantel formulation

Cataclysmic Variables and Other Compact Binaries in the Globular Cluster NGC 362: Candidates from Chandra and HST

Highly sensitive and precise X-ray imaging from Chandra, combined with the superb spatial resolution of HST optical images, dramatically enhances our empirical understanding of compact binaries such as cataclysmic variables and low mass X-ray binaries, their progeny, and other stellar X-ray source populations deep into the cores of globular clusters. Our Chandra X-ray images of the globular cluster NGC 362 reveal 100 X-ray sources, the bulk of which are likely cluster members. Using HST color-magnitude and color-color diagrams, we quantitatively consider the optical content of the NGC 362 Chandra X-ray error circles, especially to assess and identify the compact binary population in this condensed-core globular cluster. Despite residual significant crowding in both X-rays and optical, we identify an excess population of H{\alpha}-emitting objects that is statistically associated with the Chandra X-ray sources. The X-ray and optical characteristics suggest that these are mainly cataclysmic variables, but we also identify a candidate quiescent low mass X-ray binary. A potentially interesting and largely unanticipated use of observations such as these may be to help constrain the macroscopic dynamic state of globular clusters.Comment: 6 pages, 6 figures, to appear in the proceedings of the conference "Binary Star Evolution: Mass Loss, Accretion, and Mergers," Mykonos, Greece, June 22-25, 201

Measuring the cosmic ray acceleration efficiency of a supernova remnant

Cosmic rays are the most energetic particles arriving at earth. Although most of them are thought to be accelerated by supernova remnants, the details of the acceleration process and its efficiency are not well determined. Here we show that the pressure induced by cosmic rays exceeds the thermal pressure behind the northeast shock of the supernova remnant RCW 86, where the X-ray emission is dominated by synchrotron radiation from ultra-relativistic electrons. We determined the cosmic-ray content from the thermal Doppler broadening measured with optical spectroscopy, combined with a proper-motion study in X- rays. The measured post-shock proton temperature in combination with the shock velocity does not agree with standard shock heating, implying that >50% of the post-shock pressure is produced by cosmic rays.Comment: Published in Science express, 10 pages, 5 figures and 2 table

X-ray and Optical Study of Low Core Density Globular Clusters NGC6144 and E3

We report on the Chandra X-ray Observatory and Hubble Space Telescope observation of two low core density globular clusters, NGC6144 and E3. By comparing the number of X-ray sources inside the half-mass radius to those outside, we found 6 X-ray sources within the half-mass radius of NGC6144, among which 4 are expected to be background sources; 3 X-ray sources are also found within the half-mass radius of E3, of which 3 is expected to be background source. Therefore, we cannot exclude that all our sources are background sources. However, combining the results from X-ray and optical observations, we found that 1-2 sources in NGC6144 and 1 source in E3 are likely to be cataclysmic variables and that 1 source in NGC6144 is an active binary, based on the X-ray and optical properties. The number of faint X-ray sources in NGC6144 and E3 found with Chandra and HST is higher than a prediction based on collision frequency, but is closer to that based on mass. Our observations strongly suggest that the compact binary systems in NGC6144 and E3 are primordial in origin.Comment: 28 pages, 9 figures, 6 tables, Accepted for publication in Ap

Prevalence of Schistosoma mono- and co-infections with multiple common parasites and associated risk factors and morbidity profile among adults in the Taabo health and demographic surveillance system, South-Central Côte d'Ivoire

BACKGROUND: Schistosomiasis remains an important public health problem, also among adults, and infected individuals not treated serve as a reservoir for continued transmission. Despite this fact, evidence on the epidemiology of schistosomiasis in adults in Cote d'Ivoire is scanty. This study aimed to determine the prevalence and risk factors of Schistosoma infection and co-infection with other helminth species and Plasmodium among adults in the Taabo region in the south-central part of Cote d'Ivoire. METHODS: A cross-sectional survey was carried out in April and May 2017 in the frame of the "Cote d'Ivoire Dual Burden of Disease Study" (CoDuBu). A total of 901 randomly selected individuals, aged 18-90 years, provided blood, stool and urine samples for the diagnosis of malaria and helminth infections. Stool samples were subjected to the Kato-Katz technique for detection of Schistosoma mansoni and soil-transmitted helminth eggs, while urine samples were examined for eggs of Schistosoma haematobium and circulating cathodic antigen of S. mansoni. Risk factors and morbidity profiles were assessed using health examination and questionnaires. Multinomial logistic regressions were employed to identify risk factors and morbidity patterns associated with S. mansoni mono- and co-infections. RESULTS: The prevalence of S. mansoni and S. haematobium was 23.2% and 1.0%, respectively. Most S. mansoni were mono-infections (81.3%). Independent determinants of S. mansoni infection were young age, low socioeconomic status (mono- and co-infection) and poor hygiene practices (co-infection) (P < 0.05). S. mansoni infection was independently associated with higher pain and symptom scores (mono-infection), poor self-rated health and low healthcare use (co-infection) (P < 0.05). CONCLUSIONS: This study showed that adults represent a substantial reservoir of S. mansoni. To sustain schistosomiasis control and improve people's wellbeing, it is important to expand preventive chemotherapy from school-aged children to adults, coupled with hygiene and health education

Gravitational wave astronomy with the SKA

On a time scale of years to decades, gravitational wave (GW) astronomy will become a reality. Low frequency (nanoHz) GWs are detectable through long-term timing observations of the most stable pulsars. Radio observatories worldwide are currently carrying out observing programmes to detect GWs, with data sets being shared through the International Pulsar Timing Array project. One of the most likely sources of low frequency GWs are supermassive black hole binaries (SMBHBs), detectable as a background due to a large number of binaries, or as continuous or burst emission from individual sources. No GW signal has yet been detected, but stringent constraints are already being placed on galaxy evolution models. The SKA will bring this research to fruition. In this chapter, we describe how timing observations using SKA1 will contribute to detecting GWs, or can confirm a detection if a first signal already has been identified when SKA1 commences observations. We describe how SKA observations will identify the source(s) of a GW signal, search for anisotropies in the background, improve models of galaxy evolution, test theories of gravity, and characterise the early inspiral phase of a SMBHB system. We describe the impact of the large number of millisecond pulsars to be discovered by the SKA; and the observing cadence, observation durations, and instrumentation required to reach the necessary sensitivity. We describe the noise processes that will influence the achievable precision with the SKA. We assume a long-term timing programme using the SKA1-MID array and consider the implications of modifications to the current design. We describe the possible benefits from observations using SKA1-LOW. Finally, we describe GW detection prospects with SKA1 and SKA2, and end with a description of the expectations of GW astronomy.Comment: 19 pages, 3 figures, to be published in: "Advancing Astrophysics with the Square Kilometre Array", Proceedings of Science, PoS(AASKA14)03

LOFAR discovery of the fastest-spinning millisecond pulsar in the Galactic field

We report the discovery of PSR J0952$-$0607, a 707-Hz binary millisecond pulsar which is now the fastest-spinning neutron star known in the Galactic field (i.e., outside of a globular cluster). PSR J0952$-$0607 was found using LOFAR at a central observing frequency of 135 MHz, well below the 300 MHz to 3 GHz frequencies typically used in pulsar searches. The discovery is part of an ongoing LOFAR survey targeting unassociated Fermi Large Area Telescope $\gamma$-ray sources. PSR J0952$-$0607 is in a 6.42-hr orbit around a very low-mass companion ($M_\mathrm{c}\gtrsim0.02$ M$_\odot$) and we identify a strongly variable optical source, modulated at the orbital period of the pulsar, as the binary companion. The light curve of the companion varies by 1.6 mag from $r^\prime=22.2$ at maximum to $r^\prime>23.8$, indicating that it is irradiated by the pulsar wind. Swift observations place a 3-$\sigma$ upper limit on the $0.3-10$ keV X-ray luminosity of $L_X < 1.1 \times 10^{31}$ erg s$^{-1}$ (using the 0.97 kpc distance inferred from the dispersion measure). Though no eclipses of the radio pulsar are observed, the properties of the system classify it as a black widow binary. The radio pulsed spectrum of PSR J0952$-$0607, as determined through flux density measurements at 150 and 350 MHz, is extremely steep with $\alpha\sim-3$ (where $S \propto \nu^{\alpha}$). We discuss the growing evidence that the fastest-spinning radio pulsars have exceptionally steep radio spectra, as well as the prospects for finding more sources like PSR J0952$-$0607.Comment: 9 pages, 3 figures, 1 table, published in ApJ letter