202 research outputs found
Negotiating requests for reimbursement for community engagement: challenges in developing an educational video for genomic biobanking research in South Africa
Genomic research and the biobanking capacity it requires are experiencing considerable growth on the continent of Africa. However genomic research and biobanking raise a range of legal, ethical, social, and cultural issues, including concerns about broad consent, confidentiality, community stigmatization, discrimination, indefinite storage, and long-term use. There is a need to establish governance frameworks that address these issues, and many international health research ethics and biobanking guidelines now recommend that the best way to do so is by involving potential research participants and key community stakeholders in the research development and the process of acquiring samples and data through active community engagement (CE). This article describes the experience and challenges in developing an educational tool as part of a CE initiative in South Africa and the commentaries reflect on how this process may be improved going forward
Risk factors and spatial distribution of Schistosoma mansoni infection among preschool-aged children in Blapleu, Biankouma district, Western Côte d'Ivoire
Schistosoma mansoni infection is common among school-age children (SAC) in western Cote d'Ivoire. Little is known on the infection rate of preschool-aged children (PSAC) due to epidemiological data deficiency and nonappropriate formulation of the drug. Thus, mass drug administration for schistosomiasis control mainly targets SAC. This study aims to identify the risk factors and spatial distribution of S. mansoni infection among PSAC in Blapleu, endemic foci of S. mansoni. We carried out a cross-sectional study in households with PSAC aged 1-6 years. A structured questionnaire was administered to mothers/guardians to obtain data on sociodemographics and water contact behaviour of children. Point-of-care circulating cathodic antigen (POC-CCA) immunodiagnostic test in urine and Kato-Katz (K-K) method with stool were used for S. mansoni infection diagnosis. Multiple logistic regression analysis was performed to determine the relationship between S. mansoni infection and sociodemographic data. Coordinates recorded by a Global Positioning System of households, water source points, and infected PSAC were used to map the spatial distribution of S. mansoni infection cases. This study was conducted with 350 PSAC aged 1-6 years. The overall infection prevalence of S. mansoni varies from 31.43% with the K-K method to 62.86% with the POC-CCA. PSAC aged 2-6 years were highly infected with S. mansoni than those aged 1-2 years (OR = 14.24, 95% CI: 5.85-34.64). PSAC who did not have access and who do not live close to the infected water source were at a significant lower risk of S. mansoni infection (OR = 0.13, 95% CI: 0.057-0.30). The main purpose of water contact of PSAC was to help their mother for laundry that occurs weekly. In Blapleu, a high risk of S. mansoni infection was observed among PSAC. Schistosomiasis control effort in such localities should include information, education, and communication, water, sanitation, and hygiene, and particularly chemotherapy targeting PSAC, reinforcing the need of the paediatric praziquantel formulation
Cataclysmic Variables and Other Compact Binaries in the Globular Cluster NGC 362: Candidates from Chandra and HST
Highly sensitive and precise X-ray imaging from Chandra, combined with the
superb spatial resolution of HST optical images, dramatically enhances our
empirical understanding of compact binaries such as cataclysmic variables and
low mass X-ray binaries, their progeny, and other stellar X-ray source
populations deep into the cores of globular clusters. Our Chandra X-ray images
of the globular cluster NGC 362 reveal 100 X-ray sources, the bulk of which are
likely cluster members. Using HST color-magnitude and color-color diagrams, we
quantitatively consider the optical content of the NGC 362 Chandra X-ray error
circles, especially to assess and identify the compact binary population in
this condensed-core globular cluster. Despite residual significant crowding in
both X-rays and optical, we identify an excess population of H{\alpha}-emitting
objects that is statistically associated with the Chandra X-ray sources. The
X-ray and optical characteristics suggest that these are mainly cataclysmic
variables, but we also identify a candidate quiescent low mass X-ray binary. A
potentially interesting and largely unanticipated use of observations such as
these may be to help constrain the macroscopic dynamic state of globular
clusters.Comment: 6 pages, 6 figures, to appear in the proceedings of the conference
"Binary Star Evolution: Mass Loss, Accretion, and Mergers," Mykonos, Greece,
June 22-25, 201
Measuring the cosmic ray acceleration efficiency of a supernova remnant
Cosmic rays are the most energetic particles arriving at earth. Although most
of them are thought to be accelerated by supernova remnants, the details of the
acceleration process and its efficiency are not well determined. Here we show
that the pressure induced by cosmic rays exceeds the thermal pressure behind
the northeast shock of the supernova remnant RCW 86, where the X-ray emission
is dominated by synchrotron radiation from ultra-relativistic electrons. We
determined the cosmic-ray content from the thermal Doppler broadening measured
with optical spectroscopy, combined with a proper-motion study in X- rays. The
measured post-shock proton temperature in combination with the shock velocity
does not agree with standard shock heating, implying that >50% of the
post-shock pressure is produced by cosmic rays.Comment: Published in Science express, 10 pages, 5 figures and 2 table
X-ray and Optical Study of Low Core Density Globular Clusters NGC6144 and E3
We report on the Chandra X-ray Observatory and Hubble Space Telescope
observation of two low core density globular clusters, NGC6144 and E3. By
comparing the number of X-ray sources inside the half-mass radius to those
outside, we found 6 X-ray sources within the half-mass radius of NGC6144, among
which 4 are expected to be background sources; 3 X-ray sources are also found
within the half-mass radius of E3, of which 3 is expected to be background
source. Therefore, we cannot exclude that all our sources are background
sources. However, combining the results from X-ray and optical observations, we
found that 1-2 sources in NGC6144 and 1 source in E3 are likely to be
cataclysmic variables and that 1 source in NGC6144 is an active binary, based
on the X-ray and optical properties. The number of faint X-ray sources in
NGC6144 and E3 found with Chandra and HST is higher than a prediction based on
collision frequency, but is closer to that based on mass. Our observations
strongly suggest that the compact binary systems in NGC6144 and E3 are
primordial in origin.Comment: 28 pages, 9 figures, 6 tables, Accepted for publication in Ap
Prevalence of Schistosoma mono- and co-infections with multiple common parasites and associated risk factors and morbidity profile among adults in the Taabo health and demographic surveillance system, South-Central Côte d'Ivoire
BACKGROUND: Schistosomiasis remains an important public health problem, also among adults, and infected individuals not treated serve as a reservoir for continued transmission. Despite this fact, evidence on the epidemiology of schistosomiasis in adults in Cote d'Ivoire is scanty. This study aimed to determine the prevalence and risk factors of Schistosoma infection and co-infection with other helminth species and Plasmodium among adults in the Taabo region in the south-central part of Cote d'Ivoire. METHODS: A cross-sectional survey was carried out in April and May 2017 in the frame of the "Cote d'Ivoire Dual Burden of Disease Study" (CoDuBu). A total of 901 randomly selected individuals, aged 18-90 years, provided blood, stool and urine samples for the diagnosis of malaria and helminth infections. Stool samples were subjected to the Kato-Katz technique for detection of Schistosoma mansoni and soil-transmitted helminth eggs, while urine samples were examined for eggs of Schistosoma haematobium and circulating cathodic antigen of S. mansoni. Risk factors and morbidity profiles were assessed using health examination and questionnaires. Multinomial logistic regressions were employed to identify risk factors and morbidity patterns associated with S. mansoni mono- and co-infections. RESULTS: The prevalence of S. mansoni and S. haematobium was 23.2% and 1.0%, respectively. Most S. mansoni were mono-infections (81.3%). Independent determinants of S. mansoni infection were young age, low socioeconomic status (mono- and co-infection) and poor hygiene practices (co-infection) (P < 0.05). S. mansoni infection was independently associated with higher pain and symptom scores (mono-infection), poor self-rated health and low healthcare use (co-infection) (P < 0.05). CONCLUSIONS: This study showed that adults represent a substantial reservoir of S. mansoni. To sustain schistosomiasis control and improve people's wellbeing, it is important to expand preventive chemotherapy from school-aged children to adults, coupled with hygiene and health education
Gravitational wave astronomy with the SKA
On a time scale of years to decades, gravitational wave (GW) astronomy will
become a reality. Low frequency (nanoHz) GWs are detectable through long-term
timing observations of the most stable pulsars. Radio observatories worldwide
are currently carrying out observing programmes to detect GWs, with data sets
being shared through the International Pulsar Timing Array project. One of the
most likely sources of low frequency GWs are supermassive black hole binaries
(SMBHBs), detectable as a background due to a large number of binaries, or as
continuous or burst emission from individual sources. No GW signal has yet been
detected, but stringent constraints are already being placed on galaxy
evolution models. The SKA will bring this research to fruition.
In this chapter, we describe how timing observations using SKA1 will
contribute to detecting GWs, or can confirm a detection if a first signal
already has been identified when SKA1 commences observations. We describe how
SKA observations will identify the source(s) of a GW signal, search for
anisotropies in the background, improve models of galaxy evolution, test
theories of gravity, and characterise the early inspiral phase of a SMBHB
system.
We describe the impact of the large number of millisecond pulsars to be
discovered by the SKA; and the observing cadence, observation durations, and
instrumentation required to reach the necessary sensitivity. We describe the
noise processes that will influence the achievable precision with the SKA. We
assume a long-term timing programme using the SKA1-MID array and consider the
implications of modifications to the current design. We describe the possible
benefits from observations using SKA1-LOW. Finally, we describe GW detection
prospects with SKA1 and SKA2, and end with a description of the expectations of
GW astronomy.Comment: 19 pages, 3 figures, to be published in: "Advancing Astrophysics with
the Square Kilometre Array", Proceedings of Science, PoS(AASKA14)03
Baseline and impact of first-year intervention on Schistosoma haematobium infection in seasonal transmission foci in the northern and central parts of Côte d'Ivoire
LOFAR discovery of the fastest-spinning millisecond pulsar in the Galactic field
We report the discovery of PSR J09520607, a 707-Hz binary millisecond
pulsar which is now the fastest-spinning neutron star known in the Galactic
field (i.e., outside of a globular cluster). PSR J09520607 was found using
LOFAR at a central observing frequency of 135 MHz, well below the 300 MHz to 3
GHz frequencies typically used in pulsar searches. The discovery is part of an
ongoing LOFAR survey targeting unassociated Fermi Large Area Telescope
-ray sources. PSR J09520607 is in a 6.42-hr orbit around a very
low-mass companion ( M) and we identify a
strongly variable optical source, modulated at the orbital period of the
pulsar, as the binary companion. The light curve of the companion varies by 1.6
mag from at maximum to , indicating that it is
irradiated by the pulsar wind. Swift observations place a 3- upper
limit on the keV X-ray luminosity of erg
s (using the 0.97 kpc distance inferred from the dispersion measure).
Though no eclipses of the radio pulsar are observed, the properties of the
system classify it as a black widow binary. The radio pulsed spectrum of PSR
J09520607, as determined through flux density measurements at 150 and 350
MHz, is extremely steep with (where ).
We discuss the growing evidence that the fastest-spinning radio pulsars have
exceptionally steep radio spectra, as well as the prospects for finding more
sources like PSR J09520607.Comment: 9 pages, 3 figures, 1 table, published in ApJ letter
Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d'Ivoire
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