Change in blood glucose level in rats after immobilization

Experiments were carried out on male white rats divided into four groups. In group one the blood glucose level was determined immediately after immobilization. In the other three groups, two hours following immobilization, the blood glucose level was determined every 20 minutes for 3 hours 40 minutes by the glucose oxidase method. Preliminary immobilization for 2 hours removed the increase in the blood glucose caused by the stress reaction. By the 2nd hour of immobilization in the presence of continuing stress, the blood glucose level stabilized and varied within 42 + or - 5.5 and 47 + or - 8.1 mg %. Within 2 hours after the immobilization, the differences in the blood glucose level of the rats from the control groups were statistically insignificant

Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc

Studying of the Polylactide or Polyglycylidactide Surface Layer Biodegradation in Neutral Media for the Subsequent Layered Composite Creation

  The processes of biodegradation in phosphate buffer with pH 7.4 and 0.9 wt.% NaCl of polymer polylactide or polyglycylidactide films for the subsequent creation of a layered composite with a biodegradable layer on the basis of a nickel-free shape memory alloy TiNbTaZr were studied. The structure of the samples was determined by SEM and an optical microscope. For polylactide films the rate of biodegradation did not depend on the mass of the film. A gradual decrease in the rate of biodegradation at any mass with a similar dependence on time is noted. With an increase in the mass of films based on poly(glycolide-lactide) the rate of biodegradation increased. And even at the initial stage the dissolution rate is 2-3 times higher than in pure polylactide. On day 180, complete dissolution of the polyglycolidelactide was observed (even a precipitate was not observed) and completely entire polylactide films, however, lost  their transparency, was noted

SOCIAL PROJECT "PUSHKIN CARD": EFFICIENCY OF SUBSIDIES

В статье проведен микроэкономический анализ и сопоставление двух способов стимулирования экономики с помощью определенной суммы, выделяемой из государственного бюджета. Представлены результаты социологического опроса группы людей, подкрепляющего данные о статистике посещения культурных мест.The article carried out a microeconomic analysis and comparison of two ways to stimulate the economy with the help of a certain amount allocated from the state budget. The results of a sociological survey of a group of people are presented, reinforcing the data on the statistics of visiting cultural places

Use of polypeptide neuroprotection for prevention of postoperative cognitive dysfunction after cardiac surgery: a pilot prospective randomized placebo-controlled clinical study

Aim. The study was designed to evaluate the efficacy of polypeptide neuroprotection using brain protein “Cellex” for prevention of postoperative cognitive dysfunction after cardiac surgery.Methods. Our study included 60 patients undergoing elective cardiosurgical operations, who were randomized into two groups. In the “Cellex” group, the patients received 1.0 ml of “Cellex” subcutaneously daily during 8 days, beginning from the preoperative day, while the control group patients were given a saline placebo. The cognitive function was assessed using a Montreal cognitive assessment (MoCA) test on the day before surgery and also at Days 3 and 7 postoperatively. The plasma concentrations of S100b protein were measured before surgery, and at Days 3 and 7. The patients’ gas exchange, hemodynamics and cerebral oxygenation were monitored. In addition, the efficacy of “Cellex” and the severity of cognitive dysfunction were evaluated intraoperatively under cardiopulmonary bypass.Results. The duration of intervention and mechanical ventilation, as well as hemodynamics and cerebral oximetry data did not differ significantly between the groups. There was a transient decline of cognitive functions and an increase in plasma concentration of S100b at Day 3 after surgery in both groups (p&lt;0.05). At Day 7, the MoCA score was still decreased in the control group (p&lt;0.003), but returned to the baseline in the “Cellex” group. These effects became more pronounced after cardiopulmonary bypass. The intraoperative PaCO2 correlated with cerebral oxygenation surgery by the beginning and at the end of surgery (rho = 0.305, p = 0.033 and rho = 0.533; p&lt;0.001). Conclusion. The perioperative use of “Cellex” can attenuate cognitive dysfunction after cardiac surgery, especially when following interventions under cardiopulmonary bypass.Received 25 May 2017. Revised 9 November 2017. Accepted 13 November 2017.Funding: The study was carried out with support of the “Farm-Sintez” company’s grant. The money was spent for purchase of the preparation, the authors’ honoraria and purchase of a kit for determining S100b protein concentration. The sponsors’ support had no impact on the study design and data acquisition, analysis and interpretation. The “Farm-Sintez” company’s representatives were not participating in the preparation and publication of the article.Conflict of interest: The study was carried out with support of the “Farm-Sintez” company’s grant.Author contributionsConception and study design: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, M.Yu. Kirov Data collection and analysis: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, I.G. Baskakova, A.N. Kiriluk, D.N. Kazarinov, K.M. Checkaya, T.S. Isakova, M.A. Rumyanceva, V.Yu. Slastilin Statistical data analysis: M.M. Sokolova Drafting the article: M.A. Putanov, M.M. Sokolova Critical revision of the article: M.Yu. Kirov Final approval of the version to be published: M.A. Putanov, M.M. Sokolova, P.I. Lenkin, V.Yu. Slastilin, I.G. Baskakova, A.N. Kiriluk, D.N. Kazarinov, K.M. Checkaya, T.S. Isakova, M.A. Rumyanceva, M.Yu. Kirov</p

Reduced Graphene Oxide Aerogel inside Melamine Sponge as an Electrocatalyst for the Oxygen Reduction Reaction

A graphene oxide aerogel (GOA) was formed inside a melamine sponge (MS) framework. After reduction with hydrazine at 60 &deg;C, the electrical conductive nitrogen-enriched rGOA-MS composite material with a specific density of 20.1 mg/cm3 was used to fabricate an electrode, which proved to be a promising electrocatalyst for the oxygen reduction reaction. The rGOA-MS composite material was characterized by elemental analysis, scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. It was found that nitrogen in the material is presented by different types with the maximum concentration of pyrrole-like nitrogen. By using Raman scattering it was established that the rGOA component of the material is graphene-like carbon with an average size of the sp2-domains of 5.7 nm. This explains a quite high conductivity of the composite obtained