8 research outputs found
RICORS2040 : The need for collaborative research in chronic kidney disease
Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true
Otimização das condições de pré-redução do As(V) em extratos do método BCR para quantificação de arsênio por HG-AAS
The supergalactic plane revisited with the optical redshift survey
We re-examine the existence and extent of the planar structure in the local galaxy density field, the so-called supergalactic plane (SGP). This structure is studied here in three dimensions using both the new Optical Redshift Survey (ORS) and the IRAS 1.2-Jy redshift survey. The density contrast in a slab of thickness 20 h-ˡ Mpc and diameter 80 Mpc aligned with the standard de Vaucouleurs supergalactic coordinates is δsgp ~ 0.5 for both ORS and IRAS. The structure of the SGP is not well described by a homogeneous ellipsoid, although it does appear to be a flattened structure, which we quantify by calculating the moment of inertia tensor of the density field. The directions of the principal axes vary with radius, but the minor axis remains within ѳuz , 30º of the standard SGP Z-axis, out to a radius of 80 h-ˡ Mpc, for both ORS and IRAS. However, the structure changes shape with radius, varying between a flattened pancake and a dumbbell, the latter at a radius of ~50 h-ˡ Mpc, where the Great Attractor and Perseus-Pisces superclusters dominate the distribution. This calls to question the connectivity of the `plane' beyond ~ 40 h-ˡ Mpc. The configuration found here can be viewed as part of a web of filaments and sheets, rather than as an isolated pancake-like structure. An optimal minimum variance reconstruction of the density field using Wiener filtering, which corrects for both redshift distortion and shot noise, yields a similar misalignment angle and behaviour of axes. The background-independent statistic of axes proposed here can be best used for testing cosmological models by comparison with N-body simulations