Automatic Pill Reminder for Easy Supervision

In this paper we present a working model of an automatic pill reminder and dispenser setup that can alleviate irregularities in taking prescribed dosage of medicines at the right time dictated by the medical practitioner and switch from approaches predominantly dependent on human memory to automation with negligible supervision, thus relieving persons from error-prone tasks of giving wrong medicine at the wrong time in the wrong amount.Comment: 5 pages, 7 figures, ICISS- 2017 (IEEE Conference

Development and Design of Energy Efficient Oil-Flooded Screw Compressors

It is estimated that about 17% of the world's generated power is used for compression. Thus all, even minor improvement of the efficiency of compressors will substantially reduce CO2 emission. This paper presents development of family of energy efficient oil-flooded screw compressors for Kirloskar Pneumatic Company Ltd. The developmental techniques adopted to improve efficiency such as introduction of superior 'N' rotor profile, rotor clearance management, performance calculation using 3D CCM (Computational Continuum Mechanics), direct parametric interface to CAD (Computer Aided Design), which contains bearing selection for complete 3D solid modelling. Also, contemporary prototyping and experimental investigation is supported by the fully computerised data acquisition and processing. The cumulative improvement of all these elements of the design process resulted in a very efficient machine which guarantees the competitive position of Kirloskar Pneumatic Company Limited in the screw compressor market

Electronic Analog Computer Hydrologic Simulation of the Upper Bear River Basin

OF the total precipitation falling on watersheds throughout the world, an average of approximately 85 percent returns directly to the atmosphere through evaporation and use by mountain vegetation. The remaining 15 percent moves from the watersheds as runoff and becomes available in the valleys to be used by man for irrigation, industry, recreation, and many other requirements in recent years has led to an increasing need for efficient management of available water resources, and in this regard computer modeling or simulation has proved to be a powerful tool. The study described herein involves simulation of the hydrologic system of the upper Bear River Basin by means of an electronic analog computer. The various processes within the model are linked by the continuity of mass principles, which requires a hydrologic balance at all points. The analog computer is ideally suited to the soluation of the time-dependent differential equations of the model and to the trial and error process required during testing and verification. The primary objectives of the present study are: (i) to develop, using an analog computer, a simulation model of the hydrologic system of the upper Bear River Basin; and (ii) to demonstrate the applicability of the simulation model to water resource planning in the Bear River Basin by evaluating various alternative management possibilities subject to selected constraints. A brief review of computer modeling is included in Chapter II. The development of the hydrologic and the corresponding analog computer model of the upper Bear River Basin is detailed in Chapter III. Results of the study are included in Chapter IV. Conclusions and limitations are mentioned in Chapter V. Finally, brief summary and recommendations for additional studies are presented in the last chapter of this report

Arginine vasopressin-induced glucagon release: interaction with glucose and cyclic AMP-dependent protein kinase

The first study purpose was to investigate the glucose dependency of arginine vasopressin (AVP)-induced insulin, glucagon and somatostatin release from the perfused rat pancreas. AVP (30 or 300 pmol/L) was tested in the presence of glucose concentrations of 0, 1.4, 5.5 (basal level), or 20 mmol/L. The findings from this study suggested that AVP may increase insulin and glucagon release by a direct action on beta- and alpha-cells, respectively. These increases are glucose-dependent; the higher the glucose concentration, the greater the enhancement of AVP-induced insulin release. In contrast, the lower the glucose concentration, the greater the enhancement of AVP-induced glucagon release. AVP not only can enhance glucose-induced insulin release, but also can initiate insulin release. alpha-cells are much more sensitive to AVP than beta-cells in hormone release. Furthermore, our results confirmed the previous findings that hypoglycemia directly increases glucagon and decreases insulin release.;The second study purpose was to characterize the mechanisms by which cAMP/PKA enhances AVP-induced glucagon release and provide further details in the intracellular molecular components involved in this enhancement, particularly at the level of exocytosis. Increasing intracellular cAMP levels by forskolin or IBMX enhanced AVP-induced glucagon release from the perfused rat pancreas and the clonal alpha-cells InR1G9. cAMP/PKA did not increase [Ca 2+]i nor did it;enhance AVP-induced [Ca2+]i increase. Forskolin and IBMX enhanced AVP-induced glucagon release in Ca2+-containing but not in Ca2+-free medium. InR1G9 cells were loaded with styryl dye FM1-43 to measure the size of readily releasable pool (RRP). The combination of AVP and forskolin induced higher increase in fluorescence intensity than AVP or forskolin alone, which reflects an increase in the size of the RRP. Secretory granules in the reserve pool (RP) are thought to be reversibly connected to the actin-based cytoskeleton by synapsin I. Pretreatment with antisynapsin I antibody abolished the effect of forskolin/AVP-induced glucagon release. In addition, FM1-43 loading experiments showed that synapsin I is involved in recruitment of secretory granules from RP to RRP. Our results suggested that cAMP, acting through PKA, increases the number of secretory granules in the RRP by mobilization of granules from the RP, an action mediated by synapsin I

Historical and Projected Surface Temperature over India during the 20th and 21st century.

Surface Temperature (ST) over India has increased by ~0.055 K/decade during 1860-2005 and follows the global warming trend. Here, the natural and external forcings (e.g., natural and anthropogenic) responsible for ST variability are studied from Coupled Model Inter-comparison phase 5 (CMIP5) models during the 20th century and projections during the 21st century along with seasonal variability. Greenhouse Gases (GHG) and Land Use (LU) are the major factors that gave rise to warming during the 20th century. Anthropogenic Aerosols (AA) have slowed down the warming rate. The CMIP5 projection over India shows a sharp increase in ST under Representative Concentration Pathways (RCP) 8.5 where it reaches a maximum of 5 K by the end of the 21st century. Under RCP2.6 emission scenarios, ST increases up to the year 2050 and decreases afterwards. The seasonal variability of ST during the 21st century shows significant increase during summer. Analysis of rare heat and cold events for 2080-2099 relative to a base period of 1986-2006 under RCP8.5 scenarios reveals that both are likely to increase substantially. However, by controlling the regional AA and LU change in India, a reduction in further warming over India region might be achieved