Extracting the size of the cosmic electron-positron anomaly

We isolated the anomalous part of the cosmic electron-positron flux within a Bayesian likelihood analysis. Using 219 recent cosmic ray spectral data points, we inferred the values of selected cosmic ray propagation parameters. In the context of the propagation model coded in GalProp, we found a significant tension between the electron positron related and the rest of the fluxes. Interpreting this tension as the presence of an anomalous component in the electron-positron related data, we calculated background predictions for PAMELA and Fermi-LAT based on the non-electron-positron related fluxes. We found a deviation between the data and the predicted background even when uncertainties, including systematics, were taken into account. We identified this deviation with the anomalous electron-positron contribution. We briefly compared this model independent signal to some theoretical results predicting such an anomaly.Comment: 35 pages with 4 Figures and 2 Tables. References added, accepted for publication in Ap

Women’s issues: Upward mobility through adult education

This paper addresses the issue of access and opportunity for women to advance both educationally and economically in work and profession settings through non-formal education exemplified by mentorships and non credit programming, and through formal education as exemplified by non-traditional students in higher education. The approaches to these issues will be through three separate theoretical perspectives. One perspective derives from Darkenwald, Scanlan, Valentine and Hayes who studied deterrents to participation. Another perspective derives from Rice’s work on the access of welfare women to higher education. A final perspective comes from Riley and Wrench who assert that women, in general, are denied the opportunity for mentoring relationships so often given to men in the workplace. Hence the papers address the upward mobility of women in the workplace, in rural communities and in higher education

Development and pilot testing of a parent-reported health-related quality of life measure for children on the ketogenic diet: the KetoQoL

AimThe aim of the present study was to develop a parent-reported tool that will measure health-related quality of life (HRQoL) in children following ketogenic diet (KD) therapies for refractory epilepsy once it has been pilot tested and analysed

Prevalence of malnutrition, obesity and nutritional risk of Australian paediatric inpatients: A national one-day snapshot

Aim Low prevalence rates of malnutrition at 2.5% to 4% have previously been reported in two tertiary paediatric Australian hospitals. The current study is the first to measure the prevalence of malnutrition, obesity and nutritional risk of paediatric inpatients in multiple hospitals throughout Australia. Methods Malnutrition, obesity and nutritional risk prevalence were investigated in 832 and 570 paediatric inpatients, respectively, in eight tertiary paediatric hospitals and eight regional hospitals across Australia on a single day. Malnutrition and obesity prevalence was determined using z-scores and body mass index (BMI) percentiles. High nutritional risk was determined as a Paediatric Yorkhill Malnutrition Score of 2 or more. Results The prevalence rates of malnourished, wasted, stunted, overweight and obese paediatric patients were 15%, 13.8%, 11.9%, 8.8% and 9.9%, respectively. Patients who identified as Aboriginal and Torres Strait Islander were more likely to have lower height-for-age z-scores (P < 0.01); however, BMI and weight-for-age z-scores were not significantly different. Children who were younger, from regional hospitals or with a primary diagnosis of cardiac disease or cystic fibrosis had significantly lower anthropometric z-scores (P = 0.05). Forty-four per cent of patients were identified as at high nutritional risk and requiring further nutritional assessment. Conclusions The prevalence of malnutrition and nutritional risk of Australian paediatric inpatients on a given day was much higher when compared with the healthy population. In contrast, the proportion of overweight and obese patients was less

Expanded phenotypic spectrum of neurodevelopmental and neurodegenerative disorder Bryant-Li-Bhoj syndrome with 38 additional individuals.

Bryant-Li-Bhoj syndrome (BLBS), which became OMIM-classified in 2022 (OMIM: 619720, 619721), is caused by germline variants in the two genes that encode histone H3.3 (H3-3A/H3F3A and H3-3B/H3F3B) [1-4]. This syndrome is characterized by developmental delay/intellectual disability, craniofacial anomalies, hyper/hypotonia, and abnormal neuroimaging [1, 5]. BLBS was initially categorized as a progressive neurodegenerative syndrome caused by de novo heterozygous variants in either H3-3A or H3-3B [1-4]. Here, we analyze the data of the 58 previously published individuals along 38 unpublished, unrelated individuals. In this larger cohort of 96 people, we identify causative missense, synonymous, and stop-loss variants. We also expand upon the phenotypic characterization by elaborating on the neurodevelopmental component of BLBS. Notably, phenotypic heterogeneity was present even amongst individuals harboring the same variant. To explore the complex phenotypic variation in this expanded cohort, the relationships between syndromic phenotypes with three variables of interest were interrogated: sex, gene containing the causative variant, and variant location in the H3.3 protein. While specific genotype-phenotype correlations have not been conclusively delineated, the results presented here suggest that the location of the variants within the H3.3 protein and the affected gene (H3-3A or H3-3B) contribute more to the severity of distinct phenotypes than sex. Since these variables do not account for all BLBS phenotypic variability, these findings suggest that additional factors may play a role in modifying the phenotypes of affected individuals. Histones are poised at the interface of genetics and epigenetics, highlighting the potential role for gene-environment interactions and the importance of future research