Proximity-induced ferromagnetism and chemical reactivity in few-layer VSe2 heterostructures

Among transition-metal dichalcogenides, mono and few-layers thick VSe2 has gained much recent attention following claims of intrinsic room-temperature ferromagnetism in this system, which have nonetheless proved controversial. Here, we address the magnetic and chemical properties of Fe/VSe2 heterostructure by combining element sensitive x-ray absorption spectroscopy and photoemission spectroscopy. Our x-ray magnetic circular dichroism results confirm recent findings that both native mono/few-layer and bulk VSe2 do not show intrinsic ferromagnetic ordering. Nonetheless, we find that ferromagnetism can be induced, even at room temperature, after coupling with a Fe thin film layer, with antiparallel alignment of the moment on the V with respect to Fe. We further consider the chemical reactivity at the Fe/VSe2 interface and its relation with interfacial magnetic coupling

Astrophysical S_{17}(0) factor from a measurement of d(7Be,8B)n reaction at E_{c.m.} = 4.5 MeV

Angular distribution measurements of $^2$H($^7$Be,$^7$Be)$^2$H and $^2$H($^7$Be,$^8$B)$n$ reactions at $E_{c.m.}\sim$~4.5 MeV were performed to extract the astrophysical $S_{17}(0)$ factor using the asymptotic normalization coefficient (ANC) method. For this purpose a pure, low emittance $^7$Be beam was separated from the primary $^7$Li beam by a recoil mass spectrometer operated in a novel mode. A beam stopper at 0$^{\circ}$ allowed the use of a higher $^7$Be beam intensity. Measurement of the elastic scattering in the entrance channel using kinematic coincidence, facilitated the determination of the optical model parameters needed for the analysis of the transfer data. The present measurement significantly reduces errors in the extracted $^7$Be(p,$\gamma$) cross section using the ANC method. We get $S_{17}$~(0)~=~20.7~$\pm$~2.4 eV~b.Comment: 15 pages including 3 eps figures, one figure removed and discussions updated. Version to appear in Physical Review

Community engagement interventions for communicable disease control in low- and lower- middle-income countries : evidence from a review of systematic reviews

BACKGROUND: Community engagement (CE) interventions include a range of approaches to involve communities in the improvement of their health and wellbeing. Working with communities defined by location or some other shared interest, these interventions may be important in assisting equity and reach of communicable disease control (CDC) in low and lower-middle income countries (LLMIC). We conducted an umbrella review to identify approaches to CE in communicable disease control, effectiveness of these approaches, mechanisms and factors influencing success. METHODS: We included systematic reviews that: i) focussed on CE interventions; ii) involved adult community members; iii) included outcomes relevant to communicable diseases in LLMIC; iv) were written in English. Quantitative results were extracted and synthesised narratively. A qualitative synthesis process enabled identification of mechanisms of effect and influencing factors. We followed guidance from the Joanna Briggs Institute, assessed quality with the DARE tool and reported according to standard systematic review methodology. RESULTS: Thirteen systematic reviews of medium-to-high quality were identified between June and July 2017. Reviews covered the following outcomes: HIV and STIs (6); malaria (2); TB (1); child and maternal health (3) and mixed (1). Approaches included: CE through peer education and community health workers, community empowerment interventions and more general community participation or mobilisation. Techniques included sensitisation with the community and involvement in the identification of resources, intervention development and delivery. Evidence of effectiveness of CE on health outcomes was mixed and quality of primary studies variable. We found: i) significantly reduced neonatal mortality following women's participatory learning and action groups; ii) significant reductions in HIV and other STIs with empowerment and mobilisation interventions with marginalised groups; iii) significant reductions in malaria incidence or prevalence in a small number of primary studies; iv) significant reductions in infant diarrhoea following community health worker interventions. Mechanisms of impact commonly occurred through social and behavioural processes, particularly: changing social norms, increasing social cohesion and social capacity. Factors influencing effectiveness of CE interventions included extent of population coverage, shared leadership and community control over outcomes. CONCLUSION: Community engagement interventions may be effective in supporting CDC in LLMIC. Careful design of CE interventions appropriate to context, disease and community is vital

Equivalence of Hamiltonian and Lagrangian Path Integral Quantization: Effective Gauge Theories

The equivalence of correct Hamiltonian and naive Lagrangian (Faddeev--Popov) path integral quantization (Matthews's theorem) is proven for gauge theories with arbitrary effective interaction terms. Effective gauge-boson self-interactions and effective interactions with scalar and fermion fields are considered. This result becomes extended to effective gauge theories with higher derivatives of the fields.Comment: 14 pages LaTeX, BI-TP 93/40, August 199

Effective Lagrangians with Higher Order Derivatives

The problems that are connected with Lagrangians which depend on higher order derivatives (namely additional degrees of freedom, unbound energy from below, etc.) are absent if effective Lagrangians are considered because the equations of motion may be used to eliminate all higher order time derivatives from the effective interaction term. The application of the equations of motion can be realized by performing field transformations that involve derivatives of the fields. Using the Hamiltonian formalism for higher order Lagrangians (Ostrogradsky formalism), Lagrangians that are related by such transformations are shown to be physically equivalent (at the classical and at the quantum level). The equivalence of Hamiltonian and Lagrangian path integral quantization (Matthews's theorem) is proven for effective higher order Lagrangians. Effective interactions of massive vector fields involving higher order derivatives are examined within gauge noninvariant models as well as within (linearly or nonlinearly realized) spontaneously broken gauge theories. The Stueckelberg formalism, which relates gauge noninvariant to gauge invariant Lagrangians, becomes reformulated within the Ostrogradsky formalism.Comment: 17 pages LaTeX, BI-TP 93/2

Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model

BACKGROUND: The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood–brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nano-micellar formulation of panobinostat designed for administration by convection enhanced delivery (CED). MATERIALS AND METHODS: The in vitro efficacy of panobinostat-loaded nano-micelles against rat F98, human U87-MG and M059K glioma cells and against patient-derived glioma stem cells was measured using a cell viability assay. Nano-micelle distribution in rat brain was analyzed following acute CED using rhodamine-labeled nano-micelles, and toxicity was assayed using immunofluorescent microscopy and synaptophysin enzyme-linked immunosorbent assay. We compared the survival of the bioluminescent syngenic F98/Fischer344 rat glioblastoma model treated by acute CED of panobinostat-loaded nano-micelles with that of untreated and vehicle-only-treated controls. RESULTS: Nano-micellar panobinostat is cytotoxic to rat and human glioma cells in vitro in a dose-dependent manner following short-time exposure to drug. Fluorescent rhodamine-labelled nano-micelles distribute with a volume of infusion/volume of distribution (Vi/Vd) ratio of four and five respectively after administration by CED. Administration was not associated with any toxicity when compared to controls. CED of panobinostat-loaded nano-micelles was associated with significantly improved survival when compared to controls (n=8 per group; log-rank test, P<0.001). One hundred percent of treated animals survived the 60-day experimental period and had tumour response on post-mortem histological examination. CONCLUSION: CED of nano-micellar panobinostat represents a potential novel therapeutic option for malignant glioma and warrants translation into the clinic

Efficient Syntax-Driven Lumping of Differential Equations

We present an algorithm to compute exact aggregations of a class of systems of ordinary differential equations (ODEs). Our approach consists in an extension of Paige and Tarjan’s seminal solution to the coarsest refinement problem by encoding an ODE system into a suitable discrete-state representation. In particular, we consider a simple extension of the syntax of elementary chemical reaction networks because (i) it can express ODEs with derivatives given by polynomials of degree at most two, which are relevant in many applications in natural sciences and engineering; and (ii) we can build on two recently introduced bisimulations, which yield two complementary notions of ODE lumping. Our algorithm computes the largest bisimulations in O(r⋅s⋅logs)O(r⋅s⋅log⁡s) time, where r is the number of monomials and s is the number of variables in the ODEs. Numerical experiments on real-world models from biochemistry, electrical engineering, and structural mechanics show that our prototype is able to handle ODEs with millions of variables and monomials, providing significant model reductions

Effect of vitrification techniques on post-thaw survivability and in vitro maturation of immature bovine oocytes

The present study was conducted to evaluate the effectiveness of single-step and two-step vitrification techniques on post-thaw survivability and subsequent in vitro maturation of immature bovine oocytes. In two-step vitrification method, oocytes were first equilibrated in vitrification solution-I and then vitrification solution–II of 3.5M or 4.0M and 7.0M or 8.0M glycerol + ethylene glycol (GLY+EG) cryoprotectant respectively. In single-step vitrification technique oocytes were directly exposed to final vitrification solution (7 M or 8 M of GLY+EG) for 45, 60 and 75 sec to find out the suitable exposure time based on post-thaw survivability and subsequent development in vitro. In single step vitrification the per cent morphologically normal oocyte, cumulus cells expansion and polar body formation was found to be significantly highest in oocytes of least exposure (45 seconds) period for 8M of GLY+EG. The per cent recovery of morphologically normal oocytes was found to be higher in two steps (91.81±1.42 and 91.18±1.17) than single step vitrification technique (87.94±3.49 and 85.72±2.24 of 45 sec exposure time) for both 7M and 8M of GLY+EG. The rate of cumulus cells expansion and polar body formation was significantly higher in two-steps (81.34±2.65% and 76.54±3.60% and 56.93±1.52% and 51.76±2.87%) than single step vitrification technique (57.33±3.90% and 56.91±4.66% and 33.17±5.34% and 32.70±2.91%). From the study it was concluded that two-step vitrification technique was more effective on post-thaw survivability and subsequent in vitro maturation of immature bovine oocytes