Comparison of dose volume histograms for supine and prone position in patients irradiated for prostate cancer—A preliminary study

AbstractAimTo compare DVHs for OARs in two different positions – prone and supine – for prostate cancer patients irradiated with a Tomotherapy unit.BackgroundIn the era of dose escalation, the choice of optimal patient immobilization plays an essential role in radiotherapy of prostate cancer.Materials and methodsThe study included 24 patients who were allocated to 3 risk groups based on D’Amico criteria; 12 patients represented a low or intermediate and 12 a high risk group.For each patient two treatment plans were performed: one in the supine and one in the prone position. PTV included the prostate, seminal vesicles and lymph nodes for the high risk group and the prostate and seminal vesicles for the intermediate or low risk groups. DVHs for the two positions were compared according to parameters: Dmean, D70, D50 and D20 for the bladder and rectum and Dmean, D10 for the intestine. The position accuracy was verified using daily MVCT.ResultsProne position was associated with lower doses in OARs, especially in the rectum. Despite the fact that in the entire group the differences between tested parameters were not large, the Dmean and D10 for the intestine were statistically significant. In the case of irradiation only to the prostate and seminal vesicles, the prone position allowed for substantial reduction of all tested DVH parameters in the bladder and rectum, except D20 for bladder. Moreover, the Dmean and D50 parameter differences for the bladder were statistically significant.No significant differences between positions reproducibility were demonstrated.ConclusionIn patients irradiated to prostate and seminal vesicles, the prone position may support sparing of the rectum and bladder.The reproducibility of position arrangement in both positions is comparable

Nonunion of ulnar diaphysis after Monteggia fracture of a right forearm in a 55-year-old patient - Are all methods effective? Case report

Fractures of the forearm make up about 10-14% of all fractures. Monteggia lesions account for 1-6% of the forearm fractures. The eponym “Monteggia fracture” is a term used for fracture of ulnar proximal shaft with concomitant dislocation of the radial head in the proximal radioulnar joint [1]. Its clinical symptoms are: pain, edema, local sensitivity, friction between bone fragments, deformation of the limb, loss of function in elbow joint and the forearm. Radiographs in AP and lateral views of the entire forearm, with wrist and elbow joint, are mandatory for successful diagnosis [2]. There are four types of fractures in the Bado classification system of the Monteggia lesion [3]. All Monteggia fractures in adults require surgical procedure of open reduction and internal fixation as a method of choice [4]. Delayed bone adhesion, nonunion, synostosis, instability of the radial head, nerve damage and restriction of movement are main complications of surgical intervention. We present a case of a 55-year-old patient with Monteggia fracture of a right forearm with a complication of a nonunion of the ulnar shaft, despite undergoing surgical procedure of open reduction and internal fixation. We describe consecutive methods of treatment that resulted in complete bone adhesion. Nonunion typically occurs due to technical mistakes in initial surgical intervention. Application of the correct reparative technique with autogenous bone graft and compression plates allows to fully heal nonunion of the bone

Simulation of the number of storm overflows considering changes in precipitation dynamics and the urbanisation of the catchment area: A probabilistic approach

This paper presents a probabilistic methodology that allows the study of the interactions between changes in rainfall dynamics and impervious areas in urban catchment on a long- and short-term basis. The proposed probabilistic model predict future storm overflows while taking into account the dynamics of changes in impervious areas and rainfall. In this model, a logistic regression method was used to simulate overflow resulting from precipitation events based on average rainfall intensity and impervious area. The adopted approach is universal (as it can be used in other urban catchments) and is a significant simplification of classic solutions; a hydrodynamic model is used to analyse the operation of the overflow. For the rainfall simulations, a rainfall generator based on the Monte Carlo method was used. In this method, a modification that allows the simulation of changes taking place in rainfall dynamics, including the effects of climate change, was introduced. This method provides the opportunity to expand and modify probabilistic models in which outflow from the catchment is modelled to predict the functioning of reservoirs and to design sewer networks that have the ability to deal with future rainfall dynamics, including moderate, strong, and violent downpours according to the Sumner scale. To verify the simulation results with a probabilistic model, an innovative concept using a hydrodynamic model was considered. This verification considers the changes in the impervious area in the period covered by the simulations and is limited using standard calculation procedures. In practice, the model presented in this work creates opportunities for defining the concept of sustainable development in urban catchments while taking into account the factors mentioned above. From the perspective of landscaping, this is important because it creates the opportunity to limit the impacts of climate change and area urbanization on the receiving waters.Este artículo presenta una metodología probabilística que permite el estudio de las interacciones entre cambios en la dinámica de lluvias y áreas impermeables en cuencas urbanas a largo y corto plazo. El modelo probabilístico propuesto predice futuros desbordamientos de tormentas teniendo en cuenta la dinámica de los cambios en las áreas impermeables y la lluvia. En este modelo, se utilizó un método de regresión logística para simular el desbordamiento resultante de eventos de precipitación en función de la intensidad de lluvia promedio y el área impermeable. El enfoque adoptado es universal (ya que puede ser utilizado en otras cuencas urbanas) y es una simplificación significativa de las soluciones clásicas; se utiliza un modelo hidrodinámico para analizar el funcionamiento del rebosadero. Para las simulaciones de lluvia, se utilizó un generador de lluvia basado en el método Monte Carlo . En este método se introdujo una modificación que permite simular los cambios que se están produciendo en la dinámica de las lluvias, incluyendo los efectos del cambio climático . Este método brinda la oportunidad de ampliar y modificar modelos probabilísticos en los que se modela el caudal de salida de la cuenca para predecir el funcionamiento de los embalses y diseñar redes de alcantarillado que tengan la capacidad de lidiar con la dinámica futura de las precipitaciones, incluidos aguaceros moderados, fuertes y violentos según a la escala Sumner. Para verificar los resultados de la simulación con un modelo probabilístico, se consideró un concepto innovador utilizando un modelo hidrodinámico. Esta verificación considera los cambios en el área impermeable en el período cubierto por las simulaciones y se limita utilizando procedimientos de cálculo estándar. En la práctica, el modelo presentado en este trabajo crea oportunidades para definir el concepto de desarrollo sostenible en cuencas urbanas teniendo en cuenta los factores mencionados anteriormente. Desde la perspectiva del paisajismo, esto es importante porque crea la oportunidad de limitar los impactos del cambio climático y la urbanización del área en las aguas receptoras

Early, posttraumatic, frontal instability of the knee joint deriving from injured medial collateral ligament, after total knee arthroplasty, complicated by wound dehiscence and Clostridium difficile infection in a 70-year-old patient

Gonarthrosis is a joint disease in which a balance between regenerative and degenerative processes of articular cartilage is impaired. Its main symptoms are: pain, swelling, rigidity, function restraint as well as articular deformation [1]. It is estimated that about 40% of the knee joint degeneration is a consequence of ageing of the body. 60% of remaining cases of gonarthrosis is a result of excessive strain, contusion and injury. Patients with advanced arthrosis are qualified for total arthroplasty of the knee. Medial collateral ligament (MCL) is responsible for the medial stability of the knee joint, it prevents from valgus deformity and restraints external rotation of tibia relative to the femur. Injury, most often distorting the knee, may lead to straining as well as complete rupture of the MCL [2,3]. We present a case of a 70-year-old patient with MCL injury that happened three weeks after total knee arthroplasty, complicated by wound dehiscence. Insufficiency of the medial collateral ligament in our patient had an effect in longer healing process and rehabilitation. Main treatment options are: revision surgery with use of constrained implants and injured medial collateral ligament reconstruction. Constrained implants may have reduced longevity in some patients through aseptic loosening. Our patient underwent a MCL reconstruction. Reconstruction of MCL without revision arthroplasty has good results for injured MCL after total arthroplasty of the knee

Pilon fracture of the tibia with severe complications in a 42-year-old patient – case report.

Pilon type fractures of the distal tibia are among the most difficult injuries of the lower extremity. They occur due to the axial loading injury which drives the talus into the tibial plafond, mainly because of high energy traumas such as car accidents and falls, but may arise from low energy traumas also. Due to specific conditions in the area of the injury: where skin and subcutaneous tissue is delicate, soft tissues are usually severely damaged, it is crucial to choose the correct timing for surgical intervention. There are several surgical options regarding treatment of the pilon fractures, however treatment plan of pilon fractures has not yet been unified. Surgical methods include open reduction with internal fixation and external fixation. Main purpose of the treatment of pilon fractures are the preservation of length and restoration of the joint surfaces. Great risks for the successful treatment are skin and soft tissue infections, that occur quite commonly due to specific anatomy of the fractured area. Wound infection may have potentially catastrophic consequences. Here we present a case of our 42-year-old patient, with a pilon fracture of the tibia who suffered multiple complications due to obtained tauma as well as his concurrent diseases: diabetes, alcohol and nicotine abuse, also as a result of his lack of compliance with medical advice. Despite the complications that occurred, outcome of the overall treatment was satisfactory both to the patient as well as orthopedic team. This example shows that treatment method should be chosen wisely not only on the type of the fracture, but also with patient’s ability to comply with doctors’ recommendation

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts. June 4-7, 2019, Szczyrk, Polan

Digital threats to internal security. New network subcultures, virtual reality, artificial intelligence

Niniejszy artykuł zogniskowany jest wokół analizy cyfrowych zagrożeń dla bezpieczeństwa wewnętrznego wynikających z ponowoczesnej fazy rozwoju społeczeństwa, a także postindustrialnego charakteru systemu ekonomicznego. W tym kontekście przedstawiono zmiany społeczne determinujące rozwój digitalnych zagrożeń, a także zaakcentowano neoewolucyjne fundamenty teoretyczne w postaci teorii systemu termodynamicznego oraz teorii kumulacji informacji. Aktualna transformacja charakteru interakcji w społeczeństwie została zaprezentowana przy wykorzystaniu teorii aktora-sieci. W odniesieniu do procesu subkulturyzacji opisano funkcjonowanie pięciu głównych subkultur sieciowych, na podstawie badań własnych uwypuklono związane z aktywnością sieciową ryzyko uzależnienia od Internetu, zaakcentowano również zagrożenia dla bezpieczeństwa wiążące się z użytkowaniem sieci w życiu codziennym, a także niebezpieczeństwa na polu badań nad sztuczną inteligencją. Prezentację wyżej wymienionych zależności uzupełniono analizą opinii młodzieży studenckiej na temat kierunku rozwoju technologicznego.The article is focused on the analysis of digital threats to internal security resulting from the postmodern phase of society’s development, as well as the post-industrial nature of the economic system. In this context, there were presented the social changes determining the development of digital threats and the neo-evolutionary theoretical foundations in the form of the thermodynamic system theory and the theory of information accumulation were emphasized. Current transformation of the character of interactions in the society were presented by using the actor-network theory. In reference to the subculturization process there were described the functioning of five main network subcultures, on the basis of own research, emphasized the risk of Internet addiction related to network activity, also emphasized the security threats related to the use of the network in everyday life, as well as the dangers in the field of artificial intelligence research. The presentation of the above-mentioned dependencies was supplemented with an analysis of the opinions of student youth on the direction of technological development

Anion-templated synthesis of a switchable fluorescent [2]catenane with sulfate sensing capability

Anion templation strategies have facilitated the synthesis of various catenane and rotaxane hosts capable of strong and selective binding of anions in competitive solvents. However, this approach has primarily relied on positively charged precursors, limiting the structural diversity and the range of potential applications of the anion-templated mechanically interlocked molecules. Here we demonstrate the synthesis of a rare electroneutral [2]catenane using a powerful, doubly charged sulfate template and a complementary diamidocarbazole-based hydrogen bonding precursor. Owing to the unique three-dimensional hydrogen bonding cavity and the embedded carbazole fluorophores, the resulting catenane receptor functions as a sensitive fluorescent turn-ON sensor for the highly hydrophilic sulfate, even in the presence of large excess of water. Importantly, the [2]catenane exhibits enhanced binding affinity and selectivity for sulfate over its parent macrocycle and other acyclic diamidocarbazole-based receptors. We demonstrate also, for the first time, that the co-conformation of the catenane may be controlled by reversible acid/base induced protonation and deprotonation of the sulfate anionic template. This approach pioneers a new strategy to induce molecular motion of interlocked components using switchable anionic templates

Modeling of Heavy Metal (Ni, Mn, Co, Zn, Cu, Pb, and Fe) and PAH Content in Stormwater Sediments Based on Weather and Physico-Geographical Characteristics of the Catchment-Data-Mining Approach

The processes that affect sediment quality in drainage systems show high dynamics and complexity. However, relatively little information is available on the influence of both catchment characteristics and meteorological conditions on sediment chemical properties, as those issues have not been widely explored in research studies. This paper reports the results of investigations into the content of selected heavy metals (Ni, Mn, Co, Zn, Cu, Pb, and Fe) and polycyclic aromatic hydrocarbons (PAHs) in sediments from the stormwater drainage systems of four catchments located in the city of Kielce, Poland. The influence of selected physico-geographical catchment characteristics and atmospheric conditions on pollutant concentrations in the sediments was also analyzed. Based on the results obtained, statistical models for forecasting the quality of stormwater sediments were developed using artificial neural networks (multilayer perceptron neural networks). The analyses showed varied impacts of catchment characteristics and atmospheric conditions on the chemical composition of sediments. The concentration of heavy metals in sediments was far more affected by catchment characteristics (land use, length of the drainage system) than atmospheric conditions. Conversely, the content of PAHs in sediments was predominantly affected by atmospheric conditions prevailing in the catchment. The multilayer perceptron models developed for this study had satisfactory predictive abilities; the mean absolute error of the forecast (Ni, Mn, Zn, Cu, and Pb) did not exceed 21%. Hence, the models show great potential, as they could be applied to, for example, spatial planning for which environmental aspects (i.e., sediment quality in the stormwater drainage systems) are accounted

Extended Reality in Diagnostic Imaging—A Literature Review

The utilization of extended reality (ER) has been increasingly explored in the medical field over the past ten years. A comprehensive analysis of scientific publications was conducted to assess the applications of ER in the field of diagnostic imaging, including ultrasound, interventional radiology, and computed tomography. The study also evaluated the use of ER in patient positioning and medical education. Additionally, we explored the potential of ER as a replacement for anesthesia and sedation during examinations. The use of ER technologies in medical education has received increased attention in recent years. This technology allows for a more interactive and engaging educational experience, particularly in anatomy and patient positioning, although the question may be asked: is the technology and maintenance cost worth the investment? The results of the analyzed studies suggest that implementing augmented reality in clinical practice is a positive phenomenon that expands the diagnostic capabilities of imaging studies, education, and positioning. The results suggest that ER has significant potential to improve diagnostic imaging procedures’ accuracy and efficiency and enhance the patient experience through increased visualization and understanding of medical conditions. Despite these promising advancements, further research is needed to fully realize the potential of ER in the medical field and to address the challenges and limitations associated with its integration into clinical practice