15,596 research outputs found
Intrinsic limits to gene regulation by global crosstalk
Gene regulation relies on the specificity of transcription factor (TF) - DNA
interactions. In equilibrium, limited specificity may lead to crosstalk: a
regulatory state in which a gene is either incorrectly activated due to
noncognate TF-DNA interactions or remains erroneously inactive. We present a
tractable biophysical model of global crosstalk, where many genes are
simultaneously regulated by many TFs. We show that in the simplest regulatory
scenario, a lower bound on crosstalk severity can be analytically derived
solely from the number of (co)regulated genes and a suitable parameter that
describes binding site similarity. Estimates show that crosstalk could present
a significant challenge for organisms with low-specificity TFs, such as
metazoans, unless they use appropriate regulation schemes. Strong cooperativity
substantially decreases crosstalk, while joint regulation by activators and
repressors, surprisingly, does not; moreover, certain microscopic details about
promoter architecture emerge as globally important determinants of crosstalk
strength. Our results suggest that crosstalk imposes a new type of global
constraint on the functioning and evolution of regulatory networks, which is
qualitatively distinct from the known constraints acting at the level of
individual gene regulatory elements
Strain monitoring of tapestries: results of a three-year research project
The outcomes of an interdisciplinary research project between conservators and engineers investigating the strain experienced by different areas of a tapestry are described. Two techniques were used: full-field monitoring using digital image correlation (DIC) and point measurements using optical fibre sensors. Results showed that it is possible to quantify the global strain across a discrete area of a tapestry using DIC; optical fibre and other sensors were used to validate the DIC. Strain maps created by the DIC depict areas of high and low strain and can be overlaid on images of the tapestry, creating a useful visual tool for conservators, custodians and the general public. DIC identifies areas of high strain not obvious to the naked eye. The equipment can be used in situ in a historic house. In addition the work demonstrated the close relationship between relative humidity and strain
Surface plasmon modes and the Casimir energy
We show the influence of surface plasmons on the Casimir effect between two
plane parallel metallic mirrors at arbitrary distances. Using the plasma model
to describe the optical response of the metal, we express the Casimir energy as
a sum of contributions associated with evanescent surface plasmon modes and
propagative cavity modes. In contrast to naive expectations, the plasmonic
modes contribution is essential at all distances in order to ensure the correct
result for the Casimir energy. One of the two plasmonic modes gives rise to a
repulsive contribution, balancing out the attractive contributions from
propagating cavity modes, while both contributions taken separately are much
larger than the actual value of the Casimir energy. This also suggests
possibilities to tailor the sign of the Casimir force via surface plasmons.Comment: 4 pages, 3 figures, revtex
Semiclassical Gravity Theory and Quantum Fluctuations
We discuss the limits of validity of the semiclassical theory of gravity in
which a classical metric is coupled to the expectation value of the stress
tensor. It is argued that this theory is a good approximation only when the
fluctuations in the stress tensor are small. We calculate a dimensionless
measure of these fluctuations for a scalar field on a flat background in
particular cases, including squeezed states and the Casimir vacuum state. It is
found that the fluctuations are small for states which are close to a coherent
state, which describes classical behavior, but tend to be large otherwise. We
find in all cases studied that the energy density fluctuations are large
whenever the local energy density is negative. This is taken to mean that the
gravitational field of a system with negative energy density, such as the
Casimir vacuum, is not described by a fixed classical metric but is undergoing
large metric fluctuations. We propose an operational scheme by which one can
describe a fluctuating gravitational field in terms of the statistical behavior
of test particles. For this purpose we obtain an equation of the form of the
Langevin equation used to describe Brownian motion.Comment: In REVTEX. 20pp + 4 figures(not included, available upon request)
TUTP-93-
Ultra-high-sensitivity two-dimensional bend sensor
A multicore fibre Fabry-Perot-based strain sensor interrogated with tandem interferometry for bend measurement is described. Curvature in two dimensions is obtained by measuring the difference in strain between three co-located low finesse Fabry-Perot interferometers formed in each core of the fibre by pairs of Bragg gratings. This sensor provides a responsivity enhancement of up to 30 times that of a previously reported fibre Bragg grating based sensor. Strain resolutions of 0.6 n epsilon/Hz(1/2) above 1 Hz are demonstrated, which corresponds to a curvature resolution of similar to 0.012 km(-1)/Hz(1/2)
Stochastic Spacetime and Brownian Motion of Test Particles
The operational meaning of spacetime fluctuations is discussed. Classical
spacetime geometry can be viewed as encoding the relations between the motions
of test particles in the geometry. By analogy, quantum fluctuations of
spacetime geometry can be interpreted in terms of the fluctuations of these
motions. Thus one can give meaning to spacetime fluctuations in terms of
observables which describe the Brownian motion of test particles. We will first
discuss some electromagnetic analogies, where quantum fluctuations of the
electromagnetic field induce Brownian motion of test particles. We next discuss
several explicit examples of Brownian motion caused by a fluctuating
gravitational field. These examples include lightcone fluctuations, variations
in the flight times of photons through the fluctuating geometry, and
fluctuations in the expansion parameter given by a Langevin version of the
Raychaudhuri equation. The fluctuations in this parameter lead to variations in
the luminosity of sources. Other phenomena which can be linked to spacetime
fluctuations are spectral line broadening and angular blurring of distant
sources.Comment: 15 pages, 3 figures. Talk given at the 9th Peyresq workshop, June
200
Groups of two galaxies in SDSS: implications of colours on star formation quenching time-scales
We have devised a method to select galaxies that are isolated in their dark
matter halo (N=1 systems) and galaxies that reside in a group of exactly two
(N=2 systems). Our N=2 systems are widely-separated (up to
\,200\,\,kpc), where close galaxy-galaxy interactions are not
dominant. We apply our selection criteria to two volume-limited samples of
galaxies from SDSS DR6 with -19 and -20 to study the
effects of the environment of very sparse groups on galaxy colour. For
satellite galaxies in a group of two, we find a red excess attributed to star
formation quenching of 0.15\,\,0.01 and 0.14\,\,0.01 for the -19 and
-20 samples, respectively, relative to isolated galaxies of the same stellar
mass. Assuming N=1 systems are the progenitors of N=2 systems, an
immediate-rapid star formation quenching scenario is inconsistent with these
observations. A delayed-then-rapid star formation quenching scenario with a
delay time of 3.3 and 3.7\,Gyr for the -19 and -20 samples, respectively,
yields a red excess prediction in agreement with the observations. The
observations also reveal that central galaxies in a group of two have a slight
blue excess of 0.06\,\,0.02 and 0.02\,\,0.01 for the -19 and -20
samples, respectively, relative to N=1 populations of the same stellar mass.
Our results demonstrate that even the environment of very sparse groups of
luminous galaxies influence galaxy evolution and in-depth studies of these
simple systems are an essential step towards understanding galaxy evolution in
general.Comment: 17 pages, 11 figures, accepted to MNRA
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