Who\u27s in Charge in the Inner City? The Conflict Between Efficiency and Equity in the Design of a Metropolitan Area

A circular metropolitan area consists of an inner city and a suburb. Households sort over the two jurisdictions based on public service levels and their costs of commuting to the metropolitan center. Using numerical simulations, we show (1) there typically exist two equilibria: one in which the poor form the majority in the inner city and the other in which the rich form the majority in the inner city; (2) there is an efficiency vs. equity trade-off as to which equilibrium is preferred; and (3) if the inner city contains only poor households, equity favors expanding the inner city to include rich households

A linguagem violentada e a mimese humana nas democracias espetaculares: Interlocuções com Giorgio Agamben

It is urgent that we deepen our critical analysis of the spectacular drift of current democracies. To contribute to this objective, in this essay we will analyze some aspects of Agamben´s research on spectacular democracy. In a second point we will develop an analysis of the language that, in the origin of politics, in ancient Greece, which proposed to create a new model of power based on the conviction of truth, and how this language later slid into instrumental techniques of truth in politics. In a third moment we will present the links of human mimesis with the spectacular drift of language in contemporary democracies.É urgente aprofundar as análises críticas da deriva espetacular das atuais democracias. Para contribuir com esse objetivo, no presente ensaio, analisam-se alguns aspectos das pesquisas de Agamben a respeito das democracias espetaculares. Em um segundo ponto, desenvolve-se uma análise acerca da linguagem, que, na origem da política, na Grécia antiga, propunha criar um novo modelo de poder fundamentado no convencimento da verdade, e como, posteriormente, essa linguagem deslizou-se para técnicas instrumentalizadoras da verdade, na política. Em um terceiro momento, apresentarem-se os nexos da mimese humana com a deriva espetacular da linguagem, nas democracias contemporâneas

Estilos de desarrollo, ideología e Intervención antrópica en Misiones (Argentina): Un análisis multidimensional y comparativo. 16H201

Esta es una continuación del Programa ECIS (Estudio Comparativo de los Impactos Sociales de los Grandes Proyectos de Desarrollo), constituído a partir del 2005 en el Programa de Ecología Humana (PEH). Los ejes convocantes para esta nueva etapa, son, en primer lugar, la compleción del análisis del Proyecto Yacyretá, que en el período anterior concretó la publicación de un volumen. Una segunda vertiente remite a la ideología de los movimientos sociales opuestos a la construcción de represas y a la concepción de desarrollo explícitas o implícitas en sus propuestos y su comparación con otros movimientos ecologistas (Córdoba). Asimismo, nos proponemos realizar estudios de campo de las prácticas agrícolas de los colonos asentados en áreas de la provincia incluidas en el proyecto de "corredor verde", con el objeto de analizar su compatibilidad o no con los modelos de "explotación sustentable" que se vienen manejando, así como analizar otros desarrollos recientes en el agro misionero. Finalmente, se contemplan estudios comparativos sobre desarrollo socioeconómico de minorías en la Patagonia argentina

Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort

Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms responsible for this phenotype are poorly understood. We investigated gene expression profile patterns associated with frequent exacerbations in sputum and blood cells in a well-characterised cohort. Samples from subjects from the ECLIPSE COPD cohort were used; sputum and blood samples from 138 subjects were used for microarray gene expression analysis, while blood samples from 438 subjects were used for polymerase chain reaction (PCR) testing. Using microarray, 150 genes were differentially expressed in blood (>±1.5 fold change, p≤0.01) between frequent compared to non-exacerbators. In sputum cells, only 6 genes were differentially expressed. The differentially regulated genes in blood included downregulation of those involved in lymphocyte signalling and upregulation of pro-apoptotic signalling genes. Multivariate analysis of the microarray data followed by confirmatory PCR analysis identified 3 genes that predicted frequent exacerbations; B3GNT, LAF4 and ARHGEF10. The sensitivity and specificity of these 3 genes to predict the frequent exacerbator phenotype was 88% and 33% respectively. There are alterations in systemic immune function associated with frequent exacerbations; down-regulation of lymphocyte function and a shift towards pro-apoptosis mechanisms are apparent in patients with frequent exacerbations

The evaluation of surface diffusion coefficients of gold and platinum atoms at electrochemical interfaces from combined STM-SEM imaging and electrochemical techniques

A simple method is presented for measuring the surface diffusion coefficients of Au and Pt atoms at electrodispersed electrodes of the same metals in contact with 0.5M H2SO4. The technique is based upon the time dependence of the surface roughness factor of electrodispersed metal overlayers. The method requires a model for the surface roughness of the metal structure. The model is deduced from microscopic measurements by a STM integrated into a conventional SEM microscope. This allows the relationship between the roughness factor and the area of the surface structure to be obtained. For Au and Pt in contact with an electrolyte solution, the values of our diffusion coefficients are higher than those reported in vacuum at the same temperature.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA)Facultad de Ciencias Exacta

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The evaluation of surface diffusion coefficients of gold and platinum atoms at electrochemical interfaces from combined STM-SEM imaging and electrochemical techniques

A simple method is presented for measuring the surface diffusion coefficients of Au and Pt atoms at electrodispersed electrodes of the same metals in contact with 0.5M H2SO4. The technique is based upon the time dependence of the surface roughness factor of electrodispersed metal overlayers. The method requires a model for the surface roughness of the metal structure. The model is deduced from microscopic measurements by a STM integrated into a conventional SEM microscope. This allows the relationship between the roughness factor and the area of the surface structure to be obtained. For Au and Pt in contact with an electrolyte solution, the values of our diffusion coefficients are higher than those reported in vacuum at the same temperature.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA)Facultad de Ciencias Exacta

Adaptation and Validation of the MapMe Body Image Scales in Spanish Parents of Schoolchildren

\ua9 2024 by the authors.Childhood overweight and obesity is a worldwide problem and to treat it parents’ detection has to be improved. The MapMe Body Image Scales (BIS) are a visual tool developed to improve parental perception of child weight in the United Kingdon (UK) based on British growth reference criteria. The aim of this study was to make a transcultural adaptation and validation of the MapMe BIS in Spain based on International Obesity Task Force (IOTF) cut offs A descriptive cross-sectional study was done. First, a translation and cultural adaptation was carried out. A total of 155 10–11-year-old children and their parents participated in this study. Children were measured to calculate their weight status, Body Mass Index (BMI), Body Fat Percentage (BFP) and Waist Circumference (WC), and their parents completed a purpose designed questionnaire about their perception and satisfaction of child’s body weight status using the adapted BIS. Test-retest reliability, criterion validity and concurrent validity of the adapted BIS were analyzed. This study shows that the adapted MapMe BIS has good psychometric properties and is a suitable visual scale to assess parental perception of weight status in 10 and 11-year-old children in Spain

Ex vivo Evaluation of a Liposome-Mediated Antioxidant Delivery System on Markers of Skin Photoaging and Skin Penetration

Mildred Min,1,2 Caitlin Egli,1,3 Rebecca Alonzo Bartolome,4 Raja K Sivamani1,2,5,6 1Integrative Skin Science and Research Sacramento, Sacramento, CA, USA; 2College of Medicine, California Northstate University, Elk Grove, CA, USA; 3College of Medicine, University of St. George’s, University Centre, West Indies, Grenada; 4Nalón Innova, Asturias, Spain; 5Department of Dermatology, University of California-Davis, Sacramento, CA, USA; 6Pacific Skin Institute, Sacramento, CA, USACorrespondence: Raja K Sivamani, Integrative Skin Science and Research Sacramento, 1451 River Park Dr. Suite 222, Sacramento, CA, 95815, USA, Tel +1 916-750-2463, Email [email protected]: The topical application of antioxidants has been shown to augment the skin’s innate antioxidant system and enhance photoprotection. A challenge of topical antioxidant formulation is stability and penetrability. The use of a targeted drug delivery system may improve the bioavailability and delivery of antioxidants. In this ex vivo study, we assessed the effects of the topical application of a liposome-encapsulated antioxidant complex versus a free antioxidant complex alone on skin photoaging parameters and penetrability in human skin explants.Patients and Methods: Human organotypic skin explant cultures (hOSEC) were irradiated to mimic photoaging. The encapsulated antioxidant complex and free antioxidant complex were applied topically onto the irradiated hOSEC daily for 7 days. The two control groups were healthy untreated hOSEC and irradiated hOSEC. Photoprotective efficacy was measured with pro-inflammatory cytokine (IL-6 and IL-8) and matrix metalloproteinase 9 (MMP-9) secretion. Cell viability and metabolic activity were measured via resazurin assay. Tissue damage was evaluated via lactate dehydrogenase (LDH) cytotoxicity assay. Skin penetration of the encapsulated antioxidant complex was assessed via fluorescent dye and confocal microscopy.Results: Compared to healthy skin, irradiated skin experienced increases in IL-6, IL-8 (p < 0.05), and MMP-9 (p < 0.05) secretion. After treatment with the encapsulated antioxidant complex, there was a 39.3% reduction in IL-6 secretion, 49.8% reduction in IL-8 (p < 0.05), and 38.5% reduction in MMP-9 (p < 0.05). After treatment with the free antioxidant complex, there were no significant differences in IL-6, IL-8, or MMP-9 secretion. Neither treatment group experienced significant LDH leakage or reductions in metabolic activity. Liposomes passed through the stratum corneum and into the epidermis.Conclusion: The topical application of a liposome-encapsulated antioxidant complex containing ectoin, astaxanthin-rich microalgae Haematococcus pluvialis extract, and THDA improves penetrability and restored IL-6, IL-8, and MMP-9 levels in irradiated human skin explants, which was not seen in the comparator free antioxidant complex group.Keywords: skin explants, ectoin, astaxanthin, THDA, tetrahexyldecyl ascorbat