The importance of virtual counselling in connection with the computerization of the educational and professional environment of a man

The main area of thought in this article is to describe and show the importance of virtual careers counselling in connection with the processes of computerization and informatization of man’s educational and professional environment. The starting point for the discussion on the unique way the students and workers function in an information society is understanding the idea of continuous education and its role in the process of shaping one’s career path. A very important issue of present changes and demands on the job market is also taken up. The importance of modern information technologies in the educational and professional environments of people is the basis for the thought on the need for creating and improving the virtual counselling offer. Showing its importance in the context of a lifelong process, and not only in the key moments of one’s educational and professional career, is the fi nal issue described in this article

Determinants of university graduates’ educational activity

At present work is perceived as a highly desirable value in which competence is of particular importance. Apart from economic security, a career is to be a source of satisfaction and personal fulfi lment for an individual. This situation also results in the fact that a man needs to perceive his career fl exibly, as a peculiar package of alternative professions and a lifelong retraining process. The main focus of this article is to show and emphasize the importance of a multidimensional and continuous educational activity among university graduates in the context of their careers development. The starting point for the discussion on the growing need for adult lifelong learning are the issues of labour market requirements and thus creation of new jobs – the learning organizations. An important aspect presented in this article is the description and analysis of the results of the research on the scope, determinants and prospects of educational activity taken by university graduates in the context of the respondents’ careers. The article ends with the conclusions drawn from the research and the description of the determinants of adults’ educational activity

Sudden vanishing and reappearance of nonclassical effects: General occurrence of finite-time decays and periodic vanishings of nonclassicality and entanglement witnesses

Analyses of phenomena exhibiting finite-time decay of quantum entanglement have recently attracted considerable attention. Such decay is often referred to as sudden vanishing (or sudden death) of entanglement, which can be followed by its sudden reappearance (or sudden rebirth). We analyze various finite-time decays (for dissipative systems) and analogous periodic vanishings (for unitary systems) of nonclassical correlations as described by violations of classical inequalities and the corresponding nonclassicality witnesses (or quantumness witnesses), which are not necessarily entanglement witnesses. We show that these sudden vanishings are universal phenomena and can be observed: (i) not only for two- or multi-mode but also for single-mode nonclassical fields, (ii) not solely for dissipative systems, and (iii) at evolution times which are usually different from those of sudden vanishings and reappearances of quantum entanglement.Comment: 10 pages, 3 figure

The thymidine phosphorylase as the platelet-derived endothelial cell growth factor of endometrial cancer

Abstract Objectives: The aim of the study was to assess the correlation between the activity of thymidine phosphorylase (TP) and the platelet derived-endothelial cell growth factor (PD-ECGF) expression in endometrial carcinoma. Methods: The study group consisted of 40 tissue samples taken from patients with endometrial carcinoma, who underwent surgery in First Clinic of Gynecology and Oncologic Gynecology of Medical University in Lodz. The control tissue samples were taken from patients who were operated on for non-oncologic reason. The activity of TP was measured by the spectrophotometric method in the cytosol of tumor cells, and the immunohistochemical staining of PD-ECGF was performed in the same tumors. The results of TP activity were compared with the microvessel density (MD) assessed by immunohistochemical analysis and with clinico-pathological features like tumor grade and FIGO stage. Result: A positive correlation between the enzyme activity and expression of TP/PD-ECGF protein was found. Moreover, a significantly higher TP activity was confirmed in malignant tumors from endometrial cancer patients when compared to the controls. A positive correlation between the enzyme activity and MD was also stated, but there was no connection to the grade of tumors and FIGO stage. Since the TP activity proved to be related to PD-ECGF expression and angiogenesis, we can state that TP seems to be an active form of PD-ECGF growth factor in endometrial carcinoma. This is in agreement with the results of many publications on other malignancies. The proper modulation of this activity may be useful in adjuvant therapies

Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells

loxymethylthymine was the strongest inhibitor of the TP activity in endometrium, and 1-N-allyloxymethyl-4-hydrokxy-5-nitro-6-oxopyrimidine in endometrial cancer, respectively. The most potent activators of TP in endometrial cancer was 5-bromodeoxyuridine and 1-N-allyloxymethyl-5-nitrouracil, which increased the TP activity about 100%. 5-fluorodeoxyuridine, 5-jododeoxyuridine and 2’-deoxyuridine activated the TP in statistically significant manner too, but stronger in case of endometrial cancer than in normal endometrium. The synthesized 5-bromo-6-acetyloaminouracil strongly inhibited the TP activity of endometrial cells and might be useful in reducing endometrial cancer angiogenesis. On the other hand 5-bromodeoxyuridine and the synthesized 1-N-allyloxymethyl-5-nitrouracil might increase the effect of antitumor therapy with the cytostatics. These conclusions ought to be confirmed by analyzing more tumor cases

Effect of Epilobium angustifolium and Serenoa repens extracts on regulation of non-genomic signaling pathway of kinases

Objectives: Changes of kinase activity of non-genomic cellular signaling pathway may influence the effectiveness of pharmacotherapy in case of hormone-dependent tumors. Our study investigated a possible interaction at the molecular level between an aqueous herbal extract of Epilobium angustifolium as well as a lipid-sterolic fruit extract of Serenoa repens and synthetic drugs used in the treatment of hormone-dependent cancers. Material and methods: E. angustifolium and Serenoa repens extracts were orally administered to testosteroneinduced rats for 21 days. Changes of RafA/Mapk3/Mapk1 mRNA levels were analyzed by real-time quantitative PCR using target specific primers. Results: The level of RafA mRNA slightly increased in rats receiving Epilobium angustifolium (p=0.076) and Serenoa repens (p=0.016) extracts. Administration of these extracts resulted in significantly elevated Mapk1 and Mapk3 transcripts in the investigated animals (

The influence of a standardized soybean extract (Glycine max) on the expression level of CYP3A enzymes and pregnane X receptor in in vivo model

Abstract Objective: Soybean phytoestrogens, such as genistein and daidzein, have become a popular alternative for women undergoing the treatment of menopause symptoms. These isoflavones are also commonly used in traditional medicine in the prevention and treatment of osteoporosis, cardiovascular diseases and cancer. Despite the widespread use of soybean preparations as functional foods and dietary supplements, data regarding the safety as well as interactions between herbal medicines and synthetic drugs, especially with antineoplastic agents, remain scarce. Therefore, the aim of the present study was to determine the influence of soybean extract on the expression levels of CYP3A and PXR genes using real-time PCR (RT-PCR). Materials and methods: Male Wistar rats were given a standardized soybean extract (100mg/kg p.o.) for 3 and 10 days. Total RNA isolated from the liver tissue was transcribed into cDNA. The level of CYP3A1/2 and PXR mRNAs expression was analyzed by real-time quantitative PCR using SYBR Green I dye. Results: Our findings showed that soybean extract containing 37% isoflavones resulted in a significant decrease of CYP3A1 expression level by almost 35% (