Essai de prise en compte du risque d'incendies de forêts dans un Plan d'occupation des sols réalisé en 1988.

International audienc

Urbanisme et forêt dans les Bouches-du-Rhône. Le schéma départemental de prévention des incendies de forêt : étude des poudrières.

Les grands incendies des étés 1989 et 1990 ont souligné l'imbrication entre la forêt et l'urbanisation ; 60 poudrières ont été recensées dans le département ; pour chaque commune une fiche descriptive a été établie et des solutions ont été citées

Prise en compte du risque incendie dans le cadre de l'élaboration d'un P.O.S.

Etude du P.O.S. dans la commune de Saint-Marc-Jaumegarde, boisée à 90 %, pour éviter au maximum le risque d'incendie, pour protéger le bâti (diffus) existant, prendre des mesures de prévention et de prévision pour l'urbanisation future

Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

We report the structural characterization of a new pyrazinone analogue; butrepyrazinone, which was isolated from a new actinomycete strain Verrucosispora sp. K51G recovered from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of a compound from the fermentation culture and a combination of NMR spectroscopy, high-resolution mass spectrometry and computer-aided calculations revealed that butrepyrazinone (10) possesses an unusual methylation pattern on the pyrazinone ring. Butrepyrazinone (10), however, displayed no antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains, suggesting that 10 may act as a signal molecule for this strain. Although the same molecule has been synthesized previously, this is the first report to disclose the discovery of butrepyrazinone (10) from nature

Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeterV3G and CirrhoMeterV3G, provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD