4,662 research outputs found
Cytomegalovirus (CMV) retinitis is an important problem that is being missed in HIV-positive individuals attending routine clinics in Cambodia.
Stability of constant retrial rate systems with NBU input*
We study the stability of a single-server retrial queueing system with constant retrial rate, general input and service processes. First, we present a review of some relevant recent results related to the stability criteria of similar systems. Sufficient stability conditions were obtained by Avrachenkov and Morozov (2014), which hold for a rather general retrial system. However, only in the case of Poisson input is an explicit expression provided; otherwise one has to rely on simulation. On the other hand, the stability criteria derived by Lillo (1996) can be easily computed but only hold for the case of exponential service times. We present new sufficient stability conditions, which are less tight than the ones obtained by Avrachenkov and Morozov (2010), but have an analytical expression under rather general assumptions. A key assumption is that interarrival times belongs to the class of new better than used (NBU) distributions. We illustrate the accuracy of the condition based on this assumption (in comparison with known conditions when possible) for a number of non-exponential distributions
Band gap prediction for large organic crystal structures with machine learning
Machine-learning models are capable of capturing the structure-property
relationship from a dataset of computationally demanding ab initio
calculations. Over the past two years, the Organic Materials Database (OMDB)
has hosted a growing number of calculated electronic properties of previously
synthesized organic crystal structures. The complexity of the organic crystals
contained within the OMDB, which have on average 82 atoms per unit cell, makes
this database a challenging platform for machine learning applications. In this
paper, the focus is on predicting the band gap which represents one of the
basic properties of a crystalline materials. With this aim, a consistent
dataset of 12 500 crystal structures and their corresponding DFT band gap are
released, freely available for download at https://omdb.mathub.io/dataset. An
ensemble of two state-of-the-art models reach a mean absolute error (MAE) of
0.388 eV, which corresponds to a percentage error of 13% for an average band
gap of 3.05 eV. Finally, the trained models are employed to predict the band
gap for 260 092 materials contained within the Crystallography Open Database
(COD) and made available online so that the predictions can be obtained for any
arbitrary crystal structure uploaded by a user.Comment: 10 pages, 6 figure
Online Search Tool for Graphical Patterns in Electronic Band Structures
We present an online graphical pattern search tool for electronic band
structure data contained within the Organic Materials Database (OMDB) available
at https://omdb.diracmaterials.org/search/pattern. The tool is capable of
finding user-specified graphical patterns in the collection of thousands of
band structures from high-throughput ab initio calculations in the online
regime. Using this tool, it only takes a few seconds to find an arbitrary
graphical pattern within the ten electronic bands near the Fermi level for
26,739 organic crystals. The tool can be used to find realizations of
functional materials characterized by a specific pattern in their electronic
structure, for example, Dirac materials, characterized by a linear crossing of
bands; topological insulators, characterized by a "Mexican hat" pattern or an
effectively free electron gas, characterized by a parabolic dispersion. The
source code of the developed tool is freely available at
https://github.com/OrganicMaterialsDatabase/EBS-search and can be transferred
to any other electronic band structure database. The approach allows for an
automatic online analysis of a large collection of band structures where the
amount of data makes its manual inspection impracticable.Comment: 8 pages, 8 figure
Excellent outcomes can be achieved in children on HAART under routine program conditions in Cambodia. Experience from two hospitals in Siem Reap and Takeo, Cambodia
IDENTIFICATION AND PLANT INTERACTION OF A PHYLLOBACTERIUM SP, A PREDOMINANT RHIZOBACTERIUM OF YOUNG SUGAR-BEET PLANTS
The second most abundant bacterium on the root surface of young sugar beet plants was identified as a Phyllobacterium sp. (Rhizobiaceae) based on a comparison of the results of 39 conventional identification tests, 167 API tests, 30 antibiotic susceptibility tests, and sodium dodecyl sulfate-polyacrylamide gel electrophoretic fingerprints of total cellular proteins with type strains of Phyllobacterium myrsinacearum and Phyllobacterium rubiacearum. It was found on 198 of 1,100 investigated plants between the 2nd and 10th leaf stage on three different fields in Belgium and one field in Spain. Densities ranged from 2 × 10(4) to 2 × 10(8) CFU/g of root. Five isolates exerted a broad-spectrum in vitro antifungal activity. DNA-DNA hybridizations showed that Phyllobacterium sp. does not contain DNA sequences that are homologous with the attachment genes chvA, chvB, the transferred-DNA (T-DNA) hormone genes iaaH and ipt from Agrobacterium tumefaciens, iaaM from A. tumefaciens and Pseudomonas savastanoi, or the nitrogenase genes nifHDK from Klebsiella pneumoniae. Phyllobacterium sp. produces indolylacetic acid in in vitro cultures and induces auxinlike effects when cocultivated with callus tissue of tobacco. When Phyllobacterium sp. was transformed with a Ti plasmid derivative, it gained the capacity to induce tumors on Kalanchoe daigremontiana. The potential role of Phyllobacterium sp. in this newly recognized niche is discussed
YhjA - An Escherichia coli trihemic enzyme with quinol peroxidase activity
Belgian Federal Science Policy Office (Belspo) (grant to BD, IAP7/44, iPROS project). co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).The trihemic bacterial cytochrome c peroxidase from Escherichia coli, YhjA, is a membrane-anchored protein with a C-terminal domain homologous to the classical bacterial peroxidases and an additional N-terminal (NT) heme binding domain. Recombinant YhjA is a 50 kDa monomer in solution with three c-type hemes covalently bound. Here is reported the first biochemical and spectroscopic characterization of YhjA and of the NT domain demonstrating that NT heme is His63/Met125 coordinated. The reduction potentials of P (active site), NT and E hemes were established to be −170 mV, +133 mV and +210 mV, respectively, at pH 7.5. YhjA has quinol peroxidase activity in vitro with optimum activity at pH 7.0 and millimolar range KM values using hydroquinone and menadiol (a menaquinol analogue) as electron donors (KM = 0.6 ± 0.2 and 1.8 ± 0.5 mM H2O2, respectively), with similar turnover numbers (kcat = 19 ± 2 and 13 ± 2 s−1, respectively). YhjA does not require reductive activation for maximum activity, in opposition to classical bacterial peroxidases, as P heme is always high-spin 6-coordinated with a water-derived molecule as distal axial ligand but shares the need for the presence of calcium ions in the kinetic assays. Formation of a ferryl Fe(IV) = O species was observed upon incubation of fully oxidized YhjA with H2O2. The data reported improve our understanding of the biochemical properties and catalytic mechanism of YhjA, a three-heme peroxidase that uses the quinol pool to defend the cells against hydrogen peroxide during transient exposure to oxygenated environments.publishersversionpublishe
Using usability-tests to improve language match of a web-based system for digital triage in primary care
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