Pathways of rural development in Madagascar

This paper is based on community-level data from 188 villages in rural Madagascar. The survey that was conducted in 1997 made extensive use of long-term recall questions ascertaining changes during the past 10 years in rice yields, wages, population, soil fertility, and other pertinent variables of rural development. We find that—on average for all villages—the yields of irrigated rice, the major food crop, and real agricultural wages declined, while the communities expanded their upland area by nearly a quarter and experienced deteriorating fertility of their upland soils. These patterns are consistent with the wide-held belief that rural areas in Madagascar have witnessed increased poverty, economic stagnation, and a continued degradation of the natural resources. Yet, the five agroecological regions in our sample exhibit quite different patterns of rural development, and at least one of them has experienced increases in yields and wages. From a policy perspective, it is important to better understand the driving forces of such diverse rural change. The overall decline in rural wages over the past 10 years is expected to have contributed to increased poverty, food insecurity and malnutrition in rural areas, as rural wage laborers traditionally belong to the poorest of the poor in Madagascar. In this paper, we present an econometric analysis of the determinants of and interdependencies between the three components of sustainable development: economic growth, environmental sustainability, and poverty alleviation.Crop yields. ,Econometric models. ,Poverty alleviation. ,Rural development projects ,

Pathways of rural development in Madagascar

This paper is based on community-level data from 188 villages in rural Madagascar. The survey that was conducted in 1997 made extensive use of long-term recall questions ascertaining changes during the past 10 years in rice yields, wages, population, soil fertility, and other pertinent variables of rural development. We find that—on average for all villages—the yields of irrigated rice, the major food crop, and real agricultural wages declined, while the communities expanded their upland area by nearly a quarter and experienced deteriorating fertility of their upland soils. These patterns are consistent with the wide-held belief that rural areas in Madagascar have witnessed increased poverty, economic stagnation, and a continued degradation of the natural resources. Yet, the five agroecological regions in our sample exhibit quite different patterns of rural development, and at least one of them has experienced increases in yields and wages. From a policy perspective, it is important to better understand the driving forces of such diverse rural change. The overall decline in rural wages over the past 10 years is expected to have contributed to increased poverty, food insecurity and malnutrition in rural areas, as rural wage laborers traditionally belong to the poorest of the poor in Madagascar. In this paper, we present an econometric analysis of the determinants of and interdependencies between the three components of sustainable development: economic growth, environmental sustainability, and poverty alleviation.Crop yields. ,Econometric models. ,Poverty alleviation. ,Rural development projects ,

Recommendations for neonatologist performed echocardiography in Europe: Consensus Statement endorsed by European Society for Paediatric Research (ESPR) and European Society for Neonatology (ESN)

Contains fulltext : 171351.pdf (Publisher’s version ) (Open Access

AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model

Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because of their restricted blood–brain barrier (BBB) penetration. Here, we propose a gene transfer strategy based on BBB-crossing adeno-associated virus (AAV)-based vectors to deliver VHH directly into the CNS. As a proof-of-concept, we explored the potential of AAV-delivered VHH to inhibit BACE1, a well-characterized target in Alzheimer’s disease. First, we generated a panel of VHHs targeting BACE1, one of which, VHH-B9, shows high selectivity for BACE1 and efficacy in lowering BACE1 activity in vitro. We further demonstrate that a single systemic dose of AAV-VHH-B9 produces positive long-term (12 months plus) effects on amyloid load, neuroinflammation, synaptic function, and cognitive performance, in the AppNL-G-F Alzheimer’s mouse model. These results constitute a novel therapeutic approach for neurodegenerative diseases, which is applicable to a range of CNS disease targets