3,731 research outputs found
Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.
ABSTRACT Linopirdine [DuP 996, 3,-1-phenylindolin-2-one], a putative cognition enhancing drug, increases acetylcholine release in rat brain tissue and improves performance in animal models of learning and memory. The mechanism whereby linopirdine enhances acetylcholine release has been proposed to involve inhibition of the M-type K Ï© current (I M ). Our study examines the selectivity of linopirdine for I M by determining its effects on other ionic currents present in rat hippocampal CA 1 neurons using patch clamp techniques. Linopirdine was found to block voltage-gated, calcium-activated and leak K Ï© currents in a dose-dependent manner. Of the seven currents measured, linopirdine was most selective for I M with an IC 50 of 2.4 Ïź 0.4 M, followed by I C (measured as a medium afterhyperpolarization tail current, I mAHP ) with an IC 50 of 16.3 Ïź 2.
Draft Genome Sequence of Burkholderia sp. MR1, a Methylarsenate-Reducing Bacterial Isolate from Florida Golf Course Soil
To elucidate the environmental organoarsenical biocycle, we isolated a soil organism, Burkholderia sp. MR1, which reduces relatively nontoxic pentavalent methylarsenate to the more toxic trivalent methylarsenite, with the goal of identifying the gene for the reductase. Here, we report the draft genome sequence of Burkholderia sp. MR1
Chiral Anomaly and
Measurement of the process has revealed a possible conflict
with what should be a solid prediction generated by the chiral anomaly. We show
that inclusion of appropirate energy-momentum dependence in the matrix element
reduces the discrepancy.Comment: 8 page standard Latex fil
Radiative force from optical cycling on a diatomic molecule
We demonstrate a scheme for optical cycling in the polar, diatomic molecule
strontium monofluoride (SrF) using the X ^2\Sigma^+\toA^2\Pi_{1/2} electronic
transition. SrF's highly diagonal Franck-Condon factors suppress vibrational
branching. We eliminate rotational branching by employing a quasi-cycling
type transition in conjunction with magnetic field remixing
of dark Zeeman sublevels. We observe cycling fluorescence and deflection
through radiative force of an SrF molecular beam using this scheme. With
straightforward improvements our scheme promises to allow more than
photon scatters, possibly enabling the direct laser cooling of SrF
Dealing with mobility: Understanding access anytime, anywhere
The rapid and accelerating move towards the adoption and use of mobile technologies has increasingly provided people and organisations with the ability to work away from the office and on the move. The new ways of working afforded by these technologies are often characterised in terms of access to information and people âanytime, anywhereâ. This paper presents a study of mobile workers that highlights different facets of access to remote people and information, and different facets of anytime, anywhere. Four key factors in mobile work are identified from the study: the role of planning, working in âdead timeâ, accessing remote technological and informational resources, and monitoring the activities of remote colleagues. By reflecting on these issues, we can better understand the role of technology and artefact use in mobile work and identify the opportunities for the development of appropriate technological solutions to support mobile workers
GALEX UV Color Relations for Nearby Early-Type Galaxies
We use GALEX/optical photometry to construct color-color relationships for
early-type galaxies sorted by morphological type. We have matched objects in
the GALEX GR1 public release and the first IR1.1 internal release, with the RC3
early-type galaxies having a morphological type -5.5<T<-1.5 with mean error in
T<1.5, and mean error on (B-V)T<0.05. After visual inspection of each match, we
are left with 130 galaxies with a reliable GALEX pipeline photometry in the
far-UV and near-UV bands. This sample is divided into Ellipticals (-5.5<T<-3.5)
and Lenticulars (-3.5<T<-1.5). After correction for the Galactic extinction,
the color-color diagrams FUV-NUV vs. (B-V)_{Tc} are plotted for the two
subsamples. We find a tight anti-correlation between the FUV-NUV and (B-V)_{Tc}
colors for Ellipticals, the UV color getting bluer when the (B-V)_{Tc} get
redder. This relationship very likely is an extension of the color-metallicity
relationship into the GALEX NUV band. We suspect that the main source of the
correlation is metal line blanketing in the NUV band. The FUV-NUV vs B-V
correlation has larger scatter for lenticular galaxies; we speculate this
reflects the presence of low level star formation. If the latter objects (i.e.
those that are blue both in FUV-NUV and B-V) are interpreted as harboring
recent star formation activity, this would be the case for a few percent (~4%)
of Ellipticals and ~15% of Lenticulars; this would make about 10% of early-type
galaxies with residual star formation in our full sample of 130 early-type
galaxies. We also plot FUV-NUV vs. the Mg_2 index and central velocity
dispersion. We find a tight anti-correlation between FUV-NUV and the Mg_2
index(...).Comment: 25 pages, 5 figures, accepted for publication in ApJS (abstract
abridged), typos corrected in section 2.
Leadership in the British civil service: an interpretation
This article is essentially a polemic. The argument is that when politicians and officials now talk of âleadershipâ in the British civil service they do not use that word in the way in which it was previously used. In the past leading civil servants, acting in partnership with ministers and within constitutional constraints, exercised leadership in the sense of setting example, inspiring confidence and encouraging loyalty. The loosening of traditional constitutional patterns, the marginalization of senior officials in the policy process and the emergence of business methods as the preferred model for public Âadministration have led to a political and administrative environment in which leadership in the British civil service is now about encouraging patterns of behaviour which fit in with these changes. Leadership skills are now about âdeliveryâ; they are not about motivation. It is time for politicians, officials and scholars to be open about this
Renormalization Group Running of Lepton Mixing Parameters in See-Saw Models with Flavor Symmetry
We study the renormalization group running of the tri-bimaximal mixing
predicted by the two typical flavor models at leading order. Although the
textures of the mass matrices are completely different, the evolution of
neutrino mass and mixing parameters is found to display approximately the same
pattern. For both normal hierarchy and inverted hierarchy spectrum, the quantum
corrections to both atmospheric and reactor neutrino mixing angles are so small
that they can be neglected. The evolution of the solar mixing angle
depends on and neutrino mass spectrum, the deviation
from its tri-bimaximal value could be large. Taking into account the
renormalization group running effect, the neutrino spectrum is constrained by
experimental data on in addition to the self-consistency
conditions of the models, and the inverted hierarchy spectrum is disfavored for
large . The evolution of light-neutrino masses is approximately
described by a common scaling factor.Comment: 23 pages, 6figure
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