621 research outputs found
Annual Research Review: Umbrella synthesis of meta-analyses on child maltreatment antecedents and interventions: differential susceptibility perspective on risk and resilience
Child maltreatment in the family context is a prevalent and pervasive phenomenon in many modern societies. The global perpetration of child abuse and neglect stands in stark contrast to its almost universal condemnation as exemplified in the United Nationās Convention on the Rights of the Child. Much work has been devoted to the task of prevention, yet a grand synthesis of the literature is missing. Focusing on two core elements of prevention, that is, antecedents for maltreatment and the effectiveness of (preventative) interventions, we performed an umbrella review of meta-analyses published between January 1, 2014, and December 17, 2018. Meta-analyses were systematically collected, assessed, and integrated following a uniform approach to allow their comparison across domains. From this analysis of thousands of studies including almost 1.5 million participants, the following risk factors were derived: parental experience of maltreatment in his or her own childhood (dĀ =.47), low socioeconomic status of the family (dĀ =.34), dependent and aggressive parental personality (dĀ =.45), intimate partner violence (dĀ =.41), and higher baseline autonomic nervous system activity (dĀ =.24). The effect size for autonomic stress reactivity was not significant (dĀ =Ā ā.10). The umbrella review of interventions to prevent or reduce child maltreatment showed modest intervention effectiveness (dĀ =.23 for interventions targeting child abuse potential or families with self-reported maltreatme
Entangling power and operator entanglement in qudit systems
We establish the entangling power of a unitary operator on a general
finite-dimensional bipartite quantum system with and without ancillas, and give
relations between the entangling power based on the von Neumann entropy and the
entangling power based on the linear entropy. Significantly, we demonstrate
that the entangling power of a general controlled unitary operator acting on
two equal-dimensional qudits is proportional to the corresponding operator
entanglement if linear entropy is adopted as the quantity representing the
degree of entanglement. We discuss the entangling power and operator
entanglement of three representative quantum gates on qudits: the SUM, double
SUM, and SWAP gates.Comment: 8 pages, 1 figure. Version 3: Figure was improved and the MS was a
bit shortene
Who and when should we screen for prostate cancer? Interviews with key opinion leaders
Prostate cancer screening using prostate-specific antigen (PSA) is highly controversial. In this Q & A, Guest Editors for BMC Medicine's 'Spotlight on Prostate Cancer' article collection, Sigrid Carlsson and Andrew Vickers, invite some of the world's key opinion leaders to discuss who, and when, to screen for prostate cancer. In response to the points of view from the invited experts, the Guest Editors summarize the experts' views and give their own personal opinions on PSA screening
He Structure and Mechanisms of He Backward Elastic Scattering
The mechanism of He backward elastic scattering is studied.
It is found that the triangle diagrams with the subprocesses He,
He and He, where and
denote the singlet deuteron and diproton pair in the state,
respectively, dominate in the cross section at 0.3-0.8 GeV, and their
contribution is comparable with that for a sequential transfer of a pair
at 1-1.5 GeV.
The contribution of the , estimated on the basis of the spectator
mechanism of the He reaction, increases the HeHe cross section by one order of magnitude as compared to the
contribution of the deuteron alone.
Effects of the initial and final states interaction are taken into account.Comment: 17 pages, Latex, 4 postscript figures, expanded version, accepted by
Physical Review
Emergency repair of inguinal hernia in the premature infant is associated with high direct medical costs
_Purpose:_ Inguinal hernia repair is frequently performed in premature infants. Evidence on optimal management and timing of repair, as well as related medical costs is still lacking. The objective of this study was to determine the direct medical costs of inguinal hernia, distinguishing between premature infants who had to undergo an emergency procedure and those who underwent elective inguinal hernia repair.
_Methods:_ This cohort study based on medical records concerned premature infants with inguinal hernia who underwent surgical repair within 3 months after birth in a tertiary academic childrenās hospital between January 2010 and December 2013. Two groups were distinguished: patients with incarcerated inguinal hernia requiring emergency repair and patients who underwent elective repair. Real medical costs were calculated by multiplying the volumes of healthcare use with corresponding unit prices. Nonparametric bootstrap techniques were used to derive a 95 % confidence interval (CI) for the difference in mean costs.
_Results:_ A total of 132 premature infants were included in the analysis. Emergency surgery was performed in 29 %. Costs of hospitalization comprised 65 % of all costs. The total direct medical costs amounted to ā¬7418 per premature infant in the emergency repair group versus ā¬4693 in the elective repair group. Multivariate analysis showed a difference in costs of ā¬1183 (95 % CI ā1196; 3044) in favor of elective repair after correction for potential risk factors.
_Conclusion:_ Emergency repair of inguinal hernia in premature infants is more expensive than elective repair, even after correction for multiple confounders. This deserves to b
The price of rapid exit in venture capital-backed IPOs
This paper proposes an explanation for two empirical puzzles surrounding initial public offerings (IPOs). Firstly, it is well documented that IPO underpricing increases during āhot issueā periods. Secondly, venture capital (VC) backed IPOs are less underpriced than non-venture capital backed IPOs during normal periods of activity, but the reverse is true during hot issue periods: VC backed IPOs are more underpriced than non-VC backed ones. This paper shows that when IPOs are driven by the initial investorās desire to exit from an existing investment in order to finance a new venture, both the value of the new venture and the value of the existing firm to be sold in the IPO drive the investorās choice of price and fraction of shares sold in the IPO. When this is the case, the availability of attractive new ventures increases equilibrium underpricing, which is what we observe during hot issue periods. Moreover, I show that underpricing is affected by the severity of the moral hazard problem between an investor and the firmās manager. In the presence of a moral hazard problem the degree of equilibrium underpricing is more sensitive to changes in the value of the new venture. This can explain why venture capitalists, who often finance firms with more severe moral hazard problems, underprice IPOs less in normal periods, but underprice more strongly during hot issue periods. Further empirical implications relating the fraction of shares sold and the degree of underpricing are presented
Generation of 3 spinocerebellar ataxia type 1 (SCA1) patient-derived induced pluripotent stem cell lines LUMCi002-A, B, and C and 2 unaffected sibling control induced pluripotent stem cell lines LUMCi003-A and B
Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by a CAG repeat expansion in exon 8 of the ATXN1 gene. We generated induced pluripotent stem cells (hiPSCs) from a SCA1 patient and his non-affected sister by using non-integrating Sendai Viruses (SeV). The resulting hiPSCs are SeVfree, express pluripotency markers, display a normal karyotype, retain the mutation (length of the CAG repeat expansion in the ATXN1 gene) and are able to differentiate into the three germ layers in vitro
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