239 research outputs found
Productive efficiency and density and viscosity studies of biodiesels from vegetable oil mixtures
Received: January 31st, 2021 ; Accepted: April 10th, 2021 ; Published: April 29th, 2021 ; Correspondence: [email protected] in Brazil the minimum content of biodiesel in mixtures is 11% and,
according to Brazilian laws, the goal is to reach 15% in volume in diesel fuel available for final
consumers by 2023. Therefore, studies about different matrices of biodiesel and distinct mixtures
are essential. The present work had two goals, the first one was to analyse physico-chemical
properties of 16 biofuels produced from soybean and cotton oils, using S10 diesel, in mixtures
B8, B10, B20 and B30. The second goal was to verify the vantages and disadvantages of biodiesel
production through prior mixing of the oils, before and after the transesterification process. All
biofuels produced presented results of specific mass values at 20 °C and kinematic viscosity at
40 °C within the limits established by ANP Resolution no 30/2016 and International Resolutions.
The soybean B20 biofuel showed the best overall results, with the second highest production
yield of 65.36%, the fifth lowest kinematic viscosity with 3.48 mm s
-1
. The mixture of soybean
and cotton oils before the transesterification process presented the highest production yield when
compared with the production from a single oil or biodiesel mixtures. The results found proved
to be satisfactory and corroborate to continue with the increase of biodiesel in the mixture with
diesel to B15 until 2023 and support the possibility of planning for a gradual increase of this
mixture in the following years
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1
Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation
of harmful mutations in the human population. We hypothesized that men with spermatogenic impairment, a disease with
unknown genetic architecture and a common cause of male infertility, are enriched for rare deleterious mutations
compared to men with normal spermatogenesis. After assaying genomewide SNPs and CNVs in 323 Caucasian men with
idiopathic spermatogenic impairment and more than 1,100 controls, we estimate that each rare autosomal deletion
detected in our study multiplicatively changes a manâs risk of disease by 10% (OR 1.10 [1.04â1.16], p,261023), rare X-linked
CNVs by 29%, (OR 1.29 [1.11â1.50], p,161023), and rare Y-linked duplications by 88% (OR 1.88 [1.13â3.13], p,0.03). By
contrasting the properties of our case-specific CNVs with those of CNV callsets from cases of autism, schizophrenia, bipolar
disorder, and intellectual disability, we propose that the CNV burden in spermatogenic impairment is distinct from the
burden of large, dominant mutations described for neurodevelopmental disorders. We identified two patients with
deletions of DMRT1, a gene on chromosome 9p24.3 orthologous to the putative sex determination locus of the avian ZW
chromosome system. In an independent sample of Han Chinese men, we identified 3 more DMRT1 deletions in 979 cases of
idiopathic azoospermia and none in 1,734 controls, and found none in an additional 4,519 controls from public databases.
The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human
spermatogenic failure (frequency of 0.38% in 1306 cases and 0% in 7,754 controls, p = 6.261025). Our study identifies other
recurrent CNVs as potential causes of idiopathic azoospermia and generates hypotheses for directing future studies on the
genetic basis of male infertility and IVF outcomes.This work was partially funded by the Portuguese Foundation for Science and Technology FCT/MCTES (PIDDAC) and co-financed by European funds (FEDER) through the COMPETE program, research grant PTDC/SAU-GMG/101229/2008. IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology, and Higher Education and is partially supported by FCT. AML is the recipient of a postdoctoral fellowship from FCT (SFRH/BPD/73366/2010). CO is supported by a grant from the United States National Institutes of Health (R01 HD21244), JDS is supported by Damon Runyon Clinical Investigator Award, Alex's Lemonade Stand Foundation Epidemiology Award, and the Eunice Kennedy Shriver Children's Health Research Career Development Award NICHD 5K12HD001410. Support for humans studies and specimens were provided by the NIH/NIDDK George M. O'Brien Center for Kidney Disease Kidney Translational Research Core (P30DK079333) grant to Washington University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
InfluĂȘncia de diferentes extratos aquosos de plantas medicinais no desenvolvimento de Colletotrichum gloeosporioides e de Fusarium moniliforme
Growth and essential oil production by Martianthus leucocephalus grown under the edaphoclimatic conditions of Feira de Santana, Bahia, Brazil
Florescimento e frutificação de mangueira (Mangifera indica L.) Cv. Rosa promovidos por diferentes doses de paclobutrazol
ModificaçÔes no atendimento de enfermagem hospitalar decorrentes do Sistema Ănico de SaĂșde (SUS)
Efeito da aplicação de terbufos nas populaçÔes de trĂȘs fitonematĂłides ectoparasitos em cana-de-açĂșcar
A de novo paradigm for male infertility
Genetics of Male Infertility Initiative (GEMINI) consortium: Donald F. Conrad, Liina Nagirnaja, Kenneth I. Aston, Douglas T. Carrell, James M. Hotaling, Timothy G. Jenkins, Rob McLachlan, Moira K. OâBryan, Peter N. Schlegel, Michael L. Eisenberg, Jay I. Sandlow, Emily S. Jungheim, Kenan R. Omurtag, Alexandra M. Lopes, Susana Seixas, Filipa Carvalho, Susana Fernandes, Alberto Barros, JoĂŁo Gonçalves, Iris Caetano, Graça Pinto, SĂłnia Correia, Maris Laan, Margus Punab, Ewa Rajpert-De Meyts, Niels JĂžrgensen, Kristian Almstrup, Csilla G. Krausz & Keith A. Jarvi.De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness.
We hypothesize that de novo mutations play an important role in severe male infertility and
explain a portion of the genetic causes of this understudied disorder. To test this hypothesis, we
utilize trio-based exome sequencing in a cohort of 185 infertile males and their unaffected parents.
Following a systematic analysis, 29 of 145 rare (MAF < 0.1%) protein-altering de novo mutations
are classified as possibly causative of the male infertility phenotype. We observed a significant
enrichment of loss-of-function de novo mutations in loss-of-function-intolerant genes (p-value =
1.00 Ă 10â5) in infertile men compared to controls. Additionally, we detected a significant
increase in predicted pathogenic de novo missense mutations affecting missense-intolerant genes
(p-value = 5.01 Ă 10â4) in contrast to predicted benign de novo mutations. One gene we identify,
RBM5, is an essential regulator of male germ cell pre-mRNA splicing and has been previously
implicated in male infertility in mice. In a follow-up study, 6 rare pathogenic missense mutations
affecting this gene are observed in a cohort of 2,506 infertile patients, whilst we find no such
mutations in a cohort of 5,784 fertile men (p-value = 0.03). Our results provide evidence for the
role of de novo mutations in severe male infertility and point to new candidate genes affecting
fertility.This project was funded by The Netherlands Organization for Scientific Research (918-15-667) to J.A.V. as well as an Investigator Award in Science from the Wellcome Trust (209451) to J.A.V. a grant from the Catherine van Tussenbroek Foundation to M.S.O. a grant from MERCK to R.S. a UUKi Rutherford Fund Fellowship awarded to B.J.H. and the German Research Foundation Clinical Research Unit âMale Germ Cellsâ (DFG, CRU326) to C.F. and F.T. This project was also supported in part by funding from the Australian National Health and Medical Research Council (APP1120356) to M.K.O.B., by grants from the National Institutes of Health of the United States of America (R01HD078641 to D.F.C. and K.I.A., P50HD096723 to D.F.C.) and from the Biotechnology and Biological Sciences Research Council (BB/S008039/1) to D.J.E.info:eu-repo/semantics/publishedVersio
AbundĂąncia de Stomoxys calcitrans (Diptera: Muscidae) em diferentes subprodutos canavieiros
Indicação de cultivares de feijoeiro-comum baseada na avaliação conjunta de diferentes épocas de semeadura
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