Qualidade de vida de indivíduos com HIV: revisão integrativa / Quality of living of individuals with HIV integration review

 A qualidade de  vida de pacientes vivendo com HIV/AIDS é essencial, tendo em vista o caso específico dos adolescentes é ainda mais importante porque o jovem além de lidar com a resistência e a aceitação da doença, deve também enfrentar os conflitos da puberdade.O presente trabalho tem como objetivo realizar uma revisão integrativa em relação a qualidade de vida dos pacientes com HIV. Trata-se de um estudo de revisão integrativa realizado no período de 2016 a 2017, utilizando-se o banco de dados Medline e Lilacs. Apesar do impacto da infecção pelo HIV/AIDS na saúde psicológica e nas relações sociais dos indivíduos infectados, assim como no domínio físico, o uso da TARV provocou consequências positivas na saúde psicológica, proporcionando a desconstrução da ideia de morte advinda ao diagnóstico de portador do HIV/AIDS e a construção de melhores perspectivas de vida. A adesão ao tratamento em HIV/AIDS está relacionada a um aumento da sobrevida e de sua qualidade. Porém deve-se respeitar a posição pessoal do portador para fazer ou não o tratamento

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Síntese do material mesoporoso MCM-41 usando esponja de água-doce como fonte de sílica

Fresh water sponge was used as a silica source for the synthesis of MCM-41 via the hydrothermal process. The silica was extracted from the sponge by washing with nitric acid and piranha solution. Synthesis of MCM-41 was performed at 100 °C for 5 days and the procedure was optimized, with modifications made to the leaching temperature of the silica and the synthesis of mesoporous material, which was characterized by XRD, FT-IR, SEM and adsorption of N2. The optimal result was achieved at a temperature of 135 °C for 3 days, showing ordered mesoporous material with a surface area of 1080 m² g-1

Toxicidade, atividade antioxidante e caracterização fitoquímica das raízes e folhas de Coccoloba mollis.

Coccoloba mollis é uma planta medicinal utilizada em Londrina, Paraná Brasil. O extrato das raízes apresentou  maior atividade contra a Artemia salina (CL50 68.5 microg/mL) do que o extrato das folhas (CL50 1342 microg mL) e demonstrou boa atividade quando comparada com o controle positivo [K2CrO4 (16.24 microg /mL)]. A avaliação do potencial antioxidante pelo método do radical livre difenilpicrilidrazil-DPPH dos extratos das raízes e das folhas exibiu resultado semelhante ao obtido com o BHT (Butylated hydroxytoluene = 2,6-Di-terc-butil-metil fenol).  Na caracterização química as substâncias identificadas no extrato das folhas foram uma mistura de hidrocarbonetos de cadeias longas, ácidos carboxílicos e a 3-taraxerona. Do extrato das raízes foram identificadas duas antraquinonas (emodina e fisciona). A quimioprospecção farmacognóstica revelou a presença de flavonóides e taninos nas folhas e nas raízes e de antraquinonas somente nas raízes. Os resultados da análise foram negativos para as classes de alcalóides, cumarinas, saponinas e fenóis simples.  Concluímos que a identificação da emodina e fisciona nos extratos das raízes corroboram com o uso popular atribuído a este fitoterápico na região de Londrina

Toxicity, antioxidant activity and phytochemical characterization of Coccoloba mollis roots and leaves

Coccoloba mollis is a plant that is used in medicine in Londrina, Brazil. The root extract showed stronger activity against A. salina (68.5 μg/mL) than did the leaf extract (1342 μg mL), and demonstrated good activity when compared with the positive control (16.24 μg /mL). The antioxidant potential (Diphenylpicrylhydrazyl – DPPH) of root and leaf extracts was comparable to that of commonly used BHT (butylated hydroxytoluene). In the chemical characterization the compounds identified were a mixture of long chain hydrocarbons, carboxyl esters and 3-taraxerone from leaf ethanolic extract and two anthraquinones (emodin and physcion) from the root one. Phytochemical screening using pharmacognostic methodology revealed the presence of flavonoids and tannins in leaves and roots. Anthraquinones only in the roots. While this analysis resulted negative for alkaloids, coumarins, saponins and simple phenolics. We conclude that the identified emodin and physcion in roots extract, corroborate with the anti-stress action and the use for memory loss attributed by popular use of this medicinal plant in the Londrina region

Chemosystematic evaluation of Amazonian freshwater sponges

Freshwater sponges can be considered a promising new source of bioactive compounds for the pharmaceutical industry; however, the research on their chemical composition is still in the incipient stage. We evaluated the most endemic Amazonian freshwater sponge species from the Drulia and Metania genera by untargeted metabolomic approaches, based on UHPCL-HRMS, in order to identify chemical markers and explore the diversity of specialized metabolites. The use of untargeted approaches allowed us to observe subsets of metabolites that enabled the characterization of, not only each genus, but also, of each species. Freshwater sponge species presented themselves as rich sources of fatty acids and sterols, which were putatively identified. These metabolites were suggested as chemical markers for further targeted metabolomic studies