Next Edition of IHO S-57 (Edition 4): Much more than ENCs

The primary goal for the next edition of S-57 (Edition 4) is to support a greater variety of hydrographic-related digital data sources, products, and customers. This includes matrix and raster data, 3-D and time-varying data (x, y, z, and time), and new applications that go beyond the scope of traditional hydrography (e.g., high-density bathymetry, seafloor classification, marine GIS). It will also enable the use of web-based services for data discovery, browsing, query, analysis, and transfer. S-57 Edition 4.0 will not be an incremental revision of Edition 3.1. Edition 4 will be a new standard that includes both additional content and a new data exchange format. Due to the world-wide prominence of ISO standards, IHO S-57 will conform to the “ISO way” of standards development. However, alignment with the ISO 19100 series of geographic standards will require a re-structuring of S-57 Edition 4. More specifically, this requires a new framework, and a new (or revised) set of terms used to describe the components of S-57 Edition 4.0. The present intention is to release Edition 4.0 in late 2006. Edition 3.1 will continue to be valid for many years to come -- even after Edition 4.0 has been released. Since most ECDIS equipment use ENC data conforming to the ENC Product Specification contained in S-57 Edition 3.1, Hydrographic Offices should continue to produce Edition 3.1 ENC data in order to continue to improve world-wide ENC coverage. Current plans are to release a new ENC Product Specification approximately one year after publication of S-57 Edition 4.0

IHO S-100: The New Hydrographic Geospatial Standard for Marine Data and Information

The International Hydrographic Organization (IHO) is an intergovernmental consultative and technical organization established in 1921 to support the safety of navigation, and to contribute to the protection of the marine environment. One of its primary roles is to establish and maintain appropriate standards to assist in the proper and efficient use of hydrographic data and information. This paper describes the new IHO Geospatial Standard for Hydrographic Data to be known as S-100, together with the Geospatial Information Infrastructure (GII) that is in the course of development and implementation by the IHO. In both cases, details have yet to be finalised – for example, the first draft of S-100 – IHO Geospatial Standard for Hydrographic Data was only released for stakeholder comment in March 2008 and S-100 is not expected to be an active standard until at least 2009 or 2010. Nevertheless, the concepts and supporting organisational framework behind the GII are already beginning to take shape. The purpose of this paper is to draw attention to what is happening and thereby promote comment and the active involvement of both existing and potential stakeholders in the development and implementation of both the IHO GII and S-100

Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma

Protein arginine methyltransferase 5 (PRMT5) is over‐expressed in a wide variety of cancers and is implicated as having a key oncogenic role, achieved in part through its control of the master transcription regulator E2F1. We investigated the relevance of PRMT5 and E2F1 in neuroblastoma (NB) and found that elevated expression of PRMT5 and E2F1 occurs in poor prognosis high‐risk disease and correlates with an amplified Myelocytomatosis viral‐related oncogene, neuroblastoma‐derived (MYCN) gene. Our results show that MYCN drives the expression of splicing factor genes that, together with PRMT5 and E2F1, lead to a deregulated alternative RNA splicing programme that impedes apoptosis. Pharmacological inhibition of PRMT5 or inactivation of E2F1 restores normal splicing and renders NB cells sensitive to apoptosis. Our findings suggest that a sustained cancer‐relevant alternative RNA splicing programme desensitises NB cells to apoptosis, and identify PRMT5 as a potential therapeutic target for high‐risk disease

Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Here, we show that Passerini reactions are especially suited for the preparation of drug delivery materials, as with relatively few steps, polymers can be synthesized with functionality installed enabling drug conjugation and encapsulation, self-assembly into micellar or vesicular architectures, and with facile attachment triggerable chemistries. The polymers can be made with a variety of building blocks and assemble into nanoparticles, which are rapidly internalized in triple negative breast cancer (TNBC) cells. In addition, the polymers transport drug molecules efficiently through 3D cell cultures, and when designed with chemistries allowing pH-mediated release, exhibit greater efficacy against TNBC cells compared to the parent drug