De la instrucció a l’aprenentatge. Un nou paradigma per a l’educació universitària

S’està produint un canvi de paradigma en l’educació superior nord-americana. El paradigma que ha regit als centres universitaris fins ara concep la universitat com una institució que té per objecte proporcionar ensenyament. De manera subtil però intensa, s’està evolucionant cap a un nou paradigma que entén que la finalitat de la universitat és produir aprenentatge. Aquest canvi suposa una modificació profunda de totes les dimensions de l’educació superior

From Teaching to Learning: A New Paradigm for Undergraduate Education

Two alternative paradigms for undergraduate education are compared; one holds teaching as its purpose, the other learning. The natures of the two paradigms are examined on the following dimensions: mission and purposes, criteria for success, teaching and learning structures, underlying learning theory, concepts of productivity and methods of funding, and faculty and staff roles in instruction and governance

Natural fermion mass hierarchy and mixings in family unification

We present an SU(9) model of family unification with three light chiral families, and a natural hierarchy of charged fermion masses and mixings. The existence of singlet right handed neutrions with masses about two orders of magnitude smaller than the GUT scale, as needed to understand the light neutrinos masses via the see-saw mechanism, is compelling in our model.Comment: 7 pages, no figur

A Note on the Economic Implications of A Focused Tourism Event: Bikers in Myrtle Beach

As we have graphically seen since September 11, 2001, areas which depend heavily upon tourism as a primary source of income face a host of challenges. South Carolina\u27s Grand Strand area is a good example of just such an area. A number of focused tourism-related events intended to attract a certain segment of the population have evolved over the years. Two such events revolve around the attraction of motorcyclists. One occurs during early to mid-May (with a burgeoning repeat presence in the Fall), while the other occurs over Memorial Day weekend. Both events have proven to be successful in terms of attracting participants, but are also seen as being somewhat problematic. Of course, proof of economic success rests with demonstrating the overall impact that each event has on the area. This study seeks to examine spending patterns of three important and relatively diverse tourist groups (i.e., including tourists who would ordinarily be attracted to the area regardless of the event) to gain some appreciation for possible benefits or pitfalls

Fluvial Erosion Hazard Mitigation

Fluvial erosion—erosion that occurs along a river—is a major threat to infrastructure, and most commonly to roads. This presentation provides an overview of the Indiana Fluvial Erosion Hazard Mitigation Manual, which was recently developed on behalf of the Indiana Silver Jackets. The manual provides a framework for analyzing, designing, and post-construction management / maintenance for fluvial erosion hazard mitigation projects in Indiana

Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate

INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically modified amino acids in the form of isomerized aspartate and that its liberation due to osteoarthritis (OA)-related cartilage degradation could reflect OA severity. METHODS: Articular cartilage and synovial fluid were obtained from 14 randomly selected total knee arthroplasty cases (56 to 79 years old) and non-arthritis cartilage from 8 trauma cases (51 to 83 years old). Paired lesional cartilage and non-lesioned OA cartilage were graded histologically using a modified Mankin system. Paired cartilage and synovial fluids were assayed for isomerized aspartate, phosphate-buffered saline/EDTA (ethylenediaminetetraacetic acid) extractable glycosaminoglycans, and total protein. Macroscopically normal non-lesioned OA cartilage was separated into superficial and deep regions when cartilage thickness was at least 3 mm (n = 6). RESULTS: Normalized to cartilage wet weight, normal cartilage and deep non-lesioned OA cartilage contained significantly (P < 0.05) more isomerized aspartate than superficial non-lesioned OA cartilage and lesioned cartilage. Synovial fluid isomerized aspartate correlated positively (R2 = 0.53, P = 0.02) and glycosaminoglycans correlated negatively (R2 = 0.42, P = 0.04) with histological OA lesion severity. Neither synovial fluid isomerized aspartate nor glycosaminoglycans nor total protein correlated with histological scores of non-lesioned areas. CONCLUSIONS: We show for the first time that human cartilage and synovial fluid contain measurable quantities of an isomerized amino acid and that synovial fluid concentrations of isomerized aspartate reflected severity of histological OA. Further assessment is warranted to identify the cartilage proteins containing this modification and to assess the functional consequences and biomarker applications of this analyte in OA

A New Way to Measure the World's Protected Area Coverage

Protected areas are effective at stopping biodiversity loss, but their placement is constrained by the needs of people. Consequently protected areas are often biased toward areas that are unattractive for other human uses. Current reporting metrics that emphasise the total area protected do not account for this bias. To address this problem we propose that the distribution of protected areas be evaluated with an economic metric used to quantify inequality in income— the Gini coefficient. Using a modified version of this measure we discover that 73% of countries have inequitably protected their biodiversity and that common measures of protected area coverage do not adequately reveal this bias. Used in combination with total percentage protection, the Gini coefficient will improve the effectiveness of reporting on the growth of protected area coverage, paving the way for better representation of the world's biodiversity

Classification of phase transitions and ensemble inequivalence, in systems with long range interactions

Systems with long range interactions in general are not additive, which can lead to an inequivalence of the microcanonical and canonical ensembles. The microcanonical ensemble may show richer behavior than the canonical one, including negative specific heats and other non-common behaviors. We propose a classification of microcanonical phase transitions, of their link to canonical ones, and of the possible situations of ensemble inequivalence. We discuss previously observed phase transitions and inequivalence in self-gravitating, two-dimensional fluid dynamics and non-neutral plasmas. We note a number of generic situations that have not yet been observed in such systems.Comment: 42 pages, 11 figures. Accepted in Journal of Statistical Physics. Final versio

Of CP and other Gauge Symmetries in String Theory

We argue that \CP is a gauge symmetry in string theory. As a consequence, \CP cannot be explicitly broken either perturbatively or non-pertubatively; there can be no non-perturbative \CP-violating parameters. String theory is thus an example of a theory where all $\theta$ angles arise due to spontaneous \CP violation, and are in principle calculable.Comment: 8 page

Levofloxacin Cures Experimental Pneumonic Plague in African Green Monkeys

Yersinia pestis is the causative agent of bubonic plague as well as a rare severe form known as primary pneumonic plague resulting from the inhalation of contaminated aerosols. The relative ease of aerosol preparation and high virulence makes Y. pestis a dangerous bioweapon. The current study describes the treatment of established pneumonic plague with the widely available, broad-spectrum fluoroquinolone antibiotic levofloxacin in a nonhuman primate model. African green monkeys inhaled a target dose of 100 lethal doses for 50% of animals (LD50) and were monitored for fever and vital signs by telemetry. Fever was the first sign of illness, correlating with bacteremia but preceding radiographic pneumonia, and initiated intravenous levofloxacin treatment in doses designed to mimic antibiotic levels achieved in humans. All animals treated with saline died and all animals completing 10 days of treatment survived, with resolution of high fever within 24–48 hours. We conclude that levofloxacin may be an appropriate broad-spectrum antibiotic for presumptive therapy in an aerosolized bioweapons attack and should be studied for treatment of bubonic plague