Non-LTE treatment of molecules in the photospheres of cool stars

We present a technique to treat systems with very many levels, like molecules, in non-LTE. This method is based on a superlevel formalism coupled with rate operator splitting. Superlevels consist of many individual levels that are assumed to be in LTE relative to each other. The usage of superlevels reduces the dimensionality of the rate equations dramatically and, thereby, makes the problem computationally more easily treatable. Our superlevel formalism retains maximum accuracy by using direct opacity sampling (dOS) when calculating the radiative transitions and the opacities. We developed this method in order to treat molecules in cool dwarf model calculations in non-LTE. Cool dwarfs have low electron densities and a radiation field that is far from a black body radiation field, both properties may invalidate the conditions for the common LTE approximation. Therefore, the most important opacity sources, the molecules, need to be treated in non-LTE. As a case study we applied our method to carbon monoxide. We find that our method gives accurate results since the conditions for the superlevel method are very well met for molecules. Due to very high collisional cross sections with hydrogen, and the high densities of H_2 the population of CO itself shows no significant deviation from LTE.Comment: AASTeX v50, 35 pages including 12 figures, accepted by Ap

Проект установки получения синтез-газа

ВКР 91 страницу, 6 рисунков, 40 таблиц, 24 литературных источника. Ключевые слова: синтез-газ, конверсия, применение синтез-газа, сырье, природный газ, технологическая схема, производство, метан, метанол. Объект разработки: производство синтез-газа методом паровой каталитической конверсии природного газа. Цель работы: изучение всех физико - химических свойств процесса и их влияния на протекание реакции, а также конструирование основного аппарата установки получения синтез - газа. В результате исследования выполнен расчет материального и теплового балансов, также конструктивный и механический расчеты, на основании которых был выполнен чертеж основного аппарата. ВКР выполнена на кафедре ТОВПМ ст. группы 2Д2А Якимовой В.А., под руководством к.х.н. Мананковой А.А.The final qualifying work contains 91 page, 6 figures, 40 tables and 24 literature sources. Content words are conversion, synthesis gas. The object of the development is the production of synthesis gas by catalytic steam reforming of natural gas. The mission is the study of physical - chemical properties of the process and their influence on the reaction, as well as the construction of the main unit installation producing synthesis - gas. The study was carried out payment of material and heat balances, the constructive and mechanical calculations, drawing on the basis of which the main unit was made. The final qualifying work carried out at the Department of TOVPM student group 2D2A Vera Yakimova, under the leadership of Candidate of Chemical Sciences Ann Manankova

The three lipocalins of egg-white: only Ex-FABP inhibits siderophore-dependent iron sequestration by Salmonella Enteritidis

Salmonella Enteritidis is the most prevalent food-borne pathogen associated with egg-related outbreaks in the European Union. During egg colonization, S. Enteritidis must resist the powerful anti-bacterial activities of egg white (EW) and overcome ovotransferrin-imposed iron-restriction (the most important anti-bacterial mechanism of EW). Many pathogens respond to iron restriction by secreting iron-chelating chemicals called siderophores but EW contains a siderophore-sequestering “lipocalin” protein (Ex-FABP) that is predicted to limit the usefulness of siderophores in EW. S. Enteritidis produces two siderophores: enterobactin, which is strongly bound by Ex-FABP; and the di-glucosylated enterobactin-derivative, salmochelin (a so-called “stealth” siderophore), which is not recognized by Ex-FABP. Thus, production of salmochelin may allow S. Enteritidis to escape Ex-FABP-mediated growth inhibition under iron restriction although it is unclear whether its EW concentration is sufficient to inhibit pathogens. Further, two other lipocalins (Cal-γ and α-1-ovoglycoprotein) are found in EW but their siderophore sequestration potential remains unexplored. In addition, the effect of EW lipocalins on the major EW pathogen, S. Enteritidis, has yet to be reported. We overexpressed and purified the three lipocalins of EW and investigated their ability to interact with the siderophores of S. Enteritidis, as well as their EW concentrations. The results show that Ex-FABP is present in EW at concentrations (5.1 μM) sufficient to inhibit growth of a salmochelin-deficient S. Enteritidis mutant under iron restriction but has little impact on the salmochelin-producing wildtype. Neither Cal-γ nor α-1-ovoglycoprotein bind salmochelin or enterobactin, nor do they inhibit iron-restricted growth of S. Enteritidis. However, both are present in EW at significant concentrations (5.6 and 233 μM, respectively) indicating that α-1-ovoglycoprotein is the 4th most abundant protein in EW, with Cal-γ and Ex-FABP at 11th and 12th most abundant. Further, we confirm the preference (16-fold) of Ex-FABP for the ferrated form (Kd of 5.3 nM) of enterobactin over the iron-free form (Kd of 86.2 nM), and its lack of affinity for salmochelin. In conclusion, our findings show that salmochelin production by S. Enteritidis enables this key egg-associated pathogen to overcome the enterobactin-sequestration activity of Ex-FABP when this lipocalin is provided at levels found in EW

Spectral Properties of Brown Dwarfs and Hot Jupiters

Brown dwarfs bridge the gap between the stellar and planetary mass regimes. Evolving from conditions very similar to the lowest-mass stars, the atmospheres of older brown dwarfs closely resemble those expected in close-in extrasolar giant planets, and with cooler BDs still being discovered, more and more approach the properties of gas giants at wider separation. Interpreting the spectra of BDs is therefore a crucial step towards understanding and predicting the spectral and thermal properties of EGPs. Essential properties of substellar atmospheres are massive molecular line-blanketing and the condensation of species with decreasing Teff, changing the chemical equilibrium composition and causing absorption from dust grains. More complex details involve the distribution of dust clouds over the surface giving rise to temporal variability, and possible deviations from chemical equilibrium conditions. In the case of close-in EGPs and some BDs in binary systems, the effect of irradiation from the primary significantly affects the spectral properties and thermal evolution.Comment: 12 pages, 6 figures, Review to be published in "High Resolution Infrared Spectroscopy in Astronomy", Proceedings of the ESO Workshop Held in Garching, Germany, 18-21 Nov., 2003, eds. H.U. Kaeufl, R. Siebenmorgen, & A. Moorwood, ESO Astrophysics Symposia http://www.eso.org/gen-fac/meetings/ekstasy2003

Amyloid positron emission tomography in sporadic cerebral amyloid angiopathy: A systematic critical update

Sporadic cerebral amyloid angiopathy (CAA) is a very common small vessel disease of the brain, showing preferential and progressive amyloid-βdeposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. CAA now encompasses not only a specific cerebrovascular pathological trait, but also different clinical syndromes - including spontaneous lobar intracerebral haemorrhage (ICH), dementia and ‘amyloid spells’ - an expanding spectrum of brain parenchymal MRI lesions and a set of diagnostic criteria – the Boston criteria, which have resulted in increasingly detecting CAA during life. Although currently available validated diagnostic criteria perform well in multiple lobar ICH, a formal diagnosis is currently lacking unless a brain biopsy is performed. This is partly because in practice CAA MRI biomarkers provide only indirect evidence for the disease. An accurate diagnosis of CAA in different clinical settings would have substantial impact for ICH risk stratification and antithrombotic drug use in elderly people, but also for sample homogeneity in drug trials. It has recently been demonstrated that vascular (in addition to parenchymal) amyloid-βdeposition can be detected and quantified in vivo by positron emission tomography (PET) amyloid tracers. This non-invasive approach has the potential to provide a molecular signature of CAA, and could in turn have major clinical impact. However, several issues around amyloid-PET in CAA remain unsettled and hence its diagnostic utility is limited. In this article we systematically review and critically appraise the published literature on amyloid-PET (PiB and other tracers) in sporadic CAA. We focus on two key areas: (a) the diagnostic utility of amyloid-PET in CAA and (b) the use of amyloid-PET as a window to understand pathophysiological mechanism of the disease. Key issues around amyloid-PET imaging in CAA, including relevant technical aspects are also covered in depth. A total of six small-scale studies have addressed (or reported data useful to address) the diagnostic utility of late-phase amyloid PET imaging in CAA, and one additional study dealt with early PiB images as a proxy of brain perfusion. Across these studies, amyloid PET imaging has definite diagnostic utility (currently tested only in probable CAA): it helps rule out CAA if negative, whether compared to healthy controls or to hypertensive deep ICH controls. If positive, however, differentiation from underlying incipient Alzheimer's disease (AD) can be challenging and so far, no approach (regional values, ratios, visual assessment) seems sufficient and specific enough, although early PiB data seem to hold promise. Based on the available evidence reviewed, we suggest a tentative diagnostic flow algorithm for amyloid-PET use in the clinical setting of suspected CAA, combining early- and late-phase PiB-PET images. We also identified ten mechanistic amyloid-PET studies providing early but promising proof-of-concept data on CAA pathophysiology and its various manifestations including key MRI lesions, cognitive impairment and large scale brain alterations. Key open questions that should be addressed in future studies of amyloid-PET imaging in CAA are identified and highlighted

Обоснование выбора электродвигателя и схемы его включения для системы точного поддержания скорости

Рассматривается применение в системах точного поддержания скорости различных синхронных электродвигателей. В результате сравнения рекомендовано применение в таких системах конденсаторного синхронного реактивного двигателя с трехфазными обмотками статора. Это позволяет упростить и удешевить систему точного электропривода и повысить ее надежность

Non-LTE Effects of Na I in the Atmosphere of HD209458b

The recent announcement that sodium absorption has been observed in the atmosphere of HD209458b, the only EGP observed to transit its parent star, is the first direct detection of an EGP atmosphere. We explore the possibility that neutral sodium is {\em not} in local thermodynamic equilibrium (LTE) in the outer atmosphere of irradiated EGPs and that the sodium concentration may be underestimated by models that make the LTE assumption. Our results indicate that it may not be necessary to invoke excessive photoionization, low metallicity, or even high altitude clouds to explain the observations