35 research outputs found

    Parents, children and the porous boundaries of the sexual family in law and popular culture

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    This article focuses on a perceived ideological overlap between popular cultural and judicial treatments of sex and conjugality that contributes to a discursive construction of parenthood and parenting. The author perceives that in both legal and popular cultural texts, there is a sense in which notions of ā€˜naturalā€™ childhood are discursively constituted as being put at risk by those who reproduce outside of dominant sexual norms, and that signs of normative sexuality (typically in the form of heterosexual coupling) may be treated as a sign of safety. These ideas are rooted in ancient associations between fertility, sexuality and femininity that can also be traced in the historical development of the English language. With the help of commentators such as Martha Fineman, the article situates parents and children within a discourse of family which prioritises conjugality, with consequences for the ways in which the internal and external boundaries of families are delineated

    Thermomechanical erosion modelling of Baydaratskaya Bay, Russia with COSMOS

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    Rapid coastal erosion threatens Arctic coastal infrastructure, including communities and industrial installations. Erosion of permafrost depends on numerous processes, including thermal and mechanical behaviour of frozen and unfrozen soil, nearshore hydrodynamics, atmospheric forcing, and the presence of sea ice. The quantification and numerical modelling of these processes is essential to predicting Arctic coastal erosion. This paper presents a case study of Baydaratskaya Bay, Russia, using the COSMOS numerical model to predict thermal-mechanical erosion. In particular, this study focuses on thermoabrasional rather than thermodenudational processes. A field dataset of onshore thermal and mechanical soil characteristics was supplemented by sources from the literature to serve as input for the model. A detailed sensitivity analysis has been conducted to determine the influence of key parameters on coastal erosion rates at the study site. This case study highlights the need for expanded data collection on Arctic coastlines and provides direction for future investigations

    Formulations and Reformulations in Integer Programming

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    The timetable constrained distance minimization problem

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    Abstract. We define the timetable constrained distance minimization problem (TCDMP) which is a sports scheduling problem applicable for tournaments where the total travel distance must be minimized. The problem consists of finding an optimal home-away assignment when the opponents of each team in each time slot are given. We present an integer programming, a constraint programming formulation and describe two alternative solution methods: a hybrid integer programming/constraint programming approach and a branch and price algorithm. We test all four solution methods on benchmark problems and compare the performance. Furthermore, we present a new heuristic solution method called the circular traveling salesman approach (CTSA) for solving the traveling tournament problem. The solution method is able to obtain high quality solutions almost instantaneously, and by applying the TCDMP, we show how the solutions can be further improved

    Continuous dosing of a novel contraceptive vaginal ring releasing NestoroneĀ® and estradiol: Pharmacokinetics from a dose-finding study

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    Background: As part of a program to develop a novel estradiol-releasing contraceptive vaginal ring (CVR), we evaluated the pharmacokinetic (PK) profile of CVRs releasing segesterone acetate (NestoroneĀ® (NES)) combined with one of three different estradiol (E2) doses. Study design: A prospective, double-blind, randomized, multi-centered study to evaluate a 90-day CVR releasing NES [200 Ī¼g/day] plus E2, either 10 Ī¼g/day, 20 Ī¼g/day, or 40 Ī¼g/day in healthy reproductive-age women with regular cycles. Participants provided blood samples twice weekly for NES and E2 levels during the first 60 days (ring 1) and the last 30 days (ring 2) of use. A subset underwent formal PK assessments at ring initiation, ring exchange (limited PK), and study completion. Results: The main study enrolled 197 women; 22 participated in the PK substudy. Baseline characteristics between the main and PK participants were comparable, with an average BMI of 25.8 kg/m2 (SD 4.3). In the PK substudy, all three rings showed similar NES PK: mean area under the curve (AUC_(0ā€“72)) 34,181 pg*day/mL; concentration maximum (Cmax) 918 pg/mL; time to maximum concentration (Tmax) 3.5 h. For E2, the Cmax occurred at 2 h, and was significantly higher with the 20 ug/day ring (mean 390 pg/mL); 10ug/day, 189 pg/mL, p=.003; 40 ug/day, 189 pg/mL, p \u3c .001), and declined rapidly to ā‰¤ 50 pg/mL for all doses by 24 h. For all subjects, the median E2 levels remained under 35 pg/mL during treatment. Conclusion: PK parameters of NES were not affected when paired with different doses of E2, but E2 levels from all three doses were lower than anticipated and no dose response was observed. Implications: While these novel estradiol-releasing combination contraceptive vaginal rings provided sustained release of contraceptive levels of Nestorone over 90 days, the E2 levels achieved were not consistent with bone protection, and a doseā€“response was not observed
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