Modelling the ArH+^+ emission from the Crab Nebula

We have performed combined photoionization and photodissociation region (PDR) modelling of a Crab Nebula filament subjected to the synchrotron radiation from the central pulsar wind nebula, and to a high flux of charged particles; a greatly enhanced cosmic ray ionization rate over the standard interstellar value, $\zeta_0$, is required to account for the lack of detected [C I] emission in published Herschel SPIRE FTS observations of the Crab Nebula. The observed line surface brightness ratios of the OH$^+$ and ArH$^+$ transitions seen in the SPIRE FTS frequency range can only be explained with both a high cosmic ray ionization rate and a reduced ArH$^+$ dissociative recombination rate compared to that used by previous authors, although consistent with experimental upper limits. We find that the ArH$^+$/OH$^+$ line strengths and the observed H$_2$ vibration-rotation emission can be reproduced by model filaments with $n_{\rm{H}} = 2 \times 10^4$ cm$^{-3}$, $\zeta = 10^7 \zeta_0$ and visual extinctions within the range found for dusty globules in the Crab Nebula, although far-infrared emission from [O I] and [C II] is higher than the observational constraints. Models with $n_{\rm{H}} = 1900$ cm$^{-3}$ underpredict the H$_2$ surface brightness, but agree with the ArH$^+$ and OH$^+$ surface brightnesses and predict [O I] and [C II] line ratios consistent with observations. These models predict HeH$^+$ rotational emission above detection thresholds, but consideration of the formation timescale suggests that the abundance of this molecule in the Crab Nebula should be lower than the equilibrium values obtained in our analysis.Comment: Accepted by MNRAS. Author accepted manuscript. Accepted on 05/09/2017. Deposited on 05/09/1

Atomic Gas in Debris Discs

We have conducted a search for optical circumstellar absorption lines in the spectra of 16 debris disc host stars. None of the stars in our sample showed signs of emission line activity in either H$_{\alpha}$, Ca II or Na I, confirming their more evolved nature. Four stars were found to exhibit narrow absorption features near the cores of the photospheric Ca II and Na I D lines (when Na I D data were available). We analyse the characteristics of these spectral features to determine whether they are of circumstellar or interstellar origins. The strongest evidence for circumstellar gas is seen in the spectrum of HD110058, which is known to host a debris disc observed close to edge-on. This is consistent with a recent ALMA detection of molecular gas in this debris disc, which shows many similarities to the $\beta$ Pictoris system.Comment: Accepted 13/12/2016. Received 2/12/2016; Deposited on 22/11/2016. - 13 Pages, 9 Figures - MNRAS Advance Access published December 15, 201

Upper estimate of martingale dimension for self-similar fractals

We study upper estimates of the martingale dimension $d_m$ of diffusion processes associated with strong local Dirichlet forms. By applying a general strategy to self-similar Dirichlet forms on self-similar fractals, we prove that $d_m=1$ for natural diffusions on post-critically finite self-similar sets and that $d_m$ is dominated by the spectral dimension for the Brownian motion on Sierpinski carpets.Comment: 49 pages, 7 figures; minor revision with adding a referenc

A research protocol for developing a Point-Of-Care Key Evidence Tool 'POCKET': a checklist for multidimensional evidence reporting on point-of-care in vitro diagnostics.

INTRODUCTION: Point-of-care in vitro diagnostics (POC-IVD) are increasingly becoming widespread as an acceptable means of providing rapid diagnostic results to facilitate decision-making in many clinical pathways. Evidence in utility, usability and cost-effectiveness is currently provided in a fragmented and detached manner that is fraught with methodological challenges given the disruptive nature these tests have on the clinical pathway. The Point-of-care Key Evidence Tool (POCKET) checklist aims to provide an integrated evidence-based framework that incorporates all required evidence to guide the evaluation of POC-IVD to meet the needs of policy and decisionmakers in the National Health Service (NHS). METHODS AND ANALYSIS: A multimethod approach will be applied in order to develop the POCKET. A thorough literature review has formed the basis of a robust Delphi process and validation study. Semistructured interviews are being undertaken with POC-IVD stakeholders, including industry, regulators, commissioners, clinicians and patients to understand what evidence is required to facilitate decision-making. Emergent themes will be translated into a series of statements to form a survey questionnaire that aims to reach a consensus in each stakeholder group to what needs to be included in the tool. Results will be presented to a workshop to discuss the statements brought forward and the optimal format for the tool. Once assembled, the tool will be field-tested through case studies to ensure validity and usability and inform refinement, if required. The final version will be published online with a call for comments. Limitations include unpredictable sample representation, development of compromise position rather than consensus, and absence of blinding in validation exercise. ETHICS AND DISSEMINATION: The Imperial College Joint Research Compliance Office and the Imperial College Hospitals NHS Trust R&D department have approved the protocol. The checklist tool will be disseminated through a PhD thesis, a website, peer-reviewed publication, academic conferences and formal presentations

Dissociating effects of acute photic stress on spatial, episodic-like and working memory in the rat.

Adaptively responding to acute stress has been of great importance for human and animal survival. However, for our species, stress-related disorders are putting an ever-increasing burden on healthcare systems. It is thus crucial to understand the basic processes and cognitive changes associated with acute stress. Here, we examined the effects of acute stress exposure on spatial (water maze) and memory (delayed match to sample and episodic-memory-like tasks) performance. We found striking performance deficits in stressed animals navigating in the water maze. We also found, in an episodic-like memory task, striking object-location deficits, but not in temporal-object association learning in stressed animals. Finally, no differences were apparent for any delay periods (up to 30 s) in a delayed match to sample task. Taken together, these results show a strong differential effect of acute stress on differing memory processes

Transition density of diffusion on Sierpinski gasket and extension of Flory's formula

Some problems related to the transition density u(t,x) of the diffusion on the Sierpinski gasket are considerd, based on recent rigorous results and detailed numerical calculations. The main contents are an extension of Flory's formula for the end-to-end distance exponent of self-avoiding walks on the fractal spaces, and an evidence of the oscillatory behavior of u(t,x) on the Sierpinski gasket.Comment: 11 pages, REVTEX, 2 postscript figure

Atomic and molecular interstellar absorption lines toward the high galactic latitude stars HD~141569 and HD~157841 at ultra-high resolution

We present ultra-high resolution (0.32 km/s) spectra obtained with the 3.9m Anglo-Australian Telescope (AAT) and Ultra-High-Resolution Facility (UHRF), of interstellar NaI D1, D2, Ca II K, K I and CH absorption toward two high galactic latitude stars HD141569 and HD157841. We have compared our data with 21-cm observations obtained from the Leiden/Dwingeloo HI survey. We derive the velocity structure, column densities of the clouds represented by the various components and identify the clouds with ISM structures seen in the region at other wavelengths. We further derive abundances, linear depletions and H2 fractional abundances for these clouds, wherever possible. Toward HD141569, we detect two components in our UHRF spectra : a weak, broad component at - 15 km/s, seen only in CaII K absorption and another component at 0 km/s, seen in NaI D1, D2, Ca II K, KI and CH absorption. In the case of the HD157841 sightline, a total of 6 components are seen on our UHRF spectra in NaI D1, D2 Ca II K, K I and CH absorption. 2 of these 6 components are seen only in a single species.Comment: 16 pages, Latex, 4 figures, ps files Astrophysical Journal (in press

Strong UV and X-ray variability of the Narrow Line Seyfert 1 Galaxy WPVS 007 -- on the nature of the X-ray low state

We report on multi-wavelength observations of the X-ray transient Narrow Line Seyfert 1 (NLS1) galaxy WPVS 007. The galaxy was monitored with Swift between October 2005 and July 2013, after it had undergone a dramatic drop in its X-ray flux earlier. For the first time, we are able to repeatedly detect this NLS1 in X-rays again. This increased number of detections in the last couple of years may suggest that the strong absorber that has been found in this AGN is starting to become leaky, and may eventually disappear. The X-ray spectra obtained for WPVS 007 are all consistent with a partial covering absorber model. A spectrum based on the data during the extreme low X-ray flux states shows that the absorption column density is of the order of 4 x 10^23 cm^-2 with a covering fraction of 95%. WPVS 007 also displays one of the strongest UV variabilities seen in Narrow Line Seyfert 1s. The UV continuum variability anti-correlates with the optical/UV slope alpha-UV which suggests that the variability primarily may be due to reddening. The UV variability time scales are consistent with moving dust `clouds' located beyond the dust sublimation radius of approximately 20 ld. We present for the first time near infrared JHK data of WPVS 007, which reveal a rich emission-line spectrum. Recent optical spectroscopy does not indicate significant variability in the broad and FeII emission lines, implying that the ionizing continuum seen by those gas clouds has not significantly changed over the last decades. All X-ray and UV observations are consistent with a scenario in which an evolving Broad Absorption Line (BAL) flow obscures the continuum emission. As such, WPVS 007 is an important target for our understanding of BAL flows in low-mass active galactic nuclei (AGN).Comment: Accepted for publications in the Astronomical Journal; 29 pages, 10 Figures, 7 Table

Communications Biophysics

Contains reports on two research projects.United States Air Force (Contract AF19(604)-4112)United States National Institute of Neurological Diseases and Blindness, U.S. Public Health Service (BT-437)United States National Institute of Neurological Diseases and Blindness (B 369 Physiology)United States Navy, Office of Naval Research, (NR 101-445))United States Air Force, Office of Scientific Research (AF-49-(638)-98)