3,001 research outputs found
The importance of habitat quality for marine reserve fishery linkages
We model marine reserve - fishery linkages to evaluate the potential contribution of habitat-quality improvements inside a marine reserve to fish productivity and fishery catches. Data from Mombasa Marine National Park, Kenya, and the adjacent fishery are used. Marine reserves increase total fish biomass directly by providing refuge from exploitation and indirectly by improving fish habitat in the reserve. As natural mortality of the fish stock decreases in response to habitat enhancement in the reserve, catches increase by up to 2.6 tonnes (t).km(-2).year(-1) and total fish biomass by up to 36 t.km(-2). However, if habitat-quality improvement reduces the propensity of fish to move out of the reserve, catches may fall by up to 0.9 t.km(-2).year(-1). Our results indicate that habitat protection in reserves can underpin fish productivity and, depending on its effects on fish movements, augment catches
HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi's Sarcoma during AIDS.
Kaposi's sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer. KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected. In this study we tested if HIV evolutionary patterns distinguish KS tumor relatedness and progression. Multisite autopsies from participants who died from HIV-AIDS with KS prior to the availability of antiretroviral therapy were identified at the AIDS and Cancer Specimen Resource (ACSR). Two patients (KS1 and KS2) died predominantly from non-KS-associated disease and KS3 died due to aggressive and metastatic KS within one month of diagnosis. Skin and visceral tumor and nontumor autopsy tissues were obtained (n = 12). Single genome sequencing was used to amplify HIV RNA and DNA, which was present in all tumors. Independent HIV tumor clades in phylogenies differentiated KS1 and KS2 from KS3, whose sequences were interrelated by both phylogeny and selection. HIV compartmentalization was confirmed in KS1 and KS2 tumors; however, in KS3, no compartmentalization was observed among sampled tissues. While the sample size is small, the HIV evolutionary patterns observed in all patients suggest an interplay between tumor cells and HIV-infected cells which provides a selective advantage and could promote KS progression
Massive Increase, Spread, and Exchange of Extended Spectrum {beta}-Lactamase-Encoding Genes Among Intestinal Enterobacteriaceae in Hospitalized Children With Severe Acute Malnutrition in Niger.
Background. From the time of CTX-M emergence, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E) have spread worldwide in community settings as well as in hospitals, particularly in developing countries. Although their dissemination appears linked to Escherichia coli intestinal carriage, precise paths of this dynamic are largely unknown. Methods. Children from a pediatric renutrition center were prospectively enrolled in a fecal carriage study. Antibiotic exposure was recorded. ESBL-E strains were isolated using selective media from fecal samples obtained at admission and, when negative, also at discharge. ESBL-encoding genes were identified, their environments and plasmids were characterized, and clonality was assessed with polymerase chain reaction-based methods and pulsed-field gel electrophoresis for E. coli and Klebsiella pneumoniae. E. coli strains were subjected to multilocus sequence typing. Results. The ESBL-E carriage rate was 31% at admission in the 55 children enrolled. All children enrolled received antibiotics during hospitalization. Among the ESBL-E-negative children, 16 were resampled at discharge, and the acquisition rate was 94%. The bla(CTX-M-15) gene was found in >90% of the carriers. Genetic environments and plasmid characterization evidenced the roles of a worldwide, previously described, multidrug-resistant region and of IncF plasmids in CTX-M-15 E. coli dissemination. Diversity of CTX-M-15-carrying genetic structures and clonality of acquired ESBL E. coli suggested horizontal genetic transfer and underlined the potential of some ST types for nosocomial cross-transmission. Conclusions. Cross-transmission and high selective pressure lead to very high acquisition of ESBL-E carriage, contributing to dissemination in the community. Strict hygiene measures as well as careful balancing of benefit-risk ratio of current antibiotic policies need to be reevaluated
Confirmation of the \eps -- \eiso (Amati) relation from the X-ray flash XRF 050416A observed by Swift/BAT
We report Swift Burst Alert Telescope (BAT) observations of the X-ray Flash
(XRF) XRF 050416A. The fluence ratio between the 15-25 keV and 25-50 keV energy
bands of this event is 1.5, thus making it the softest gamma-ray burst (GRB)
observed by BAT so far. The spectrum is well fitted by the Band function with
E^{\rm obs}_{\rm peak} of 15.0_{-2.7}^{+2.3} keV. Assuming the redshift of the
host galaxy (z = 0.6535), the isotropic-equivalent radiated energy E_{\rm iso}
and the peak energy at the GRB rest frame (E^{\rm src}_{\rm peak}) of XRF
050416A are not only consistent with the correlation found by Amati et al. and
extended to XRFs by Sakamoto et al., but also fill-in the gap of this relation
around the 30 - 80 keV range of E^{\rm src}_{\rm peak}. This result tightens
the validity of the E^{\rm src}_{\rm peak} - E_{\rm iso} relation from XRFs to
GRBs.
We also find that the jet break time estimated using the empirical relation
between E^{\rm src}_{\rm peak} and the collimation corrected energy E_{\gamma}
is inconsistent with the afterglow observation by Swift X-ray Telescope. This
could be due to the extra external shock emission overlaid around the jet break
time or to the non existence of a jet break feature for XRF, which might be a
further challenging for GRB jet emission, models and XRF/GRB unification
scenarios.Comment: 16 pages, 4 figures; accepted for publication in ApJ
Co/Ni element ratio in the galactic cosmic rays between 0.8 and 4.3 GeV/nucleon
In a one-day balloon flight of the Trans-Iron Galactic Element Recorder (TIGER) in 1997, the instrument achieved excellent charge resolution for elements near the Fe peak, permitting a new measurement of the element ratio Co/Ni. The best fit to the data, extrapolated to the top of the atmosphere, gives an upper limit for this ratio of 0.093±0.037 over the energy interval 0.8 to 4.3 GeV/nucleon; because a Co peak is not seen in the data, this result is given as an upper limit. Comparing this upper limit with calculations by Webber & Gupta suggests that at the source of these cosmic rays a substantial amount of the electron-capture isotope 59Ni survived. This conclusion is in conflict with the clear evidence from ACE/CRIS below 0.5 GeV/nucleon that there is negligible 59Ni surviving at the source. Possible explanations for this apparent discrepancy are discussed
The phase diagram of the lattice Calogero-Sutherland model
We introduce a {\it lattice} version of the Calogero Sutherland model adapted
to describe pairwise interacting steps with discrete positions on a
vicinal surface. The configurational free energy is obtained within a transfer
matrix method. The full phase diagram for attractive and for repulsive
interaction is deduced. For attraction, critical temperatures of faceting
transitions are found to depend on step density.Comment: latex PRBCalogSuth.tex, 6 files, 4 pages [SPEC-S00/900
A measurement of cosmic ray deuterium from 0.5–2.9 GeV/nucleon
The rare isotopes ^(2)H and ^(3)He in cosmic rays are believed to originate mainly from the interaction of high energy protons and helium with the galactic interstellar medium. The unique propagation history of these rare isotopes provides important constraints on galactic cosmic ray source spectra and on models for their propagation within the Galaxy. Hydrogen and helium isotopes were measured with the balloon-borne experiment, IMAX, which flew from Lynn Lake, Manitoba in 1992. The energy spectrum of deuterium between 0.5 and 3.2 GeV/nucleon measured by the IMAX experiment as well as previously published results of ^(3)He from the same instrument will be compared with predictions of cosmic ray galactic propagation models. The observed composition of the light isotopes is found to be generally consistent with the predictions of the standard Leaky Box Model derived to fit observations of heavier nucle
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