Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011–2012 influenza season: A comparative effectiveness study using the Valencia health care information system

AbstractBackgroundThe use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.MethodsWe conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011–2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).ResultsOverall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50–0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52–0.85).ConclusionsDuring the 2011–2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV

Evaluation of landsat-8 thermal bands to monitor land surface temperature

Ponencia presentada en: IX Congreso de la Asociación Española de Climatología celebrado en Almería entre el 28 y el 30 de octubre de 2014.[ES]El nuevo Thermal Infrared Sensor (TIRS) a bordo del Landsat-8 (L8) dispone de dos bandas térmicas, 10 (11.60-11.19 μm) y 11 (11.50-12.51 μm), con una resolución espacial de 100m, con el fin de proporcionar temperaturas de la superficie terrestre (LST) de una manera más precisa que su predecesor Landsat-7 ETM+. El L8 fue lanzado en febrero de 2013, comenzando su adquisición operativa a mediados de abril. Los primeros estudios realizados por el equipo de calibración de L8 mostraron errores sistemáticos significativos para el TIRS, y en febrero de 2014 el archivo de imágenes L8 TIRS fue reprocesado para corregir dichos errores. En este estudio, con el fin de comprobar la calibración del L8 TIRS, realizamos medidas de campo en una zona llana y térmicamente homogénea dedicada al cultivo del arroz. A partir de estas medidas de LST simulamos las radiancias y temperaturas de brillo a nivel del satélite y las comparamos con los datos TIRS. Tal y como apuntaba el equipo de L8, nuestros resultados muestran una sobreestimación para la banda 11. Sin embargo, el recalibrado aplicado por dicho equipo para ambas bandas ha resultado no ser satisfactorio en nuestra zona experimental, ya que proponen sustraer errores sistemáticos mayores a los requeridos.[EN]The new Landsat-8 (L8) Thermal Infrared Sensor (TIRS) has two thermal bands, 10 (11.60- 11.19 μm) and 11 (11.50-12.51 μm) at 100-m spatial resolution, aimed to provide more accurate Land Surface Temperatures (LST) than Landsat-7 ETM+. L8 was launched on February 2013, and operational acquisitions started in middle April 2013. The first studies by the L8 Calibration Team showed significant TIRS temperature offsets, and in February 2014 the L8 TIRS archive was reprocessed to remove these offsets. In this study, ground LST measurements were performed in a flat and thermally homogeneous area of rice-crop fields for checking the calibration of the L8 TIRS bands. At-sensor radiances and brightness temperatures were simulated from ground-measured LSTs and compared with TIRS values. A significant overestimation was observed for band 11, in agreement with the L8 Calibration Team results. However, their recalibration was shown unsatisfactory in our test site for both bands, since they proposed subtracting higher offsets than required.This study was supported by the Spanish Ministerio de Economía y Competitividad (projects CGL2010-16364, CGL2010-17577/CLI, CGL2011-13579-E, CGL2011-30433 and GRACCIE Consolider-Ingenio 2010; and Dr. Niclòs "Ramón y Cajal" Research Contract) and Generalitat Valenciana (PROMETEO/2009/006 and PROMETEO/2009/086 projects)

LampLight Solutions 2008

Finalist

Un nuevo enfoque en el estudio de las interferencias

El efecto de las interferencias sobre los cóndilos, se estudia con la aportación del cálculo de estructuras mediante una investigación interdisciplinar. Con este estudio se intenta profundizar en el estudio objetivo de los efectos de las interferencias para una comparación con los hallazgos clinicos

Allocation mechanisms, incentives, and endemic institutional externalities

Whether an economic agent’s decision creates an externality often depends on the institutional context in which the decision was made. Indeed, in orthodox economics, a technological or exogenous externality occurs just in case one agent’s economic welfare or production possibilities are directly affected by the market decisions of other agents. A pecuniary externality occurs just in case one consumer’s economic welfare or producer’s profit is affected indirectly by price changes caused by changes in other agents’ decisions. Similarly, an institutional or endogenous externality may arise whenever allocations are determined by a mechanism that is not strategy proof for some agent. Then even a resource balance constraint creates an institutional externality except in special cases such as when no individual agent’s action can affect market clearing prices — i.e., there are no pecuniary externalities

Characterizing Vickrey allocation rule by anonymity

We consider the problem of allocating finitely many units of an indivisible good among a group of agents when each agent receives at most one unit of the good and pays a non-negative price. For example, imagine that a government allocates a fixed number of licenses to private firms, or that it distributes equally divided lands to households. Anonymity in welfare is a condition of impartiality in the sense that it requires allocation rules to treat agents equally in welfare terms from the viewpoint of agents who are ignorant of their own valuations or identities. We show that the Vickrey allocation rule is the unique allocation rule satisfying strategy-proofness, anonymity in welfare, and individual rationality

Quality-of-Life Impact of an Investigational Subunit-Adjuvanted Herpes Zoster Vaccine in Adults ≥50 Years of Age

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