Delayed eruption of permanent dentition and maxillary contraction in patients with cleidocranial dysplasia: review and report of a family

Introduction. Cleidocranial dysplasia (CCD) is an inherited disease caused by mutations in the RUNX2 gene on chromosome 6p21. This pathology, autosomal dominant or caused by a spontaneous genetic mutation, is present in one in one million individuals, with complete penetrance and widely variable expressivity. Aim. To identify the incidence of these clinical findings in the report of the literature by means of PubMed interface from 2002 to 2015, with the related keywords. The report of local patients presents a clinical example, related to the therapeutic approach. Results and Discussions. The PubMed research resulted in 122 articles. All the typical signs were reported in all presented cases. The maxilla was hypoplastic in 94% of the patients. Missing of permanent teeth was found in two cases: one case presented a class II jaw relationship, instead of class III malocclusion. Similar findings were present in our cohort. Conclusion. CCD is challenging for both the dental team and the patient. The treatment requires a multidisciplinary approach. Further studies are required to better understand the cause of this disease. According to this review, a multistep approach enhances the possibilities to achieve the recovery of the most possible number of teeth, as such to obtain a good occlusion and a better aesthetic

Full Characterization of the First 1 Inch Industrial Prototype of a New Concept Photodetector

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an original design for an innovative light detector we proposed with the aim to create new scientific instrumentation for industrial applications and physics research. The idea behind this device is to replace the classical dynode chain of a photomultiplier tube with a silicon photomultiplier, the latter acting as an electron detector and amplifier. The VSiPMT offers very attractive features and unprecedented performance, definitely superior to every other photodetector with comparable sensitive surface, such as: negligible power cosumption, excellent photon counting, easy low-voltage-based stabilization and very good time performance. After the feasibility test of the idea, Hamamatsu Photonics realized for our research group two VSiPMT industrial prototypes, that have been fully characterized. The results of the full characterization of the 1-inch industrial prototype are presented in this work.Comment: 11 pages, 14 figure

Fate and Characteristics of Dissolved Organic Nitrogen through Wastewater Treatment Systems

Dissolved organic nitrogen (DON) represents a significant portion (25-80%) of total dissolved nitrogen in the final effluent of wastewater treatment plants (WWTPs). DON in treated wastewater, once degraded, causes oxygen depletion and/or eutrophication in receiving waters and should be reduced prior to discharge. Biodegradability, bioavailability, and photodegradability are important characteristics of wastewater derived DON and are subjects of research in this dissertation. Four research tasks were performed. In the first task, laboratory-scale chemostat experiments were conducted to examine whether solids retention time (SRT) could be used to control DON and biodegradable DON (BDON) in treated wastewater. Nine different SRTs from 0.3 to 13 were studied. There was no correlation between effluent DON and SRTs. However, BDONs at SRTs of 0.3 to 4 days were comparable and had a decreasing trend with SRTs after that. These results indicate the benefit of high SRTs in term of producing effluent with less BDON. The second task was a comprehensive year-round data collection to study the fate of DON and BDON through the treatment train of a trickling filter (TF) WWTP. The plant removed substantial amounts of DON (62%) and BDON (76%) mainly through the biological process. However, the discharged concentrations in the effluent were still high enough to be critical for a stringent total nitrogen discharge limit (below 5 mg-N/L). Evolution of bioavailable DON (ABDON) along the treatment trains of activated sludge (AS) and TF WWTPs and relationship between ABDON and BDON were examined in the third task. ABDON exerted from a combination of bacteria and algae inocula was higher than algae inoculated ABDON and bacteria inoculated BDON suggesting the use of algae as a treatment organism along with bacteria to minimize effluent DON. The TF and AS WWTPs removed 88% and 64% of ABDON, respectively. In the last task, photodegradable DON (PDON) in primary wastewater and final effluent from TF and AS WWTPs was studied. PDON and BDON fractions of DON data in the final effluent of TF and AS WWTP samples elucidate that photodegradation is as critically important as biodegradation when mineralization of effluent DON is a concern in receiving waters

A privacy-friendly game-theoretic distributed scheduling system for domestic appliances

open3Game-theoretic Demand Side Management (DSM) systems have been investigated as a decentralized approach for the collaborative scheduling of the usage of domestic electrical appliances within a set of households. Such systems allow for the shifting of the starting time of deferrable devices according to the current energy price or power grid condition, in order to reduce the individual monthly bill or to adjust the power load experienced by the grid while meeting the users’ preferences about the time of use. The drawback of DSM distributed protocols is that they require each user to communicate his/her own energy consumption patterns to the other users, which may leak sensitive information regarding private habits. This paper proposes a distributed Privacy-Friendly DSM system which preserves users’ privacy by integrating data aggregation and perturbation techniques: users decide their schedule according to aggregated consumption measurements perturbed by means of Additive White Gaussian Noise (AWGN). We evaluate the noise power and the size of the set of users required to achieve a given privacy level, quantified by means of the Kullback-Leibler divergence. The performance of our proposed DSM system are compared to the ones obtained by a benchmark system which does not support privacy preservation in terms of social cost, peak demand and convergence time. Results show that privacy can be preserved at the cost of increasing the peak demand and the number of game iterations, whereas social cost is only marginally incremented.C Rottondi; A Barbato; G VerticaleRottondi, CRISTINA EMMA MARGHERITA; Barbato, Antimo; Verticale, Giacom

The role of the organisational dimension in university positioning: a case-study approach

This paper argues that university strategic positioning is influenced by the organisational dimension, operationalised along the variables of organisational structure, identity and centrality. A comparative case study is presented including two English and two Italian universities and drawing on a set of sixty interviews with academic leaders, managers and administrators. The analysis of the trajectory of the four universities from 2004 to 2018 illustrates the articulation of the link between the three organisational variables and positioning and how this has changed over time. Finally, the paper outlines six propositions on the expected impact of the organisational structure, identity and centrality on positioning processes of universities

The determinants of university strategic positioning: a reappraisal of the organisation

This paper makes a contribution to the debate on university organisational actorhood by theorising the determinants of institutional strategic positioning. It argues that besides environmental forces and managerial rationality, the organisational dimension needs to be accounted for. Addressing the mixed empirical evidence in the relevant literature, we conceptualise the organisational dimension as a meso-level intervening variable mediating both external influences (outside-inside) and organisational action (inside-outside). We operationalise the organisational dimension along three components: organisational structure, identity and centrality, which are further elaborated in sub-components and indicators. A set of hypotheses to be tested in empirical research is provided. The paper offers new perspectives on the dynamics of change in higher education and on strategic agency of organisational actors

The determinants of university strategic positioning: A reappraisal of the organizational dimension

This paper makes a contribution to the debate on university organisational actorhood by theorising the determinants of institutional strategic positioning. It argues that besides environmental forces and managerial rationality, the organisational dimension needs to be accounted for. Addressing the mixed empirical evidence in the relevant literature, we conceptualise the organisational dimension as a meso-level intervening variable mediating both external influences (outside-inside) and organisational action (inside-outside). We operationalize the organizational dimension along three components: organizational structure, identity, and centrality, which are further elaborated in sub-components and indicators. A set of hypotheses to be tested in empirical research is provided. The paper offers new perspectives on the dynamics of change in higher education and on strategic agency of organizational actors

Clear aligners: between evolution and efficiency—a scoping review

In recent years, clear aligners have diversified and evolved in their primary characteristics (material, gingival margin design, attachments, divots, auxiliaries), increasing their indications and efficiency. We overviewed the brands of aligners used in Italy and reviewed the literature on the evolution of clear aligners based on their characteristics mentioned above by consulting the main scientific databases (PubMed, Scopus, Lilacs, Google Scholar, Cochrane Library). Inclusion and ex-clusion criteria were established. The data were collected on a purpose-made data collection form and analyzed descriptively. From the initial 580 records, 527 were excluded because they were not related to the subject of the review or because they did not meet the eligibility criteria. The remaining 31 studies were deemed comprehensive for the purpose of the review, although the “gingival margin design” feature and “auxiliaries” tool are not well represented in the more recent literature. Current knowledge on invisible aligners allows us to have a much clearer idea of the basic characteristics of aligner systems. There remains a need to deepen the use of systems other than In-visalign™ to give greater evidence to aligners that are very different based on the characteristics analyzed here and that are very widespread on the market

Recognition mechanism of p63 by the E3 ligase Itch Novel strategy in the study and inhibition of this interaction.

The HECT-containing E3 ubiquitin ligase Itch mediates the degradation of several proteins, including p63 and p73, involved in cell specification and fate. Itch contains four WW domains, which are essential for recognition on the target substrate, which contains a short proline-rich sequence. Several signaling complexes containing these domains have been associated with human diseases such as muscular dystrophy, Alzheimer’s or Huntington’s diseases. To gain further insight into the structural determinants of the Itch-WW2 domain, we investigated its interaction with p63. We assigned, by 3D heteronuclear NMR experiments, the backbone and side chains of the uniformly 13C-15N-labeled Itch-WW2. In vitro interaction of Itch-WW2 domain with p63 was studied using its interactive p63 peptide, pep63. Pep63 is an 18-mer peptide corresponding to the region from 534–551 residue of p63, encompassing the PP xY motif that interacts with the Itch-WW domains, and we identified the residues involved in this molecular recognition. Moreover, here, a strategy of stabilization of the conformation of the PP xY peptide has been adopted, increasing the WW-ligand binding. We demonstrated that cyclization of pep63 leads to an increase of both the biological stability of the peptide and of the WW-ligand complex. Stable metal-binding complexes of the pep63 have been also obtained, and localized oxidative damage on Itch-WW2 domain has been induced, demonstrating the possibility of use of metal-pep63 complexes as models for the design of metal drugs to inhibit the Itch-WW-p63 recognition in vivo. Thus, our data suggest a novel strategy to study and inhibit the recognition mechanism of Itch E3-ligase