Clinical and radiological criteria for the differential diagnosis between asbestosis and idiopathic pulmonary fibrosis: Application in two cases

Introduction: Idiopathic pulmonary fibrosis (IPF) and asbestosis are pulmonary interstitial diseases that may present overlapping clinical aspects in the full-blown phase of the disease. For both clinical entities the gold standard for diagnosis is histological examination, but its execution poses ethical problems, especially when performed for preventive or forensic purposes. Objective: To evaluate the application of internationally accepted clinical, anamnestic and radiological criteria for differential diagnosis between asbestosis and IPF, and to assess the ability to discriminate between the two diseases. Even if clinically similar, the two diseases present extremely different prognostic and therapeutic perspectives. Methods: Two clinical cases of IPF are reported, in which the differential diagnosis was made by studying occupational exposure to asbestos, the onset and progression of clinical symptoms, and the identification of specific radiological elements by means of chest High Resolution Computed Tomography (HRCT). Results: The diagnosis of IPF could be made on the basis of the absence of significant exposure to asbestos, the early onset and rapid progression of dyspnea and restrictive ventilatory defects, in association with a pulmonary radiological pattern characterized by peculiar elements such as honeycombing. Discussion: The diagnostic procedure adopted to make a differential diagnosis with asbestosis provides practical clinical elements facilitating the differentiation between the two forms of pulmonary fibrosis, a fundamental aspect of the activity of the occupational physician

The mechanics of the lung parenchyma and airway responsiveness to metacholine.

The lung parenchyma is anatomically and mechanically connected to the intraparenchymal airways. Due to forces of interdependence the lung parenchyma represents a mechanical load that opposes bronchial narrowing during airway smooth muscle activation. The mechanical load caused by the parenchyma is a function of the number of the alveolar attachments to the airways, and of the mechanical properties of the parenchyma. The extracellular matrix is a major component of the lung parenchyma responsible of most of its mechanical properties. The excessive airway narrowing observed in the asthmatic population may be the consequence of the altered mechanical properties of the extracellular matrix reducing the mechanical load that opposes airway smooth muscle contraction

Wearable System Based on Ultra-Thin Parylene C Tattoo Electrodes for EEG Recording

In an increasingly interconnected world, where electronic devices permeate every aspect of our lives, wearable systems aimed at monitoring physiological signals are rapidly taking over the sport and fitness domain, as well as biomedical fields such as rehabilitation and prosthetics. With the intent of providing a novel approach to the field, in this paper we discuss the development of a wearable system for the acquisition of EEG signals based on a portable, low-power custom PCB specifically designed to be used in combination with non-conventional ultra-conformable and imperceptible Parylene-C tattoo electrodes. The proposed system has been tested in a standard rest-state experiment, and its performance in terms of discrimination of two different states has been compared to that of a commercial wearable device for EEG signal acquisition (i.e., the Muse headset), showing comparable results. This first preliminary validation demonstrates the possibility of conveniently employing ultra-conformable tattoo-electrodes integrated portable systems for the unobtrusive acquisition of brain activity

Production of high purity 52g^{52g}Mn from nat^{nat}V targets with α\alpha-beams at cyclotrons

Radioisotope $^{52g}$Mn is of special interest for multimodal imaging. Using state-of-art nuclear reaction codes, we study the alternative nuclear reaction route $^{nat}$V($\alpha$,x)$^{52g}$Mn in comparison with the standard production routes based upon the use of chromium targets. The integral yields of $^{52g}$Mn and contaminants have been evaluated. The main outcome of this investigation is that the production of the main contaminant isotope $^{54}$Mn is expected to be lower than with $^{nat}$Cr. The study also reveals a large spread in the cross-section data set and points out the need of more precise measurements of the reaction $^{nat}$V($\alpha$,x)$^{52g}$Mn as well as the need of a more accurate theoretical description.Comment: Keywords: Cyclotron radionuclide production, $^{52g}$Mn, $^{53}$Mn, $^{54}$Mn, multi-modal imaging,{\alpha}-induced reactions, nuclear reactions modelin

Constraints on a Universal IMF from UV to Near-IR Galaxy Luminosity Densities

We obtain constraints on the slope of a universal stellar initial mass function (IMF) over a range of cosmic star-formation histories (SFH) using z=0.1 luminosity densities in the range from 0.2 to 2.2 microns. The age-IMF degeneracy of integrated spectra of stellar populations can be broken for the Universe as a whole by using direct measurements of (relative) cosmic SFH from high-redshift observations. These have only marginal dependence on uncertainties in the IMF, whereas, fitting to local luminosity densities depends strongly on both cosmic SFH and the IMF. We fit to these measurements using population synthesis and find the best-fit IMF power-law slope to be Gamma=1.15+-0.2 (0.5 < M/M_solar < 120). This slope is in good agreement with the Salpeter IMF slope (Gamma=1.35). A strong upper limit of Gamma<1.7 is obtained which effectively rules out the Scalo IMF due to its too low fraction of high-mass stars. This upper limit is at the 99.7% confidence level if we assume a closed-box chemical evolution scenario and 95% if we assume constant solar metallicity. Fitting to the H-alpha line luminosity density, we obtain a best-fit IMF slope in good agreement with that derived from broadband measurements. Marginalizing over cosmic SFH and IMF slope, we obtain (95% conf. ranges, h=1): omega_stars = 1.1-2.0 E-3 for the stellar mass density; rho_sfr = 0.7-4.1 E-2 M_solar/yr/Mpc^3 for the star-formation rate density, and; rho_L = 1.2-1.7 E+35 W/Mpc^3 for the bolometric, attenuated, stellar, luminosity density (0.09-5 microns). Comparing this total stellar emission with an estimate of the total dust emission implies a relatively modest average attenuation in the UV (<=1 magnitude at 0.2 microns).Comment: 16 pages, accepted by Ap

Optical Spectral Signatures of Dusty Starburst Galaxies

We analyse the optical spectral properties of the complete sample of Very Luminous Infrared Galaxies presented by Wu et al. (1998a,b) and we find a high fraction (~50 %) of spectra showing both a strong H_delta line in absorption and relatively modest [OII] emission (e(a) spectra). The e(a) signature has been proposed as an efficient method to identify dusty starburst galaxies and we study the star formation activity and the nature of these galaxies, as well as the effects of dust on their observed properties. We examine their emission line characteristics, in particular their [OII]/H_alpha ratio, and we find this to be greatly affected by reddening. A search for AGN spectral signatures reveals that the e(a)'s are typically HII/LINER galaxies. We compare the star formation rates derived from the FIR luminosities with the estimates based on the H_alpha line and find that the values obtained from the optical emission lines are a factor of 10-70 (H_alpha) and 20-140 ([OII]) lower than the FIR estimates (50-300 M_sun yr^-1). We then study the morphological properties of the e(a) galaxies, looking for a near companion or signs of a merger/interaction. In order to explore the evolution of the e(a) population, we present an overview of the available observations of e(a)'s in different environments both at low and high redshift. Finally, we discuss the role of dust in determining the e(a) spectral properties and we propose a scenario of selective obscuration in which the extinction decreases with the stellar age.Comment: 26 pages, Latex, including 7 postscript figures, accepted for publication in the Astrophysical Journa

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis.

Abstract BACKGROUND AND AIM: Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome. The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. METHODS: Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. RESULTS: Concentrations of oral and nasal exhaled IL-6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p < 0.001) and IL-4 (p < 0.05) was observed after polypectomy. CONCLUSIONS: We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis