Digital Twins of Organizations: A Socio-Technical View on Challenges and Opportunities for Future Research

Digital twins of organizations are software models that leverage operational and other data streams in order to dynamically monitor, analyze and improve organizational activities over time. Despite surging interest in practice, there is little research about this emerging topic. In this report, we draw from a panel discussion that has taken place at the International Conference on Business Process Management in 2021. Panelists and discussants included scholars from the information systems field, organization science and computer science. Summarizing and integrating the variety of involved perspectives, we present a socio-technical view on this emerging phenomenon. We point to several implications for future research

Search for modulations of the solar Be-7 flux in the next-generation neutrino observatory LENA

A next-generation liquid-scintillator detector will be able to perform high-statistics measurements of the solar neutrino flux. In LENA, solar Be-7 neutrinos are expected to cause 1.7x10^4 electron recoil events per day in a fiducial volume of 35 kilotons. Based on this signal, a search for periodic modulations on sub-percent level can be conducted, surpassing the sensitivity of current detectors by at least a factor of 20. The range of accessible periods reaches from several minutes, corresponding to modulations induced by helioseismic g-modes, to tens of years, allowing to study long-term changes in solar fusion rates.Comment: 15 pages, 9 figure

Day care study showed no differences in long-term symptoms in children who were and were not infected during COVID-19 outbreaks

Peer Reviewe

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Targeted protein degradation offers an alternative modality to classical inhibition and holds the promise of addressing previously undruggable targets to provide novel therapeutic options for patients. Heterobifunctional molecules co-recruit a target protein and an E3 ligase, resulting in ubiquitylation and proteosome-dependent degradation of the target. In the clinic, the oral route of administration is the option of choice but has only been achieved so far by CRBN- recruiting bifunctional degrader molecules. We aimed to achieve orally bioavailable molecules that selectively degrade the BAF Chromatin Remodelling complex ATPase SMARCA2 over its closely related paralogue SMARCA4, to allow in vivo evaluation of the synthetic lethality concept of SMARCA2 dependency in SMARCA4-deficient cancers. Here we outline structure- and property-guided approaches that led to orally bioavailable VHL-recruiting degraders. Our tool compound, ACBI2, shows selective degradation of SMARCA2 over SMARCA4 in ex vivo human whole blood assays and in vivo efficacy in SMARCA4-deficient cancer models. This study demonstrates the feasibility for broadening the E3 ligase and physicochemical space that can be utilised for achieving oral efficacy with bifunctional molecules

Formal approaches to number in Slavic and beyond

The goal of this collective monograph is to explore the relationship between the cognitive notion of number and various grammatical devices expressing this concept in natural language with a special focus on Slavic. The book aims at investigating different morphosyntactic and semantic categories including plurality and number-marking, individuation and countability, cumulativity, distributivity and collectivity, numerals, numeral modifiers and classifiers, as well as other quantifiers. It gathers 19 contributions tackling the main themes from different theoretical and methodological perspectives in order to contribute to our understanding of cross-linguistic patterns both in Slavic and non-Slavic languages

Formal approaches to number in Slavic and beyond

The goal of this collective monograph is to explore the relationship between the cognitive notion of number and various grammatical devices expressing this concept in natural language with a special focus on Slavic. The book aims at investigating different morphosyntactic and semantic categories including plurality and number-marking, individuation and countability, cumulativity, distributivity and collectivity, numerals, numeral modifiers and classifiers, as well as other quantifiers. It gathers 19 contributions tackling the main themes from different theoretical and methodological perspectives in order to contribute to our understanding of cross-linguistic patterns both in Slavic and non-Slavic languages

Formal approaches to number in Slavic and beyond

The goal of this collective monograph is to explore the relationship between the cognitive notion of number and various grammatical devices expressing this concept in natural language with a special focus on Slavic. The book aims at investigating different morphosyntactic and semantic categories including plurality and number-marking, individuation and countability, cumulativity, distributivity and collectivity, numerals, numeral modifiers and classifiers, as well as other quantifiers. It gathers 19 contributions tackling the main themes from different theoretical and methodological perspectives in order to contribute to our understanding of cross-linguistic patterns both in Slavic and non-Slavic languages

Formal approaches to number in Slavic and beyond

The goal of this collective monograph is to explore the relationship between the cognitive notion of number and various grammatical devices expressing this concept in natural language with a special focus on Slavic. The book aims at investigating different morphosyntactic and semantic categories including plurality and number-marking, individuation and countability, cumulativity, distributivity and collectivity, numerals, numeral modifiers and classifiers, as well as other quantifiers. It gathers 19 contributions tackling the main themes from different theoretical and methodological perspectives in order to contribute to our understanding of cross-linguistic patterns both in Slavic and non-Slavic languages