The Neonatal Microbiome and Necrotizing Enterocolitis.

Necrotizing enterocolitis (NEC) is a devastating disorder that affects approximately 10% of premature infants. Its mortality remains high (15-30%), and its cause remains unknown. About 80% of cases occur within 35 days of birth among hospitalized newborns of low birth weight. Probiotics diminish the incidence and severity of NEC, and NEC does not occur antepartum. NEC affects a readily identifiable at-risk group, has a tightly defined interval before its onset, occurs in an organ system that is intimately associated with a microbial population in flux, has a plausible association with the intestinal microbiota, and cohorts at risk have rarely been studied in large numbers, or prospectively. This disorder, therefore, provides a unique opportunity to explore the role of the human enteric microbiome in a devastating disease. Moreover, NEC epidemiology and age-incidence present an ability to enroll and study cohorts that are highly likely to provide valuable pathophysiologic and microbiologic insights.

In this project, we will identify and quantify the microbial components of stool and its products before and at the onset of NEC. In doing so, we will test the overarching hypothesis that NEC is a direct or indirect consequence of the enteric biomass, its products, or both. We will use multicenter cohorts of premature infants at high risk of developing NEC, extend our research on this disease currently sponsored by the Washington University Institute of Clinical and Translational Sciences, and continue our longstanding collaborations with the Genome Center at Washington University and the Washington University Digestive Diseases Research Core Center (Informatics Core). The Aims of this proposal are to (1) conduct a case cohort study in which we compare clinical data and biological specimens from cases and well-matched controls; (2) determine if the kind and density of intestinal biomass, its gene content, and transcriptional activity are associated with, and potential determinants of, NEC; and (3) determine if host risk alleles for intestinal inflammation play a role in the development of NEC. These efforts will be accomplished using subjects from three collaborating neonatal intensive care units (NICUs), focusing on the critical, instructive, and understudied pre-NEC stage of illness, and formulating a data repository that will be a resource for investigators worldwide who wish to focus their efforts on NEC, its precipitants, and its prevention and cure.
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L'art de le dire. Une réflexion méthodologique sur les histoires de djinns et autres sujets

Paru en janvier 2007.http://vbat.org Article de Barbara Drieskens, traduit de l'anglais par Vincent BattestiInternational audienceArticle de Barbara Drieskens, traduit de l'anglais par Vincent Battesti. Au Caire raconter une histoire est un art qui implique à la fois les auditeurs et le narrateur. Il serait faux de distinguer entre un narrateur actif et un récepteur passif. Le public et le narrateur participent tous deux à l'événement de narration. Ensemble, ils constituent le sujet, le contexte opportun, la forme de l'histoire et les émotions en jeu. Les histoires naissent d'une rencontre, elles sont adaptées à un contexte, à des participants, à un lieu et un moment. Dans cette contribution, je montrerai comment tous ces éléments sont en corrélation et pourquoi tous ces éléments doivent être pris en compte pour saisir la richesse, les multiples messages et le sens d'une histoire sur les djinns ou sur d'autres sujets

Almost sharp sharpness for Poisson Boolean percolation

We consider Poisson Boolean percolation on $\mathbb R^d$ with power-law distribution on the radius with a finite $d$-moment for $d\ge 2$. We prove that subcritical sharpness occurs for all but a countable number of power-law distributions. This extends the results of Duminil-Copin--Raoufi--Tassion where subcritical sharpness is proved under the assumption that the radii distribution has a $5d-3$ finite moment. Our proofs techniques are different from their paper: we do not use randomized algorithm and rely on specific independence properties of Boolean percolation, inherited from the underlying Poisson process. We also prove supercritical sharpness for any distribution with a finite $d$-moment and the continuity of the critical parameter for the truncated distribution when the truncation goes to infinity

Modeling the Offshore Export of Subantarctic Shelf Waters From the Patagonian Shelf

It has been suggested that the Subtropical Shelf Front (STSF) could be a preferential site for the detrainment of Subantarctic Shelf Water (SASW) and related planktonic shelf species onto the open SW Atlantic Ocean. The offshore detrainment of SASW and planktonic shelf species might be an exportation mechanism, affecting the population abundances of fishing resources in Argentina, Uruguay, and Southern Brazil. In this study, we characterize for the first time the 3-D structure of the STSF and the main routes of offshore export of SASW from the Patagonian shelf during austral summer (summer and early fall) and winter (winter and early spring) by using numerical hydrodynamical model results and Lagrangian tracking simulations of neutrally buoyant floats. The transport of SASW toward the open ocean is ~1 Sv (1 Sv = 106 m3/s) during summer and ~0.8 Sv during winter. SASW are exported offshore mainly near the Brazil-Malvinas Confluence region during both seasons. The STSF appears to act as an important retention mechanism for the plankton over the inner and middle shelf mainly during late summer and early fall. Our findings could explain the life cycle of distinct fish species that are distributed in the region, as well as the population abundance variability of such species.Fil: Franco, Barbara Cristie. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; ArgentinaFil: Palma, Elbio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: Combes, Vincent. State University of Oregon; Estados UnidosFil: Acha, Eduardo Marcelo. Instituto Nacional de Investigaciones y Desarrollo Pesquero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Saraceno, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; Argentin

Incorporating a generalised additive model of river nutrient concentrations into a mechanistic receiving water model

eReefs is a large, collaborative project that is building catchment and marine models for Australia's Great Barrier Reef Lagoon (GBRL), a world-heritage environmental asset. The eReefs package includes three-dimensional mechanistic biogeochemical, sediment and hydrodynamic models for the entire GBRL on 4 km and 1 km grid scales, along with a relocatable coastal and estuary model (RECOM) that can be nested within the larger-scale models. Source Catchment models developed by the Government of Queensland for each GBRL catchment will be used to run scenarios to predict the effects of management and land use changes on nitrogen, phosphorus and sediment loads reaching each river. For day-to-day near-real-time and forecast-mode running of the marine models, however, another approach is needed to provide the river loads of sediments, dissolved and particulate loads required as boundary conditions. Generalised Additive Models (GAMs) have been shown (e. g. Kuhnert et al., 2012) to be powerful tools for the prediction of suspended sediment and particulate nutrient loads in tropical rivers. Here, we extend previous work to build GAMs that are able to predict concentrations of suspended sediments, dissolved and particulate nutrients in the Fitzroy River (Queensland) on a daily time-step. In developing the GAMs, we tested a number of routinely and frequently measured meteorological and hydrological variables for potential predictive power. The new terms considered included water temperature (which may alter biogeochemical processing rates), air temperature (a more reliably measured proxy for water temperature), electrical conductivity (which may reflect the influence of particular subcatchment sources), barometric pressure (an indicator of local storm activity), wind stress (which may affect resuspension and mixing in the river and its weirs) and flow from river tributaries (a direct measure of the influence of particular subcatchments). The models generated were tested with regard to the validity of key statistical assumptions, and were then validated against a subset of observational data that had been held back from the original calibration. The strongest models included flow in the Fitzroy River, flow in one or more tributaries, and a discounted flow term that reflected flow in the preceding days and weeks. Models that did not include tributary flow were able to predict concentrations of particulate, but not dissolved materials. Neither meteorological terms nor electrical conductivity proved to be useful predictors, while water temperature was of marginal value. The final GAM provide more accurate predictions on a daily time-step than previously available methods, for both dissolved and particulate materials, and is being used to provide time-series input (e. g. Figure 1) to mechanistic marine models

Pre-College Factors Influencing College Students’ Civic Attitudes: The Importance of Familial and Community Service Experiences

Entering university students (N = 178) were surveyed in the fall of 2013 to learn about their attitudes toward college and civic engagement.  As with students beginning study at the same university five to seven years earlier, participants felt positive about the institution’s public service graduation requirement and indicated plans to engage in substantial service during college.  Their civic attitudes were as or slightly more positive than those of students surveyed earlier, but they were less positive in their self-reported knowledge of the community.  Students’ reports of family orientation toward community service predicted their views of the graduation requirement, as well as their civic attitudes (i.e., civic responsibility, value placed on community service, and social justice).  Replicating earlier research, students’ pre-college community service, especially their reported enjoyment of service activities, predicted attitudes toward the graduation requirement and civic attitudes.  A mediation model showed that the effects of family orientation on civic attitudes were partially mediated by students’ involvement in service during secondary school years.  The authors discuss the implications of these findings for K-12 and college programming

Novel Distances for Dollo Data

We investigate distances on binary (presence/absence) data in the context of a Dollo process, where a trait can only arise once on a phylogenetic tree but may be lost many times. We introduce a novel distance, the Additive Dollo Distance (ADD), which is consistent for data generated under a Dollo model, and show that it has some useful theoretical properties including an intriguing link to the LogDet distance. Simulations of Dollo data are used to compare a number of binary distances including ADD, LogDet, Nei Li and some simple, but to our knowledge previously unstudied, variations on common binary distances. The simulations suggest that ADD outperforms other distances on Dollo data. Interestingly, we found that the LogDet distance performs poorly in the context of a Dollo process, which may have implications for its use in connection with conditioned genome reconstruction. We apply the ADD to two Diversity Arrays Technology (DArT) datasets, one that broadly covers Eucalyptus species and one that focuses on the Eucalyptus series Adnataria. We also reanalyse gene family presence/absence data on bacteria from the COG database and compare the results to previous phylogenies estimated using the conditioned genome reconstruction approach

Soliton interactions and Yang-Baxter maps for the complex coupled short-pulse equation

The complex coupled short pulse equation (ccSPE) describes the propagation of ultra-short optical pulses in nonlinear birefringent fibers. The system admits a variety of vector soliton solutions: fundamental solitons, fundamental breathers, composite breathers (generic or non-generic), as well as so-called self-symmetric composite solitons. In this work, we use the dressing method and the Darboux matrices corresponding to the various types of solitons to investigate soliton interactions in the focusing ccSPE. The study combines refactorization problems on generators of certain rational loop groups, and long-time asymptotics of these generators, as well as the main refactorization theorem for the dressing factors which leads to the Yang-Baxter property for the refactorization map and the vector soliton interactions. Among the results obtained in this paper, we derive explicit formulas for the polarization shift of fundamental solitons which are the analog of the well-known formulas for the interaction of vector solitons in the Manakov system. Our study also reveals that upon interacting with a fundamental breather, a fundamental soliton becomes a fundamental breather and, conversely, that the interaction of two fundamental breathers generically yields two fundamental breathers with a polarization shifts, but may also result into a fundamental soliton and a fundamental breather. Explicit formulas for the coefficients that characterize the fundamental breathers, as well as for their polarization vectors are obtained. The interactions of other types of solitons are also derived and discussed in detail and illustrated with plots. New Yang-Baxter maps are obtained in the process.Comment: 62 pages (40 + 22 pages of appendices), 5 figures. Authors' accepted version in SAP

The Hot R Coronae Borealis Star DY Centauri is a Binary

The remarkable hot R Coronae Borealis (RCB) star DY Cen is revealed to be the first and only binary system to be found among the RCB stars and their likely relatives, including the extreme helium stars and the hydrogen-deficient carbon stars. Radial velocity determinations from 1982 to 2010 have shown that DY Cen is a single-lined spectroscopic binary in an eccentric orbit with a period of 39.67 days. It is also one of the hottest and most H-rich member of the class of RCB stars. The system may have evolved from a common envelope to its current form.Spanish Ministry of Economy and Competitiveness AYA-2011-27754McDonald Observator