Balls, Barbecues and Boxing : Contesting gender regimes at organizational social events

What do the relaxed social events held by companies and organizations do for continued gender inequality? This article argues that outings, barbecues and parties offer opportunities for members of an organization to challenge unequal gender regimes. But they can also end up maintaining these inequalities instead. The article draws on Joan Acker’s theory of gendered organizations, and Judith Butler’s notion of gender performativity. Based on 208 accounts of organizations’ social events, it identifies the following four areas of gender performativity and their varying significance in reaffirming or challenging unequal gender regimes: gender images, status differences, the body and sexuality. The findings indicate that practices reaffirming unequal gender regimes outnumber practices that possibly balance or break them. Paradoxically, practices that challenge unequal gender regimes, when joined with powerful responses from the hitherto privileged party, can form a vicious circle which again ends up continuing unequal gender regimes. The article provides a more nuanced understanding of ambivalences and the contested nature of gender regimes which is important in identifying avenues for gender equality

Funktionen und Wirkungen von Betriebsfeiern: eine Analyse am Beispiel von Die Firma und Die Blume der Hausfrau

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Wissenschaft-Praxis-Projekte als kleinformatige und individualisierte Weiterbildungsangebote

Die Hybridstellung wissenschaftlicher Weiterbildung zwischen Hochschul- und Berufsbildungsforschung ermöglicht, Bezüge beider Bildungswelten aufzugreifen. Dabei gilt es, Forschungsorientierung und Anwendungsbezug gleichermaßen in kompetenzorientierte und individualisierte Studienangebote zu integrieren. Dieser Werkstattbericht fokussiert die Verknüpfung theoretischer Bezüge mit Erfahrungen in der operativen Formatentwicklung von Wissenschaft-Praxis-Projekten im Projekt ContinuING@TUHH

Assessment of Diagnostic Strategy for Mucous Membrane Pemphigoid

IMPORTANCE: An accurate diagnosis of mucous membrane pemphigoid (MMP) is essential to reduce diagnostic and therapeutic delay. OBJECTIVE: To assess the diagnostic accuracy of direct immunofluorescence microscopy on mucosal biopsy specimens and immunoserology in a large cohort of patients with suspected MMP. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was carried out in a single tertiary care center for blistering diseases between January 2002 and March 2019. Eligible participants were patients with suspected MMP and paired data on at least a mucosal biopsy specimen for direct immunofluorescence microscopy (DIF) and indirect immunofluorescence microscopy (IIF) on a human salt-split skin substrate (SSS). In addition, an optional DIF test on a skin biopsy specimen and one or more performed routine immunoserologic tests were analyzed. Data analysis was conducted from April 2019, to June 2020. MAIN OUTCOMES AND MEASURES: Diagnostic accuracy of DIF, IIF SSS, and immunoblot for BP180 and BP230. RESULTS: Of the 787 participants, 121 (15.4%) received the diagnosis of MMP (50 men [41.3%], 71 women [58.7%]; mean [SD] age at diagnosis, 60.1 [17.7] years). Sixty-seven of the patients with MMP (55.4%) had monosite involvement, of which oral site was the most frequently affected (51 [42.1%]). No significant difference was found between the sensitivity of DIF on a perilesional buccal biopsy and a normal buccal biopsy (89.3% vs 76.7%). Three patients with solitary ocular involvement showed a positive DIF of only the oral mucosa. In 6 patients with a negative mucosal DIF, a skin biopsy confirmed diagnosis of MMP. Overall, IIF SSS was less sensitive (44.6%), but highly specific (98.9%). The sensitivity of immunoblot (66.1%) was higher compared to SSS, but with lower specificity (91.3%). CONCLUSIONS AND RELEVANCE: This comparative diagnostic accuracy study of a cohort of 787 patients found a high sensitivity of a mucosal DIF biopsy for diagnosis of MMP, and lower sensitivity of serologic analysis. A biopsy can be taken from either perilesional or normal buccal mucosa. An additional DIF biopsy of another mucosal site or of affected or unaffected skin may increase the diagnostic yield and is recommended in patients with negative DIF results and high clinical suspicion

Diversity und Diversity Management in Berliner Unternehmen: im Fokus: Personen mit Migrationshintergrund ; Ergebnisse einer quantitativen und qualitativen empirischen Studie

"Das vorliegende Buch befasst sich mit der betrieblichen Integration von Personen mit Migrationshintergrund. Im Zentrum stehen die Ergebnisse einer telefonischen Befragung von Personalverantwortlichen in 500 Berliner Unternehmen sowie von 40 darauf aufbauenden Tiefen-Interviews mit verschiedenen betrieblichen Akteuren aus sechs Unternehmen, die zu Fallstudien verdichtet wurden. Damit wird aus Diversity-Perspektive beleuchtet, inwieweit sich die Vielfalt auf dem Berliner Arbeitsmarkt in der Personalstruktur der Unternehmen widerspiegelt und welcher personalpolitische Umgang damit verbunden ist. Auf der Basis der empirischen Befunde sowie weiterer Konzepte zur Förderung von Chancengleichheit werden zudem Ansatzpunkte für das Personalmanagement aufgezeigt: Durch eine entsprechende Organisationsanalyse kann der Handlungsbedarf ermittelt werden. Gezielte Maßnahmen können dann darauf hinwirken, dass die Vielfalt im Unternehmen erhöht wird, Personen mit Migrationshintergrund besser integriert und die Potenziale der Vielfalt genutzt werden." (Autorenreferat

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD), ascertained within the European Early-Onset Dementia consortium. As control dataset, we sequenced 1,625 European control individuals and analyzed whole-exome sequence data of 2,274 German individuals (total n = 3,899). Association of rare SQSTM1 mutations was calculated in a meta-analysis of 4,332 FTLD and 10,240 control alleles. We identified 25 coding variants in FTLD patients of which 10 have not been described. Fifteen mutations were absent in the control individuals (carrier frequency < 0.00026) whilst the others were rare in both patients and control individuals. When pooling all variants with a minor allele frequency < 0.01, an overall frequency of 3.2 % was calculated in patients. Rare variant association analysis between patients and controls showed no difference over the whole protein, but suggested that rare mutations clustering in the UBA domain of SQSTM1 may influence disease susceptibility by doubling the risk for FTLD (RR = 2.18 [95 % CI 1.24-3.85]; corrected p value = 0.042). Detailed histopathology demonstrated that mutations in SQSTM1 associate with widespread neuronal and glial phospho-TDP-43 pathology. With this study, we provide further evidence for a putative role of rare mutations in SQSTM1 in the genetic etiology of FTLD and showed that, comparable to other FTLD/ALS genes, SQSTM1 mutations are associated with TDP-43 pathology

No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients

We evaluated the genetic contribution of the T cell-erestricted intracellular antigen-1 gene (TIA1) in a European cohort of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Exonic resequencing of TIA1 in 1120 patients (693 FTD, 341 ALS, 86 FTD-ALS) and 1039 controls identified in total 5 rare heterozygous missense variants, affecting the TIA1 low-complexity domain (LCD). Only 1 missense variant, p.Met290Thr, identified in a familial FTD patient with disease onset at 64 years, was absent from controls yet received a combined annotation-dependent depletion score of 11.42. By contrast, 3 of the 4 variants also detected in unaffected controls, p.Val294Glu, p.Gln318Arg, and p.Ala381Thr, had combined annotation-dependent depletion scores greater than 20. Our findings in a large European patient-control series indicate that variants in TIA1 are not a common cause of ALS and FTD. The observation of recurring TIA1 missense variants in unaffected individuals lead us to conclude that the exact genetic contribution of TIA1 to ALS and FTD pathogenesis remains to be further elucidated