New results on mixture and exponential models by Orlicz spaces

New results and improvements in the study of nonparametric exponential and mixture models are proposed. In particular, different equivalent characterizations of maximal exponential models, in terms of open exponential arcs and Orlicz spaces, are given. Our theoretical results are supported by several examples and counterexamples and provide an answer to some open questions in the literature.Comment: Published at http://dx.doi.org/10.3150/15-BEJ698 in the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Exploring the link among state of mind concerning childhood attachment, attachment in close relationships, parental bonding, and psychopathological symptoms in substance users

In the present study, we have explored the link among styles of attachment and psychopathology in drug users. We know that insecure attachment predisposes the individuals the development of drug-addiction and psychopathological symptoms. However, we do not know which attachment is more frequent in drug users and which is related to particular psychopathological symptoms. The aim of the present work is to explore the relationship between childhood attachment state of mind, attachment in close relationships, parental bonding and psychopathology in sample of Italian substance users

“Scavar tra le carte”. Quale nesso tra speleologia e archivi?

Gli archivi conservano un enorme patrimonio di informazioni relative anche alle esplorazioni nel territorio. Scoprire motivazioni, tecniche, successi e insuccessi degli speleologi del passato, leggere le relazioni, conoscere le aspettative, valutare i risultati e ripercorrere il filo rosso, che unisce l’attività sul campo di oggi a quella di ieri, può avere un fascino tutto particolare. La bibliografia testimonia che i fondi dell’Archivio Generale del Comune di Trieste sono stati ben indagati per la documentazione fino al 1850 e le carte hanno già svelato molte storie e scoperte del passato, legate soprattutto alla ricerca dell’acqua in zona carsica. Una panoramica tra le fonti disponibili e le tecniche di ricerca possibili tenterà di fare luce sui temi di interesse speleologico e scientifico più ricorrenti, in particolare tra i documenti degli anni successivi al 1850, in modo da offrire, a chi volesse documentarsi, le giuste chiavi di accesso per calarsi anche tra le carte e trovare nel passato risorse utili per le esplorazioni di domani.Archives keep a rich inheritance of information about land exploration. It could be rather fascinating to discover earlier speleologists strivings, techniques, successes and misfortunes, as well as to judge their achievements and to seek for what connects contemporary work on the land with earlier research. Bibliography shows that the collections of records possessed by Archivio Generale del Comune di Trieste are well studied with respect to documents up to 1850; many stories and early discoveries have already been revealed, in particular about the search for water in Karst. A survey of available sources and research methods will try to enlighten some well-attested themes of speleological and scientific interest, focusing in particular on documents following 1850. This way anyone who might refer to documents can have a key to explore even archival collections, and to find in the past useful tools for tomorrow’s explorations

Caenorhabditis elegans and probiotics interactions from a prolongevity perspective

Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation. In the context of ageing, which is characterized by several physiological alterations leading to a low grade inflammatory status called inflammageing, evidences suggest a potential prolongevity role of probiotics. Unraveling the mechanisms underlying anti-ageing effects requires the use of simple model systems. To this respect, the nematode Caenorhabditis elegans represents a suitable model organism for the study of both host-microbe interactions and for ageing studies, because of conserved signaling pathways and host defense mechanisms involved in the regulation of its lifespan. Therefore, this review analyses the impact of probiotics on C. elegans age-related parameters, with particular emphasis on oxidative stress, immunity, inflammation and protection from pathogen infections. The picture emerging from our analysis highlights that several probiotic strains are able to exert anti-ageing effects in nematodes by acting on common molecular pathways, such as insulin/insulin-like growth factor-1 (IIS) and p38 mitogen-activated protein kinase (p38 MAPK). In this perspective, C. elegans appears to be advantageous for shedding light on key mechanisms involved in host prolongevity in response to probiotics supplementation

Mutual Inductance Route to Paramagnetic Meissner Effect in 2D Josephson Junction Arrays

We simulate two-dimensional Josephson junction arrays, including full mutual- inductance effects, as they are cooled below the transition temperature in a magnetic field. We show numerical simulations of the array magnetization as a function of position, as detected by a scanning SQUID which is placed at a fixed height above the array. The calculated magnetization images show striking agreement with the experimental images obtained by A. Nielsen et al. The average array magnetization is found to be paramagnetic for many values of the applied field, confirming that paramagnetism can arise from magnetic screening in multiply-connected superconductors without the presence of d-wave superconductivity.Comment: REVTeX 3.1, 5 pages, 5 figure

Efficient taxation of multi-national enterprises in the European Union. Bruges European Economic Policy (BEEP) Briefing 5/2003

Current arrangements for multi-national company taxation in EU are plagued by severe conceptual and administrative problems, leading to high compliance costs, considerable uncertainty and ample room for abuse. Integration is amplifying these difficulties. There are two possible approaches in designing an efficient trans-border corporate tax system for the European Union. The first is to consolidate the EU-wide operations of MNEs, using an agreed common base as the reference variable, and then to apportion this total tax base using some presumptive indicators of activity in each tax jurisdiction – hence, implicitly, of the likely benefits stemming from each location. The apportionment formula should respect requisites of neutrality between productive factors and forms of corporate financing. A radically different approach is also available that offers considerable advantages in terms of efficiency, simplicity and decentralisation, including full administrative autonomy of national tax authorities. It entails abandoning corporate income as the relevant tax base and taxing at a moderate rate some agreed measure of business activity such as company value added, sales or employment. These are the variables usually considered in formula apportionment, but they would apply directly without having first to go through the complications of EU-wide consolidation based on a common-base definition. Reference to a broad base, with no exemptions or deductions, would allow to set low statutory rates

Exponential models by Orlicz spaces and applications

We use maximal exponential models to characterize a suitable polar cone in a mathematical convex optimization framework. A financial application of this result is provided, leading to a duality minimax theorem related to portfolio exponential utility maximization

Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations

This book aims to summarize the latest advances in the rheumatic diseases, particularly regarding their pathophysiology and targeted therapy, with a focus on the recent efforts of vascular and pulmonary manifestations in order to anticipate new and future directions of these research topics. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the diversity and complexity of vascular and pulmonary manifestations of rheumatic diseases and to highlight gaps in our knowledge of how to effectively manage them. Despite their significant morbidity, we have a limited understanding of their pathogenesis. The eleven published articles reported here underline the complexity of rheumatic diseases and the difficulty of managing them. The manuscripts provide an overview of the pathophysiology and current management approach of these disorders, highlighting tools that assist with diagnosis, risk stratification, and therapy. A significant number of articles have reported innovative and effective treatments for the most frequent and debilitating complications of rheumatic diseases. The book emphasizes the importance of multidisciplinary teams using the skills of laboratory researchers, clinicians, radiologists, and pathologists. Furthermore, recent findings are presented and discussed, highlighting strategies to combat worsening symptoms of rheumatic diseases. The research described in this book provide an extremely useful example of the results achieved in the field of anti-rheumatic drug development. Detailed information on new breakthroughs can be found in this book. We strongly encourage a wide group of readers to explore the book that we are presenting for inspiration to develop new approaches to the diagnosis and treatment of rheumatic diseases

A Preliminary LCA Analysis of Snowmaking in Fiemme Valley

Modern ski resorts have been using systems of technical snow for many years: initially they were used to compensate the limits of natural snow but today it is actually the natural snow that is used as an integration to artificial snow and not vice versa. This paper aims to identify and evaluate the environmental impacts associated to the production of artificial snow, comparing two very different winter seasons in terms of snowfalls. The results of LCA analysis shows that the production of artificial snow primarily implies impacts on natural land transformation and fossil depletion, and that more snowfalls cause more onerous skiing resorts management, due to high consumption of diesel fuel for piste machines used for snow grooming