A Distributed Routing Algorithm for Internet-wide Geocast

Geocast is the concept of sending data packets to nodes in a specified geographical area instead of nodes with a specific address. To route geocast messages to their destination we need a geographic routing algorithm that can route packets efficiently to the devices inside the destination area. Our goal is to design an algorithm that can deliver shortest path tree like forwarding while relying purely on distributed data without central knowledge. In this paper, we present two algorithms for geographic routing. One based purely on distance vector data, and one more complicated algorithm based on path data. In our evaluation, we show that our purely distance vector based algorithm can come close to shortest path tree performance when a small number of routers are present in the destination area. We also show that our path based algorithm can come close to the performance of a shortest path tree in almost all geocast situations

Spaceprint: a Mobility-based Fingerprinting Scheme for Public Spaces

In this paper, we address the problem of how automated situation-awareness can be achieved by learning real-world situations from ubiquitously generated mobility data. Without semantic input about the time and space where situations take place, this turns out to be a fundamental challenging problem. Uncertainties also introduce technical challenges when data is generated in irregular time intervals, being mixed with noise, and errors. Purely relying on temporal patterns observable in mobility data, in this paper, we propose Spaceprint, a fully automated algorithm for finding the repetitive pattern of similar situations in spaces. We evaluate this technique by showing how the latent variables describing the category, and the actual identity of a space can be discovered from the extracted situation patterns. Doing so, we use different real-world mobility datasets with data about the presence of mobile entities in a variety of spaces. We also evaluate the performance of this technique by showing its robustness against uncertainties

Latitude, longitude, and beyond:mining mobile objects' behavior

Rapid advancements in Micro-Electro-Mechanical Systems (MEMS), and wireless communications, have resulted in a surge in data generation. Mobility data is one of the various forms of data, which are ubiquitously collected by different location sensing devices. Extensive knowledge about the behavior of humans and wildlife is buried in raw mobility data. This knowledge can be used for realizing numerous viable applications ranging from wildlife movement analysis, to various location-based recommendation systems, urban planning, and disaster relief. With respect to what mentioned above, in this thesis, we mainly focus on providing data analytics for understanding the behavior and interaction of mobile entities (humans and animals). To this end, the main research question to be addressed is: How can behaviors and interactions of mobile entities be determined from mobility data acquired by (mobile) wireless sensor nodes in an accurate and efficient manner? To answer the above-mentioned question, both application requirements and technological constraints are considered in this thesis. On the one hand, applications requirements call for accurate data analytics to uncover hidden information about individual behavior and social interaction of mobile entities, and to deal with the uncertainties in mobility data. Technological constraints, on the other hand, require these data analytics to be efficient in terms of their energy consumption and to have low memory footprint, and processing complexity

Unsupervised Discretization by Two-dimensional MDL-based Histogram

Unsupervised discretization is a crucial step in many knowledge discovery tasks. The state-of-the-art method for one-dimensional data infers locally adaptive histograms using the minimum description length (MDL) principle, but the multi-dimensional case is far less studied: current methods consider the dimensions one at a time (if not independently), which result in discretizations based on rectangular cells of adaptive size. Unfortunately, this approach is unable to adequately characterize dependencies among dimensions and/or results in discretizations consisting of more cells (or bins) than is desirable. To address this problem, we propose an expressive model class that allows for far more flexible partitions of two-dimensional data. We extend the state of the art for the one-dimensional case to obtain a model selection problem based on the normalised maximum likelihood, a form of refined MDL. As the flexibility of our model class comes at the cost of a vast search space, we introduce a heuristic algorithm, named PALM, which partitions each dimension alternately and then merges neighbouring regions, all using the MDL principle. Experiments on synthetic data show that PALM 1) accurately reveals ground truth partitions that are within the model class (i.e., the search space), given a large enough sample size; 2) approximates well a wide range of partitions outside the model class; 3) converges, in contrast to its closest competitor IPD; and 4) is self-adaptive with regard to both sample size and local density structure of the data despite being parameter-free. Finally, we apply our algorithm to two geographic datasets to demonstrate its real-world potential.Comment: 30 pages, 9 figure

Spaceprint: a Mobility-based Fingerprinting Scheme for Spaces

In this paper, we address the problem of how automated situational awareness in a specifi c location can be achieved by characterizing the fingerprint of recurrent situations from ubiquitously generated mobility data. Without semantic input about the time and space (location) where situations take place, this turns out to be a fundamental challenging problem. Uncertainties in data also introduce technical challenges when data is generated in irregular time intervals, being mixed with noise, and errors. Purely relying on temporal patterns observable in mobility data, in this paper, we propose Spaceprint, a fully automated algorithm for fi nding the repetitive pattern of similar situations in spaces. We evaluate this technique by showing how the latent variables describing the actual identity of a space can be discovered from the extracted situation patterns

Joint Geographical and Temporal Modeling based on Matrix Factorization for Point-of-Interest Recommendation

With the popularity of Location-based Social Networks, Point-of-Interest (POI) recommendation has become an important task, which learns the users' preferences and mobility patterns to recommend POIs. Previous studies show that incorporating contextual information such as geographical and temporal influences is necessary to improve POI recommendation by addressing the data sparsity problem. However, existing methods model the geographical influence based on the physical distance between POIs and users, while ignoring the temporal characteristics of such geographical influences. In this paper, we perform a study on the user mobility patterns where we find out that users' check-ins happen around several centers depending on their current temporal state. Next, we propose a spatio-temporal activity-centers algorithm to model users' behavior more accurately. Finally, we demonstrate the effectiveness of our proposed contextual model by incorporating it into the matrix factorization model under two different settings: i) static and ii) temporal. To show the effectiveness of our proposed method, which we refer to as STACP, we conduct experiments on two well-known real-world datasets acquired from Gowalla and Foursquare LBSNs. Experimental results show that the STACP model achieves a statistically significant performance improvement, compared to the state-of-the-art techniques. Also, we demonstrate the effectiveness of capturing geographical and temporal information for modeling users' activity centers and the importance of modeling them jointly.Comment: To be appear in ECIR 202

Editorial: Innovative approaches in drug discovery and development

Abstract non availabl

Survivin Mutant Protects Differentiated Dopaminergic SK-N-SH Cells Against Oxidative Stress

Oxidative stress is due to an imbalance of antioxidant/pro-oxidant homeostasis and is associated with the progression of several neurological diseases, including Parkinson's and Alzheimer's disease and amyotrophic lateral sclerosis. Furthermore, oxidative stress is responsible for the neuronal loss and dysfunction associated with disease pathogenesis. Survivin is a member of the inhibitors of the apoptosis (IAP) family of proteins, but its neuroprotective effects have not been studied. Here, we demonstrate that SurR9-C84A, a survivin mutant, has neuroprotective effects against H2O2-induced neurotoxicity. Our results show that H2O2 toxicity is associated with an increase in cell death, mitochondrial membrane depolarisation, and the expression of cyclin D1 and caspases 9 and 3. In addition, pre-treatment with SurR9-C84A reduces cell death by decreasing both the level of mitochondrial depolarisation and the expression of cyclin D1 and caspases 9 and 3. We further show that SurR9-C84A increases the antioxidant activity of GSH-peroxidase and catalase, and effectively counteracts oxidant activity following exposure to H2O2. These results suggest for the first time that SurR9-C84A is a promising treatment to protect neuronal cells against H2O2-induced neurotoxicity