A Straightforward Framework for Road Network Screening to Lombardy Region (Italy)

It is not possible to deal with sustainable mobility without considering road safety as a key element: Target 3.6 of the Sustainable Development Goals aims at halving the number of road deaths by 2030. To do so, further effort and effective tools are required for road authorities, to implement improvement measures and enhance road safety for all. Road network screening (RNS) is the first step of the whole Road Infrastructure Safety Management (RISM) System process. It is applied to a wide scale to assess the safety performance of the whole road network and identify the worst performing roads (or sites). The literature is quite rich with RNS models and methods, which have greatly improved, recently. Moreover, although many national frameworks on road safety have been issued over time, some barriers remain, specifically related to data quality, such as accurate crash location, which is mainly used to integrate crash data with other databases. In addition, most of these frameworks adopted partial indexes to identify black spots and presented results using fixed maps for visualization. This paper fills these gaps by the proposal of a straightforward operational framework to perform RNS, based on a simple and flexible rationale to integrate raw crash, traffic, and road data. Specifically, the framework: (i) manages crash location data, without relying on plane or geographical coordinates, which are missing or inaccurate and still are a crucial issue in many European countries such as Italy; (ii) adopts an adjusted accident cost rate index that integrates frequency and severity of crashes as well as a measurement of exposure; (iii) introduces variable maps that show the results at different jurisdiction levels. A relevant case study demonstrates the usefulness of this framework using 30,000+ crash data of the whole non-urban road network of the Lombardy Region (Northern Italy). Road authorities could adopt this framework to perform an accurate safety screening on the overall regional road network. Moreover, this framework could be implemented in a road traffic safety managerial system to better prioritise safety interventions within a tight budget and help achieve sustainable development targets

Sustainable cycle-tourism for society: Integrating multi-criteria decision-making and land use approaches for route selection

Cycle tourism is a sustainable active vacation, which is quickly growing in recent years. Although it has several benefits for society and users (e.g., social connections, amusement, and physical and mental health), cycle tourism requires an adequate route network to enjoy destinations with historical and landscape peculiarities. Past literature mainly investigated motivations and preferences for cycle tourists and proposed optimisation methods in planning routes. However, applying assessment methods for prioritising cycle-tourist routes is a seldom-explored topic. This study aims to address this gap by applying an integrated method for evaluating and prioritising cycle routes, searching for a compromise between route characteristics, service provided to users, and natural and building contexts crossed. It jointly includes Multi-Criteria Decision Methods (MCDMs) and a land use approach: AHP determines the weights of criteria and parameters describing cycle routes; GIS elaborates spatial analysis of parameters; ELECTRE I and VIKOR help find a compromise solution amongst different cycle routes. The integrated method involved a panel of experts to collect data, and it is applied to the wide-study area of Franciacorta (Italy). Some comparisons with other MCDMs are made to justify the results. The findings could support multi-institutions prioritising cycle route alternatives in deciding their building

The intriguing case of motor neuron disease: ALS and SMA come closer

MNDs (motor neuron diseases) form a heterogeneous group of pathologies characterized by the progressive degeneration of motor neurons. More and more genetic factors associated with MND encode proteins that have a function in RNA metabolism, suggesting that disturbed RNA metabolism could be a common underlying problem in several, perhaps all, forms of MND. In the present paper we review recent developments showing a functional link between SMN (survival of motor neuron), the causative factor of SMA (spinal muscular atrophy), and FUS (fused in sarcoma), a genetic factor in ALS (amyotrophic lateral sclerosis). SMN is long known to have a crucial role in the biogenesis and localization of the spliceosomal snRNPs (small nuclear ribonucleoproteins), which are essential assembly modules of the splicing machinery. Now we know that FUS interacts with SMN and pathogenic FUS mutations have a significant effect on snRNP localization. Together with other recently published evidence, this finding potentially links ALS pathogenesis to disturbances in the splicing machinery, and implies that pre-mRNA splicing may be the common weak point in MND, although other steps in mRNA metabolism could also play a role. Certainly, further comparison of the RNA metabolism in different MND will greatly help our understanding of the molecular causes of these devastating diseases

Measuring Safety Performance in the extra-urban Road Network of Lombardy Region (Italy)

Road Network Screening (RNS) is a process to evaluate the safety performance of the whole road network and identify worst performing roads. Currently, literature provides many models and methods for RNS. Moreover, several frameworks of RNS were issued at the European National Level over time. However, even if sophisticated models and methods could be preferable for their computational accuracy, they may be far from the capabilities of practitioners. In addition, other issues such as availability of operative attributes and data quality and processing persist. For instance, accurate crash location, which is crucial for detailed analyses of high crash rates at some locations, is still an issue: many road administrations pointed out that coordinates miss or are inaccurate in many cases. Within this context, this paper proposes a straightforward operational framework to evaluate safety performance for RNS, using a flexible rationale that integrates crash, traffic, and road data, respectively. More precisely, this framework: (a) handles crash location data without using spatial coordinates; (b) computes the crash rate index at different administrative levels; (c) shows results by Geographic Information System (GIS) maps. This framework is applied to the whole extra-urban road network of the Lombardy Region (Northern Italy) using 30.000+ crash data provided by the Regional Institute for Lombardy Policy Support (PoliS). Road authorities could adopt this framework to perform an accurate safety screening on the road network aimed at rational planning of safety interventions

Kinematic performance of micro-mobility vehicles during braking: experimental analysis and comparison between e-kick scooters and bikes

According to the Italian legislation, e-kick scooters and bikes are considered a single category of vehicles and can travel on the same infrastructures with the same rules; however, their kinematic behavior is very different. The adoption of a bike as a vehicle for covering short distances i.e., within 5 km is widely known both at the kinematic level and for its use by users. Conversely, e-kick scooters are "unknown" vehicles both for their kinematic characteristics and for their use by users. A handful of studies have shown how the behavior of e-kick scooters and bikes is very different; however, there are not many studies that analyze the different kinematic behavior of e-kick scooters and bikes. This study presents an experimental analysis that evaluates braking behavior by comparing e-kick scooters and traditional bikes according to several vehicle speeds. These analyzes help build a probabilistic mathematical model for estimating the stopping space of e-kick scooters and bikes. The availability of this model is crucial for the design of safe intersections between cycle paths and roads intended for motor vehicle traffic. Moreover, this model may reveal insights that could challenge the recent European regulations that equated e-kick scooters as bikes

A comparative cycling path selection for sustainable tourism in Franciacorta. An integrated AHP-ELECTRE method

Cycle tourism is a form of sustainable itinerant tourism expanding in Italy and the rest of the world, with prospects for growth in coming years. Europe and North America have already developed a wide range of cycling infrastructures tied to tourism experiences. Benefits induced are generally recognised: first, it is a sustainable solution that increases local economics while conserving the environment; second, it guarantees advantages on social connections, amusement, and physical and mental health. However, it requires an adequate network to enjoy destinations as historical and landscape peculiarities. Currently, literature provides some methods for planning itineraries dedicated to cycle tourism. Despite that, there is less attention on how evaluating existing or already planned tourist itineraries. This study covers this gap, by applying an integrated method to assess bicycle connections for tourism experiences within municipalities. Since this evaluation may contain many conflicting criteria (e.g., preferences of public administrator, technical and economic viability) and possible alternatives, this study frames the method as a multi-criteria decision-making problem (MCDM). Specifically, at first, the Analytical Hierarchy Process (AHP) is adopted to calculate weights for each criterium; next, the ELimination Et Choix Traduisant la REalitè (ELECTRE) method is applied to provide a (possible) priority ranking of cycling tourist paths among alternatives, by computing indices of discordance and concordance between pairs of alternatives. The framework is applied to the Franciacorta area (North-East Italy), a national and international tourist relevance territory encompassing 22 municipalities. This study may be useful for public administrators to rationalise and prioritise cycling routes

A new methodology for accidents analysis: The case of the state road 36 in Italy

6noEvery year more than 1.35 million people die for road accidents and several million suffer serious injuries, which force them to live with compromised health conditions. Over the last decades, road safety research has focused on improving modelling techniques. However, due to the lack of expertise and statistical skills, such approaches might not be used by local authorities and road managers for road safety evaluation purposes. This paper proposes an operational methodology to analyze road accidents with the aim of increasing road safety. More specifically, the methodology enables to identify the most critical road segments to prioritize economic resources allocation accordingly. By using the data collected by the Road Police Department of Lombardy Region (in Italy) from 2014 to 2018, this methodology has been successfully applied to State Road 36, which is recognized as one of the busiest roads in Italy with a very high number of accidents occurring every year. The proposed methodology may support public administrations and road managers - involved in the definition and implementation of safety measures - to reduce the number of road accidents identifying and implementing prioritized interventions. Moreover, the methodology is general enough to be applied to each segment of a generic road infrastructure.openopenBorghetti F.; Marchionni G.; De Bianchi M.; Barabino B.; Bonera M.; Caballini C.Borghetti, F.; Marchionni, G.; De Bianchi, M.; Barabino, B.; Bonera, M.; Caballini, C

A practical approach to the use of low molecular weight heparins in VTE treatment and prophylaxis in children and newborns.

Low-molecular weight heparins are currently the most commonly used anticoagulants in children and newborns. However, since thrombotic complications rarely occur outside large children’s hospitals, physicians often encounter some practical problems inmanaging these treatments when a pediatric thrombosis specialist is not available. The drug of choice is enoxaparin, due to its favorable FXa/FIIa ratio and the availability of pharmacokinetic and pharmacodynamic data. The treatment of acute thrombosis should be started with two daily injections but when compliance is an issue, a single daily administration schedule could be chosen for secondary prophylaxis ensuring careful measurement of the post 24-hour anti-FXa activity. Furthermore, a subcutaneous device may be a useful tool and a topical dermal anesthetic could be effective in controlling pain without affecting anti-FXa levels. In neonate and toddlers, where mini doses are frequently needed, the dead space of syringes and needles could represent an issue and therefore the use of insulin syringes without dead space is advisable,while a dilution of the drug is useful with other syringes. This article derives froma nonsystematic review of the available literature, with special attention to recent international guidelines and expert recommendations, combined to authors’ clinical practice in large tertiary pediatric hospitals and will provide concise and practical information for the use of low-molecular weight heparin in childhood and infancy in a sort of “answering frequently asked questions.

Spatial Engineering of Osteochondral Tissue Constructs Through Microfluidically Directed Differentiation of Mesenchymal Stem Cells

The development of tissue engineered osteochondral units has been slowed by a number of technical hurdles associated with recapitulating their heterogeneous nature ex vivo. Subsequently, numerous approaches with respect to cell sourcing, scaffolding composition, and culture media formulation have been pursued, which have led to high variability in outcomes and ultimately the lack of a consensus bioprocessing strategy. As such, the objective of this study was to standardize the design process by focusing on differentially supporting formation of cartilaginous and bony matrix by a single cell source in a spatially controlled manner within a single material system. A cell-polymer solution of bovine mesenchymal stem cells and agarose was cast against micromolds of a serpentine network and stacked to produce tissue constructs containing two independent microfluidic networks. Constructs were fluidically connected to two controlled flow loops and supplied with independently tuned differentiation parameters for chondrogenic and osteogenic induction, respectively. Constructs receiving inductive media showed differential gene expression of both chondrogenic and osteogenic markers in opposite directions along the thickness of the construct that was recapitulated at the protein level with respect to collagens I, II, and X. A control group receiving noninductive media showed homogeneous expression of these biomarkers measured in lower concentrations at both the mRNA and protein level. This work represents an important step in the rational design of engineered osteochondral units through establishment of an enabling technology for further optimization of scaffolding formulations and bioprocessing conditions toward the production of commercially viable osteochondral tissue products

Real-time evaluation of the on-board comfort of standing passenger in bus transit services

Bus on-board comfort may be intended as a multidimensional concept declined according to several attributes (e.g., vibrations, the load factor, the driving style, etc.) and represents a key factor of service quality. Thus, its measurement is crucial for public transport companies as it can support for the monitoring, evaluation and implementation of specific actions to improve their services. The objective of this paper is to build a numerical scale for real-time measurement of bus on-board comfort. This is pursued integrating subjective measurements of the driving style provided by the passengers with objective ones of longitudinal and transversal accelerations data collected by Intelligent Transportation System tools. The results are very useful because they represent a contribution to establish a comfort scale in a real operational environment, as a tool to regulate the driver's behavior: each driver is in the position of real-time monitoring the quality of a bus ride regarding on-board comfort level