22 research outputs found
The Elusive Boundaries of Social Work
Repeated attempts to conceptualize social work have assumed that social work should and can have a precisely defined domain. One suggestion is to equate social work with personal social services. This article suggests that the uniqueness of social work lies in the very absence of defined boundaries. Implications for social work practice are identified, in particular social work\u27s heavy dependence on resource controllers, and the consequent need of social work education to shift its traditional focus from client-centered interventions to managing non-client interactions
Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1
Natural killer (NK) cells are innate cytotoxic lymphocytes that specialize in the defense against viral infection and oncogenic transformation. Their action is tightly regulated by signals derived from inhibitory and activating receptors; the later include proteins such as the Natural Cytotoxicity Receptors (NCRs: NKp46, NKp44 and NKp30). Among the NCRs, NKp46 is the only receptor that has a mouse orthologue named Ncr1. NKp46/Ncr1 is also a unique marker expressed on NK and on Lymphoid tissue inducer (LTI) cells and it was implicated in the control of various viral infections, cancer and diabetes. We have previously shown that human NKp46 recognizes viral hemagglutinin (HA) in a sialic acid-dependent manner and that the O-glycosylation is essential for the NKp46 binding to viral HA. Here we studied the molecular interactions between Ncr1 and influenza viruses. We show that Ncr1 recognizes influenza virus in a sialic acid dependent manner and that N-glycosylation is important for this binding. Surprisingly we demonstrate that none of the predicted N-glycosilated residues of Ncr1 are essential for its binding to influenza virus and we thus conclude that other, yet unidentified N-glycosilated residues are responsible for its recognition. We have demonstrated that N glycosylation play little role in the recognition of mouse tumor cell lines and also showed the in-vivo importance of Ncr1 in the control of influenza virus infection by infecting C57BL/6 and BALB/c mice knockout for Ncr1 with influenza
Structuring effect of tools conceptualized through initial goal fixedness for work activity
Analysis of work activities in nuclear industry has highlighted a new psycho-cognitive phenomenon: the structuring effect of tools (SET) sometimes leading to unexpected operating deviations; the subject is unable to perform a task concerning object A using or adapting a tool designed and presented to perform the same task concerning object B when object A is expected by the subject. Conditions to isolate and identify the SET were determined and reproduced in experiments for further analysis. Students and seven professional categories of adults (N = 77) were involved in three experimental conditions (control group, group with prior warning, group with final control) while individually performing a task with similar characteristics compared to real operating conditions and under moderate time-pressure. The results were: (1) highest performance with prior warning and (2) demonstration that academic and professional training favor the SET. After discussing different cognitive processes potentially related to the SET, we described (3) the psycho-cognitive process underlying the SET: Initial Goal Fixedness (IGF), a combination of the anchoring of the initial goal of the activity with a focus on the features of the initial goal favored by an Einstellung effect. This suggested coping with the negative effect of the SET by impeding the IGF rather than trying to increase the subjects’ awareness at the expense of their health. Extensions to other high-risk industries were discussed
Development of Palestinian Social Work in Israel: The Formative Years (1968–1982)
Based on primary and secondary sources and interviews with Arab social workers employed in welfare bureaus during the time under review, the article describes the development of Palestinian social work in Israel in its formative years (1968–1982). The primary finding is that this development took place under a policy of contempt towards the Palestinian community\u27s needs. The authorities acknowledged these needs but perpetuated a discriminatory allocation of resources in meeting them compared to Jewish Israelis and disregarded the society\u27s narrative by maintaining a dual welfare system: one for the country\u27s Jewish citizens and a lesser one for their Arab compatriots