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This paper investigates the problem of H∞ fuzzy control for a class of nonlinear singular Markovian jump systems with time delay. This class of systems under consideration is described by Takagi-Sugeno (T-S) fuzzy models. Firstly, sufficient condition of the stochastic stabilization by the method of the augmented matrix is obtained by the state feedback. And a designed algorithm for the state feedback controller is provided to guarantee that the closed-loop system not only is regular, impulse-free, and stochastically stable but also satisfies a prescribed H∞ performance for all delays not larger than a given upper bound in terms of linear matrix inequalities. Then H∞ fuzzy control for this kind of systems is also discussed by the static output feedback. Finally, numerical examples are given to illustrate the validity of the developed methodology

Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study

AbstractObjectiveTo evaluate the self-efficacy and satisfaction of asthma patients subjected to summer acupoint application treatment (SAAT).MethodsA two-year follow-up clinical study was conducted. Patients with asthma were treated by applying a herbal paste onto the Feishu (BL 13) and Fengmen (BL 12) acupoints on the three hottest days of summer, according to the traditional Chinese calendar, from 2008 to 2010. During a two-year follow-up, these patients were asked to fill out a questionnaire evaluating asthma degree, exacerbation frequency, concomitant medications and self-satisfaction. The self-rate and doctor-report outcomes obtained in parallel were evaluated to assess the efficacy of SAAT.ResultsA total of 527 asthma patients were initially enrolled in this study, of which 97 elderly patients and those with more severe cases of asthma were lost to follow-up. Thus, a total of 430 patients were valid for analysis using self-rate data. Nevertheless, occasional negative returns were obtained; almost all of the outcomes were rated as “No change”, “Moderate effective”, or “Very effective”. In addition, 80% of the patients were satisfied with this treatment. Moreover, 391 (91.4%) patients were somewhat improved after SAAT in 2009, and further improvement was observed in 2010. After SAAT, the average asthma-degree score decreased from 5.3 in 2008 to 4 in 2009 and, subsequently to 3.5 in 2010.ConclusionWith pronounced patient satisfaction, SAAT can reduce the exacerbation severity and frequency, concomitant medications and asthma degree. Prolonging the treatment course might enhance the efficacy of SAAT

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network.

Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb-compound-target relationships. In this work, we present an Herb-Target Interaction Network (HTINet) approach, a novel network integration pipeline for herb-target prediction mainly relying on the symptom related associations. HTINet focuses on capturing the low-dimensional feature vectors for both herbs and proteins by network embedding, which incorporate the topological properties of nodes across multi-layered heterogeneous network, and then performs supervised learning based on these low-dimensional feature representations. HTINet obtains performance improvement over a well-established random walk based herb-target prediction method. Furthermore, we have manually validated several predicted herb-target interactions from independent literatures. These results indicate that HTINet can be used to integrate heterogeneous information to predict novel herb-target interactions

Apexification Management of Mandibular Second Premolar with a Blunderbuss Apex and Periapical Lesion of an Adult Patient

Apexification is widely applied in teenager patients but rarely used in the adult population. Instead, artificial apical barrier with mineral trioxide aggregate (MTA) is clinically accepted, and spontaneous apical closure in nonvital immature teeth of adult patients has rarely been encountered while only apexification of the maxillary incisors in adult patients has been reported. The aim of this case report is to share a successful apexification application in the mandibular premolar with a blunderbuss apex and periapical lesion of an adult patient by using calcium hydroxide: radiographically, spontaneous hard tissue barrier has been established, and narrowing canal space and decreasing area of periapical shadow were documented without complications. Taken together, our study indicates that patient\u27s age and tooth position may not be the critical limitation for apexification. © 2019 Chenshuang Li et al

Early Holocene monsoon instability and climatic optimum recorded by Chinese stalagmites

The timing and duration of the Holocene East Asian summer monsoon (EASM) maximum and the interpretation of Chinese stalagmite δ18O records have long been disputed. Notably, interpretations of Holocene EASM variations are frequently based on a single record or study area and are often contradictory. In this study, we conducted stable isotope analyses of four Holocene stalagmites from Chongqing, southwest China. The results reveal differences in the timing of the Holocene EASM maximum and to try to resolve the inconsistency we analyzed and statistically integrated a total of 16 Holocene stalagmite records from 14 caves in the EASM region. The resulting synthesized Holocene stalagmite δ18O (δ18Osyn) record is in agreement with other EASM records and confirms that stalagmite δ18O records are a valid indicator of EASM intensity, rather of local precipitation amount. The δ18Osyn record shows that the EASM intensified rapidly from the onset of the early Holocene; notably, however, there were distinct EASM oscillations in the early Holocene, consisting of three abrupt millennial-scale events. This indicates that, contrary to several previous interpretations, the early Holocene EASM was unstable. Subsequently, during 8–6 kyr BP, the EASM was relatively stable and strong, with the strongest monsoon occurring during 8–7 kyr BP. This evidence of a stable and strong mid-Holocene EASM in eastern China is in accord with the classical view of a mid-Holocene Optimum in China

7. 直腸閉鎖の一治験例(第510回千葉医学会例会 第7回佐藤外科例会)

The chronological course of foliar NtARF8, NtARF17, and NtARF19 expression during the vegetative growth process. (PDF 40 kb

Chaotic Path Planner of Autonomous Mobile Robots Based on the Standard Map for Surveillance Missions

This paper proposes a fusion iterations strategy based on the Standard map to generate a chaotic path planner of the mobile robot for surveillance missions. The distances of the chaotic trajectories between the adjacent iteration points which are produced by the Standard map are too large for the robot to track. So a fusion iterations strategy combined with the large region iterations and the small grids region iterations is designed to resolve the problem. The small region iterations perform the iterations of the Standard map in the divided small grids, respectively. It can reduce the adjacent distances by dividing the whole surveillance workspace into small grids. The large region iterations combine all the small grids region iterations into a whole, switch automatically among the small grids, and maintain the chaotic characteristics of the robot to guarantee the surveillance missions. Compared to simply using the Standard map in the whole workspace, the proposed strategy can decrease the adjacent distances according to the divided size of the small grids and is convenient for the robot to track

Electrochemical properties of manganese ferrite-based supercapacitors in aqueous electrolyte: the effect of ionic radius

The electrochemical performances of symmetric supercapacitors assembled by MnFeO colloidal nanocrystal clusters (CNCs) in aqueous electrolytes were investigated by using cyclic voltammetry, galvanostatic charge-discharge, cycle stability and electrochemical impedance spectroscopy. Results showed that the capacitance of MnFeO CNCs can be easily adjusted by the controlled electrolytes. It was found that the specific capacitances of CNCs-based electrodes were 97.1, 93.9, 74.2 and 47.4Fg for the electrolytes (2M) containing KOH, NaOH, LiOH and NaSO, respectively, at the current density of 0.1Ag. The capacitance of the electrode was increased from 56.9 to 152.5Fg with aqueous KOH electrolytes changed from 0.5M to 6M. The MnFeO CNCs-based supercapacitor using aqueous KOH (6M) electrolyte displayed the best cycle stability among all the supercapacitors. Based on the experimental results, the enhancement mechanism of electrochemical performances for the CNCs-based supercapacitors was proposed

Cerebral endothelial cell derived small extracellular vesicles improve cognitive function in aged diabetic rats

Small extracellular vesicles (sEVs) mediate cell-cell communication by transferring their cargo biological materials into recipient cells. Diabetes mellitus (DM) induces cerebral vascular dysfunction and neurogenesis impairment, which are associated with cognitive decline and an increased risk of developing dementia. Whether the sEVs are involved in DM-induced cerebral vascular disease, is unknown. Therefore, we studied sEVs derived from cerebral endothelial cells (CEC-sEVs) of aged DM rats (DM-CEC-sEVs) and found that DM-CEC-sEVs robustly inhibited neural stem cell (NSC) generation of new neuroblasts and damaged cerebral endothelial function. Treatment of aged DM-rats with CEC-sEVs derived from adult healthy normal rats (N-CEC-sEVs) ameliorated cognitive deficits and improved cerebral vascular function and enhanced neurogenesis. Intravenously administered N-CEC-sEVs crossed the blood brain barrier and were internalized by neural stem cells in the neurogenic region, which were associated with augmentation of miR-1 and -146a and reduction of myeloid differentiation primary response gene 88 and thrombospondin 1 proteins. In addition, uptake of N-CEC-sEVs by the recipient cells was mediated by clathrin and caveolin dependent endocytosis signaling pathways. The present study provides ex vivo and in vivo evidence that DM-CEC-sEVs induce cerebral vascular dysfunction and neurogenesis impairment and that N-CEC-sEVs have a therapeutic effect on improvement of cognitive function by ameliorating dysfunction of cerebral vessels and increasing neurogenesis in aged DM rats, respectively

Use acupuncture to relieve perimenopausal syndrome: study protocol of a randomized controlled trial

Law Number 11 / 2008 on Information and Electronic Transaction (UU ITE) is the regulation concerning on criminal law in addition to the Criminal Code (KUHP). UU ITE is commonly regarded additional regulation of the Criminal Code as a special law (lex specialis) in which Penal Code is deemed as lex generalis. It is based on the principle of lex specialis derogate legi generalis. This article uses legal research to review the decision of District Court in Bandung Number 1033/PID.B/2014/PN.BDG where it comprises legislation and cases. It concludes that the judge is not frugal in applying the principle lex specialis derogat legi generalis in the consideration. This is associated with the indictment of public prosecutor which only prejudges with article 303 paragraph (1) to 2. In contrast, the indictment which does not meet the requirement of a careful, clear, and complete description asserts to become void by law. Keywords: Online Gambling, Criminal Principle, Indictmen