2,285 research outputs found
Implications of avoiding overlap between training and testing data sets when evaluating genomic predictions of genetic merit
Sensitivity analysis in a market with memory
A general market model with memory is considered in terms of stochastic
functional differential equations. We aim at representation formulae for the
sensitivity analysis of the dependence of option prices on the memory. This
implies a generalization of the concept of delta.Comment: Withdrawn by the authors due to an error in equation (2.6). A new
work is in preparatio
BlogForever D2.6: Data Extraction Methodology
This report outlines an inquiry into the area of web data extraction, conducted within the context of blog preservation. The report reviews theoretical advances and practical developments for implementing data extraction. The inquiry is extended through an experiment that demonstrates the effectiveness and feasibility of implementing some of the suggested approaches. More specifically, the report discusses an approach based on unsupervised machine learning that employs the RSS feeds and HTML representations of blogs. It outlines the possibilities of extracting semantics available in blogs and demonstrates the benefits of exploiting available standards such as microformats and microdata. The report proceeds to propose a methodology for extracting and processing blog data to further inform the design and development of the BlogForever platform
Fandubbing across time and space. From dubbing âby fans for fansâ to cyberdubbing
This chapter investigates a phenomenon that has received scant academic attention so far: fandubbing. To understand the extent and impact of this participatory practice in the current landscape, the chapter examines fandubbing origins and reflects on the needs met by fandubs at different times and contexts. The plethora of uses and motivations behind this phenomenon question the suitability of the term fandubbing. Against this backdrop, and drawing on DĂaz-Cintasâs (2018) conception of âcybersubtitlesâ, the chapter advocates using the term cyberdubbing to reflect the wide range of non-traditional online dubbing practices so prevalent nowadays, including parodic and serious dubbings undertaken by fans, Internet users and digital influencers, be them professionals or amateurs
Translating reality TV into Spanish: when fast-food TV challenges AVT conventions
In Spain, as in other countries, reality TV seems to be a pervasive phenomenon, materialised in a myriad of domestic and foreign productions. The latter require interlingual translation, which in most cases takes the form of voice-over translation. Despite the prevalence of reality TV and voice-over translation in Spanish television, both fields are still widely underexplored. This article sets out to bridge this research gap by presenting an exploratory study of the translation of reality TV in Spain. To this end, it will first document the prevalence of foreign reality TV in Spanish TV schedules, to then explore the similarities and differences in traditional voice-over translation (i.e. used for documentary translation) versus voice-over translation for reality TV. The focus is on the different types of synchrony observed in voice-over translation, yet the discussion highlights other relevant issues (e.g. approaches to the translation of semi-spontaneous speech) and illustrates how this genre is challenging audiovisual translation (AVT) conventions, as well as blurring the boundaries between AVT modes
Calculation of multiple-trait sire reliability for traits included in a dairy cattle fertility index
The advent of genetic evaluations for fertility traits in the UK offers valuable information to farmers that can be used to control fertility problems and safeguard against involuntary culling. In addition to estimated genetic merit, proof reliabilities are required to make correct use of this genetic information. Exact reliabilities, based on the inverse of the coefficient matrix, cannot be estimated for large data sets because of computational restrictions. A method to calculate approximate reliabilities was implemented based on a six-trait sire model. Traits considered were interval between first and second calving, interval between first calving and first service, non-return rate 56 days post first service, number of inseminations per conception, daily milk yield at test nearest day 110 and body condition score. Sire reliabilities were calculated in four steps. Firstly, the number of effective daughters was calculated for each bull, separately for each trait, based on total number of daughters and daughter distribution across herd-year-seasons. Secondly, multiple-trait reliabilities were calculated, based on bull daughter contribution, applying selection index theory on independent daughter groups. Thirdly, (great-) grand-daughter contribution was added to the reliability of each bull, using daughter-based reliability of sons and maternal grandsons. An adjustment was made to account for the probability of bull and son or grandson having daughters in the same herd-year-season. Without the adjustment, reliabilities were inflated by proportionately 0·15 to 0·25. Finally, parent (sire and maternal grandsire) contribution was added to the reliability of each bull. The procedure was first tested on a data subset of 28 061 cow records from 285 bulls. Approximate reliabilities were compared with exact estimates based on the inverse of the coefficient matrix. Mean absolute differences ranged from 0·014 to 0·020 for the six traits and correlation between exact and approximate estimates neared unity. In a full-scale application, sire reliability for the fertility traits increased by proportionately 0·47 to 0·79 over single-trait estimates and the number of bulls with a reliability of 0·60 or more increased by 42 to 115%
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein
A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) variant of α1-antitrypsin as antigen-whose native state is susceptible to the formation of a proto-oligomeric intermediate-we have produced a mAb (5E3) that increases the rate of oligomerization of the wild-type (M) variant. Employing ELISA, gel shift, thermal stability and FRET time-course experiments, we show that mAb5E3 does not bind to the native state of α1-antitrypsin, but recognizes a cryptic epitope in the vicinity of the post-helix A loop and strand 4C that is revealed upon transition to the polymerization intermediate, and which persists in the ensuing oligomer. This epitope is not shared by loop-inserted monomeric conformations. We show the increased amenity to polymerization by either the pathogenic E342K mutation or the binding of mAb5E3 occurs without affecting the energetic barrier to polymerization. As mAb5E3 also does not alter the relative stability of the monomer to intermediate, it acts in a manner similar to the E342K mutant, by facilitating the conformational interchange between these two states
Nature of the spin-glass phase at experimental length scales
We present a massive equilibrium simulation of the three-dimensional Ising
spin glass at low temperatures. The Janus special-purpose computer has allowed
us to equilibrate, using parallel tempering, L=32 lattices down to T=0.64 Tc.
We demonstrate the relevance of equilibrium finite-size simulations to
understand experimental non-equilibrium spin glasses in the thermodynamical
limit by establishing a time-length dictionary. We conclude that
non-equilibrium experiments performed on a time scale of one hour can be
matched with equilibrium results on L=110 lattices. A detailed investigation of
the probability distribution functions of the spin and link overlap, as well as
of their correlation functions, shows that Replica Symmetry Breaking is the
appropriate theoretical framework for the physically relevant length scales.
Besides, we improve over existing methodologies to ensure equilibration in
parallel tempering simulations.Comment: 48 pages, 19 postscript figures, 9 tables. Version accepted for
publication in the Journal of Statistical Mechanic
Influence of the collision energy on the O(1D) + RH --> OH(X2Pi) + R (RH=CH4, C2H6, C3H8) Reaction Dynamics. A laser Induced Fluorescence and Quasiclassical Trajectory Study
The influence of the collision energy (ET) on the O(1D) + RH OH(X2H) + R (RH = CH4, C2H6, and C3H8) reaction dynamics has been studied, using the N2O photodissociation at 193 nm as O(1D) precursor (ET = 0.403 eV) and probing the OH v = 0 and 1 levels by LIF. A triatomic QCT study of the reaction with CH4 on a fully ab initio based analytical PES has also been performed, and a quite good agreement with the experimental OH rovibrational distributions has been obtained. Our experimental results are similar to those obtained when the O3 photodissociation is used to produce O(1D) (ET = 0.212 eV), as expected on the basis of the available energy in products and also from the QCT calculations. The P(v=0)/P(v= 1) populations ratio values reported for C2H6 and C3H8 in a very recent work (Wada and Obi, J. Phys. Chem. A 1998, 102, 3481), where the N2O was also used to generate O(1D), are probably largely underestimated. The rotational distributions obtained are similar to those obtained in other experiments, and a quite good agreement has been obtained for the spin-orbit and A-doublet populations. The reaction takes place near exclusively through the insertion of the O(1D) atom into a C-H bond below 0.6 eV, and the mechanism may be direct or nondirect (mainly through short-lived (CH3)OH collision complexes) with about the same probability. The OH vibrational distribution arising from the direct mechanism is inverted, while the nondirect one leads to a noninverted distribution. At higher ET, the abstraction mechanism also contributes appreciably to reactivity. © 2000 American Chemical Society
Genomic selection: the option for new robustness traits?
Genomic selection is rapidly becoming the state-of-the-art genetic selection methodology in dairy cattle breeding schemes around the world. The objective of this paper was to explore possibilities to apply genomic selection for traits related to dairy cow robustness. Deterministic simulations indicate that replacing progeny testing with genomic selection may favour genetic response for production traits at the expense of robustness traits, owing to a disproportional change in accuracies obtained across trait groups. Nevertheless, several options are available to improve the accuracy of genomic selection for robustness traits. Moreover, genomic selection opens up the opportunity to begin selection for new traits using specialised reference populations of limited size where phenotyping of large populations of animals is currently prohibitive. Reference populations for such traits may be nucleus-type herds, research herds or pooled data from (international) research experiments or research herds. The RobustMilk project has set an example for the latter approach, by collating international data for progesterone-based traits, feed intake and energy balance-related traits. Reference population design, both in terms of relatedness of the animals and variability in phenotypic performance, is important to optimise the accuracy of genomic selection. Use of indicator traits, combined with multi-trait genomic prediction models, can further contribute to improved accuracy of genomic prediction for robustness traits. Experience to date indicates that for newly recorded robustness traits that are negatively correlated with the main breeding goal, cow reference populations of =10 000 are required when genotyping is based on medium- or high-density single-nucleotide polymorphism arrays. Further genotyping advances (e.g. sequencing) combined with post-genomics technologies will enhance the opportunities for (genomic) selection to improve cow robustness
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