Spheroidization in tool steels

A carbon steel, W1, and four other alloy tool steels, namely, A2, H13, D3, and M2, were spheroidized by five different procedures. Any modification made in the treatments for an individual steel were suggested by the results obtained with these five procedures. The hardnesses and microstructures obtained were compared with steel samples annealed at a tool steel mill. The response given by different steels to various methods of spheroidization was studied. It was found that A2, W1, and D3 steels responded the best to the cycling method whereas the best response to the isothermal annealing was given by H13 and M2 steels. The effect of neutron irradiation on the spheroidization of W1 steel was studied and it was concluded that the radiation damage in W1 steel did not affect the rate of spheroidization --Abstract, page ii

Formulation Design and Optimization of Sustained Release Tablet of Ambroxol hydrochloride

A sustained release matrix formulation for Ambroxol hydrochloride was designed and developed to achieve a 12 h release profile. Using HPMC K15M and Eudragit RSPO as an inert matrix forming agent to control the release of Ambroxol hydrochloride. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type I- Basket) at       37±0.5°C and 100 rpm speed. A 32 full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and Eudragit RSPO (X2) were selected as independent variables, where as initial release at the 2 hrs (Y1, % drug release), release rate at the 8 hrs (Y2,   % drug release) and the concentration of Ambroxol hydrochloride released in 12 hrs (Y3, % drug release) were chosen as dependent variables. The optimized formulation F4 follows Hixon Croswell order release kinetics with non-Fickian diffusion mechanism. From the study, it was concluded that the release of Ambroxol hydrochloride can be effectively sustained using combination of HPMC K15M and Eudragit RSPO

Scientific Publications of Shivaji University, Kolhapur (1989-2018): a Scientometric Study

The study is relies uponthe scientific publications published by theShivaji University, Kolhapur (1989-2018). The data collected from the Web of Science. The analysis includes yearly output of research productivity. The study focuses on Author Productivitypattern, types of documents/records, individual author’s research productivity and their TLCS (Total Local Citation Score), TGCS (Total Global Citation Score) TLCR (Total Local Citation References) and TLCSb (Total Local Citation Score in the beginning), H-index and citation count of core contributors, Journal Publications, geographical collaboration of authors (countries of contributing authors) and distribution of research output by language

EMPLOYEES PERCEPTION OF WORKPLACE MONITORING AND SURVEILLANCE

Employee monitoring has gained importance from different interest groups – Commercial organisations, employee interest groups, privacy advocates, professional ethicists and lawyers. It is a practice of organizational management. It is about surveying the employee’s activity through various surveillance methods. The objectives of employee monitoring can be performance tracking, avoiding legal liability, protection of trade secrets and also to focus security concerns if any. The policy of monitoring and surveillance is likely to have a negative effect on employee satisfaction and employee privacy though, it is essential to identify and prevent unacceptable behaviour of employees if any. Employee monitoring trend has evolved gradually as a result of technological innovation. This research paper analyses the impact of employee monitoring practices in organisations. The study proposes organizational theories, privacy theories, control theories and resource theories so as to address the employee privacy issues. These multiple theories indicate multiple dimensions focusing on the proactive approach or a backup plan mediating between organisational policy and behaviour of employees. Result of the study indicates that Employee Commitment level dependents on employee’s perception about their privacy at workplace. This perception is influenced by management practices such as organisational policy and prevention of misuse

Improved Dissolution Rate of Leflunomide using Hydroxypropyl-β-Cyclodextrin Inclusion Complexation by Freeze-Drying Method

Inclusion complexes between leflunomide, a poorly water soluble antirheumatic drug, and HP-β-cyclodextrin (HP-β-CD) were used to improve the solubility and dissolution rate of the drug. Leflunomide forms an inclusion complex with HP-β-CD both in aqueous and in solid state. Phase solubility profile indicated that the solubility of leflunomide significantly increased in the presence of HP-β-CD and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes in aqueous medium. The solid complexes prepared by different methods such as physical mixture, co-grinding method and freeze dried method in 1:1 and 1:2 molar ratio, were characterized by differential scanning calorimetry (DSC) and X-RD. The dissolution profiles of solid complexes were determined and compared with leflunomide alone and their physical mixture, different mediums such as simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4). The dissolution studies showed that, the freeze-dried complex exhibited higher dissolution rates than the drug, in the simulated gastric fluid (SGF pH 1.2) in 1:2 molar ratio

Web Page Annotation Using Web Usage Mining and Domain Knowledge Ontology

Today’s world the growth of the WWW has increased tremendously, the user is totally relying on web for information. Search engine provides the result pages to the user but all are not relevant so the challenging task is extracting the pages from web and provide to the user. WUM is an approach to extract knowledge and use it to the different purposes. In this paper new semantic approach is proposed based on WUM and Domain Knowledge Ontology. Ontology database preparation, it is also challenging task in this project

Promoting the proper use of medicines in rural school children of India

Background: The problem of irrational use of medicines is prevalent in rural India. For safe and proper use of medicines there is a need to understand the proper way of taking medicines. Teaching proper use of medicines is the most neglected domain of the school health curriculum. So this study targeted school going children in rural area of India as the earlier the intervention, the more firmly longer lasting health related behavior can be successfully inculcated. The objectives of the study were (1) To study base level knowledge about use of medicines and (2) To implement and see the effect of an intervention to increase medicine knowledge in the form of information, education and communication (IEC) in rural school children.Methods: This was an interventional, questionnaire based (quantitative) study in which an intervention in the form of lectures which was given to school children. Rural school going children in age group of13-15 years were selected from 3 different schools of rural areas of Nagpur district, India. 500 school children were included after obtaining permission from school authorities and informed consent from their parents. Pretesting done by administering a questionnaire containing 20 questions to assess children's base level knowledge about medicine use. The same questionnaire was repeated on 16th and 45th day of intervention i.e. daily lectures of 25-30 minutes for 15 days on proper use of medicines, to judge the improvement.Results: It was observed that the interventions brought about a positive change in the knowledge of the students as well as increased awareness about proper use of medicines.Conclusions: This study showed that properly timed and meticulously implemented intervention can bring about a positive change in the attitude and knowledge of school children

Anti-hyperalgesic effect of paracetamol in rat model of thermal hyperalgesia: implications for the treatment of neuropathic pain

Background: Neuropathic pain conditions are prevalent in general population and difficult to treat. Most currently available therapies do not provide adequate benefit in all treated patients. Though Paracetamol is available for more than 100 years and have huge safety data, it is still not included in any treatment guidelines for neuropathic pain, as very few studies have evaluated its effects in neuropathic pain conditions. The aim of this study was to evaluate antihyperalgesic activity of paracetamol and to compare it with antihyperalgesic effect of amitriptyline and gabapentin in rat model of thermal hyperalgesia.Methods: Male albino wistar rats weighing 200-250 g of body weight and 4-6 months old were used. After anaesthetizing rats with 2% halothane, mild thermal injury was induced using hot plate analgesiometer. Drugs were administered intraperitoneally 30 minutes after thermal injury. Paw withdrawal latencies were measured at 30, 60, 90 and 120 minutes after drug administration. Statistical analysis done using GraphPad Prism version 5.01 and one way ANOVA followed by post hoc Dunnett's test or Tukey's test were used.Results: Paracetamol showed both dose as well as time dependent antihyperalgesic activity. Gabapentin demonstrated significantly more antihyperalgesic activity compared to amitriptyline (p< 0.05) and paracetamol (p< 0.01).Conclusions: Paracetamol showed antihyperalgesic activity however, it was less as compared to drugs like gabapentin and amitriptyline. Considering the excellent safety profile of paracetamol, it might be useful adjuvant drug for treatment of neuropathic pain conditions