Aeolian-fluvial dryland systems; BSRG Core Workshop

Interpretation of core material can be a complicated process, in part due to the one dimensional nature of the sample, and the limited spatial availability of core; caused by both the limited spatial sampling frequency (distribution of wells with core intersecting the interval of interest) and limited temporal sampling (limited number of core runs recovering material from the interval of interest). To interpret core effectively requires a good understanding of both spatial and temporal variations that can occur within a depositional environment, but also requires the interpreter to know limitations and pitfalls with observing and interpreting the core. The Permian Leman Sandstone is the preserved expression of a mixed fluvial – aeolian succession, deposited by a fluvial system which terminated in a desert basin. The fluvial system which originated from the London-Brabant Massif, and flowed NNE into the south western edge of the South Permian Basin, which was occupied by an aeolian erg field along the southern margin and sabkahas and playa lakes toward the basin centre. The interactions between the fluvial system and the dune field lead to the deposition of a hybrid stratigraphy, where episodic fluvial activity would rework and entrain material from aeolian deposits, before later being reworked themselves by ongoing aeolian processes. This workshop aims to familiarise participants with the expression of fluvial and aeolian strata in core, and to understand the potential pitfalls and limitations with these interpretations. Key aims of this core workshop are to: · Familiarise the participants with identifying key aeolian and fluvial facies in core. · Identifying the processes which formed these faces. · Using facies associations and successions to build depositional models. · Understand pitfalls and limitations with interpretation of core materials

MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas

In view of the certain anatomic site-dependent frequency of chromosomal translocations involved in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were analyzed for MALT1 and FOXP1 translocations. B cell CLL/lymphoma 10 (BCL10) and forkhead box PA (FOXP1) protein expression were studied by immunohistochemistry and translocations identified using fluorescence in situ hybridization (FISH)-specific probes FOXP1, t(11;18)(q21;q21)/API2-MALT1 and t(14;18)(q32;q21)/IgH-MALT1. None of the 11 analyzed cases showed FOXP1 rearrangement or amplification. The t(11;18) was present in five of 13 cases and the t(14;18) in three of 13 cases. MALT1 translocations were mostly mutually exclusive except in a single case. FOXP1 protein expression showed differences in the proportion of tumor cells with nuclear expression but not in their intensity, with the exception of one case where very intense nuclear staining was noted. BCL10 nuclear expression was present in four of 17 cases, two of which lacked t(11;18). Our results suggest that MALT1-specific translocations and FOXP1 rearrangements are not commonly involved in pathogenesis. A case with strong FOXP1 protein expression indicates the possibility that the upregulation of FOXP1 expression is significant in a small subset of salivary gland MALT lymphomas. Also a single case in which both MALT1 translocations were present indicates that these are not always mutually exclusive

A review of fingerprint recovery within an arson crime scene

Fingerprints have been used in criminal investigations in the United Kingdom since 1902. Many advances in research and technology have improved current opportunities for fingerprint recovery at crime scenes. Possibly due to the lack of training and research, the recoverability of fingerprints in a fire scene are undervalued and misunderstood. There is a widespread misconception that fire will destroy all fingerprint evidence. Evaluation of current literature available has shown that fingerprints can indeed be recovered with excellent results. Fire scenes, in particular deliberate or arson, can be examined with reference to the elevated temperature conditions at each stage and the understanding of the soot removal techniques is paramount to the investigation process. Further research is required to make advancement in fire scene fingerprint recovery

The diagnosis and treatment of wounds in the old English medical collections: Anglo-Saxon surgery?

This volume brings together essays that consider wounding and/or wound repair from a wide range of sources and disciplines including arms and armaments, military history, medical history, literature, art history, hagiography, and archaeology across medieval and early modern Europe

Predicting sleep disordered breathing in outpatients with suspected OSA

Objective To validate the utilities of Berlin, STOP and STOP-BANG Questionnaires, other patient characteristics, comorbidities, Epworth Sleepiness Scale (ESS), fractional exhaled nitric oxide (FENO) and blood markers for the prediction of sleep disordered breathing (SDB) on limited polygraphy. Setting North Glasgow Sleep Service (a tertiary referral centre). Participants 129 consecutive patients, aged ≥16 years, referred to the sleep clinic for assessment of possible obstructive sleep apnoea. Interventions We selected cut-points of apnoea hypopnoea index (AHI) of ≥5 and ≥15/h from their home polygraphy and determined associations of these with individual symptoms, questionnaire scores and other results. Receiver operating characteristic analysis and univariate and multivariate logistic regression were used to explore these. Primary and secondary outcomes measures Primary: The utility of STOP, STOP-BANG and Berlin Questionnaires for prediction of SDB. Secondary: The utility of other measures for prediction of SDB. Results AHI was ≥5 in 97 patients and ≥15 in 56 patients. STOP and STOP-BANG scores were associated with both AHI cut-points but results with ESS and Berlin Questionnaire scores were negative. STOP-BANG had a negative predictive value 1.00 (0.77–1.00) for an AHI ≥15 with a score ≥3 predicting AHI ≥5 with sensitivity 0.93 (95% CI 0.84 to 0.98) and accuracy 79%, while a score ≥6 predicted AHI ≥15 with specificity 0.78 (0.65 to 0.88) and accuracy 72%. Neck circumference ≥17 inch and presence of witnessed apnoeas were independent predictors of SDB. Conclusions STOP and STOP-BANG Questionnaires have utility for the prediction of SDB in the sleep clinic population. Modification of the STOP-BANG Questionnaire merits further study in this and other patient groups.</p