1,331 research outputs found
QoE in IoT: a vision, survey and future directions
\ua9 The Author(s) 2021. The rapid evolution of the Internet of Things (IoT) is making way for the development of several IoT applications that require minimal or no human involvement in the data collection, transformation, knowledge extraction, and decision-making (actuation) process. To ensure that such IoT applications (we term them autonomic) function as expected, it is necessary to measure and evaluate their quality, which is challenging in the absence of any human involvement or feedback. Existing Quality of Experience (QoE) literature and most QoE definitions focuses on evaluating application quality from the lens of human receiving application services. However, in autonomic IoT applications, poor quality of decisions and resulting actions can degrade the application quality leading to economic and social losses. In this paper, we present a vision, survey and future directions for QoE research in IoT. We review existing QoE definitions followed by a survey of techniques and approaches in the literature used to evaluate QoE in IoT. We identify and review the role of data from the perspective of IoT architectures, which is a critical factor when evaluating the QoE of IoT applications. We conclude the paper by identifying and presenting our vision for future research in evaluating the QoE of autonomic IoT applications
Terahertz underdamped vibrational motion governs protein-ligand binding in solution
Low-frequency collective vibrational modes in proteins have been proposed as being responsible for efficiently directing biochemical reactions and biological energy transport. However, evidence of the existence of delocalized vibrational modes is scarce and proof of their involvement in biological function absent. Here we apply extremely sensitive femtosecond optical Kerr-effect spectroscopy to study the depolarized Raman spectra of lysozyme and its complex with the inhibitor triacetylchitotriose in solution. Underdamped delocalized vibrational modes in the terahertz frequency domain are identified and shown to blue-shift and strengthen upon inhibitor binding. This demonstrates that the ligand-binding coordinate in proteins is underdamped and not simply solvent-controlled as previously assumed. The presence of such underdamped delocalized modes in proteins may have significant implications for the understanding of the efficiency of ligand binding and proteinâmolecule interactions, and has wider implications for biochemical reactivity and biological function
Scalar-field Pressure in Induced Gravity with Higgs Potential and Dark Matter
A model of induced gravity with a Higgs potential is investigated in detail
in view of the pressure components related to the scalar-field excitations. The
physical consequences emerging as an artifact due to the presence of these
pressure terms are analysed in terms of the constraints parting from energy
density, solar-relativistic effects and galactic dynamics along with the dark
matter halos.Comment: 26 pages, 3 figures, Minor revision, Published in JHE
A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
<p>Abstract</p> <p>Background</p> <p>To test the hypothesis that modulation of Bcl-2 with 13-cis retinoic acid (CRA)/interferon-alpha2b (IFN) with paclitaxel (TAX), or mitoxantrone, estramustine and vinorelbine (MEV) will have clinical activity in men with metastatic castrate-resistant prostate cancer (CRPC).</p> <p>Methods</p> <p>70 patients were treated with either MEV (Arm A) in a 3-week cycle or CRA/IFN/TAX with an 8-week cycle (Arm B). Patients were assessed for response, toxicity, quality of life (QOL), and the effect of treatment on Bcl-2 levels in peripheral blood mononuclear cells (PBMC).</p> <p>Results</p> <p>The PSA response rates were 50% and 23%, measurable disease response rates (CR+PR) 14% and 15%, and median overall survival 19.4 months and 13.9 months on Arm A and Arm B respectively. Transient grade 4 neutropenia occurred in 18 and 2 patients, and grade 3 to 4 thrombosis in 7 patients and 1 patient in Arm A and Arm B respectively. Patients on Arm B reported a clinically significant decline in QOL between baseline and week 9/10 (.71 s.d.), and a significantly lower level of QOL than Arm A (p = 0.01). As hypothesized, Bcl-2 levels decreased with CRA/IFN therapy only in Arm B (p = 0.03).</p> <p>Conclusions</p> <p>Treatment with MEV was well tolerated and demonstrated clinical activity in patients with CRPC. Given the adverse effect of CRA/IFN/TAX on QOL, the study of other novel agents that target Bcl-2 family proteins is warranted. The feasibility of measuring Bcl-2 protein in a cooperative group setting is hypothesis generating and supports further study as a marker for Bcl-2 targeted therapy.</p> <p>Trial Registration</p> <p><b>Clinical Trials Registration number</b>: CDR0000067865</p
Autoimmune and autoinflammatory mechanisms in uveitis
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult; clinically, inflammation following such an insult is termed uveitis. The intra-ocular inflammation in uveitis may be clinically obvious as a result of infection (e.g. toxoplasma, herpes), but in the main infection, if any, remains covert. We now recognise that healthy tissues including the retina have regulatory mechanisms imparted by control of myeloid cells through receptors (e.g. CD200R) and soluble inhibitory factors (e.g. alpha-MSH), regulation of the blood retinal barrier, and active immune surveillance. Once homoeostasis has been disrupted and inflammation ensues, the mechanisms to regulate inflammation, including T cell apoptosis, generation of Treg cells, and myeloid cell suppression in situ, are less successful. Why inflammation becomes persistent remains unknown, but extrapolating from animal models, possibilities include differential trafficking of T cells from the retina, residency of CD8(+) T cells, and alterations of myeloid cell phenotype and function. Translating lessons learned from animal models to humans has been helped by system biology approaches and informatics, which suggest that diseased animals and people share similar changes in T cell phenotypes and monocyte function to date. Together the data infer a possible cryptic infectious drive in uveitis that unlocks and drives persistent autoimmune responses, or promotes further innate immune responses. Thus there may be many mechanisms in common with those observed in autoinflammatory disorders
The stellar and sub-stellar IMF of simple and composite populations
The current knowledge on the stellar IMF is documented. It appears to become
top-heavy when the star-formation rate density surpasses about 0.1Msun/(yr
pc^3) on a pc scale and it may become increasingly bottom-heavy with increasing
metallicity and in increasingly massive early-type galaxies. It declines quite
steeply below about 0.07Msun with brown dwarfs (BDs) and very low mass stars
having their own IMF. The most massive star of mass mmax formed in an embedded
cluster with stellar mass Mecl correlates strongly with Mecl being a result of
gravitation-driven but resource-limited growth and fragmentation induced
starvation. There is no convincing evidence whatsoever that massive stars do
form in isolation. Various methods of discretising a stellar population are
introduced: optimal sampling leads to a mass distribution that perfectly
represents the exact form of the desired IMF and the mmax-to-Mecl relation,
while random sampling results in statistical variations of the shape of the
IMF. The observed mmax-to-Mecl correlation and the small spread of IMF
power-law indices together suggest that optimally sampling the IMF may be the
more realistic description of star formation than random sampling from a
universal IMF with a constant upper mass limit. Composite populations on galaxy
scales, which are formed from many pc scale star formation events, need to be
described by the integrated galactic IMF. This IGIMF varies systematically from
top-light to top-heavy in dependence of galaxy type and star formation rate,
with dramatic implications for theories of galaxy formation and evolution.Comment: 167 pages, 37 figures, 3 tables, published in Stellar Systems and
Galactic Structure, Vol.5, Springer. This revised version is consistent with
the published version and includes additional references and minor additions
to the text as well as a recomputed Table 1. ISBN 978-90-481-8817-
New Higgs interactions and recent data from the LHC and the Tevatron
We perform a multi-parameter global analysis of all data available till date
from the ATLAS, CMS and Tevatron experiments, on the signals of a Higgs boson,
to investigate how much scope exists for departure from the standard model
prediction. We adopt a very general and model-independent scenario, where
separate deviations from standard model values are possible for couplings of
the observed scalar with up-and down-type fermions, W-and Z-boson pairs, as
well as gluon and photon pair effective interactions. An arbitrary phase in the
coupling with the top-pair, and the provision for an invisible decay width for
the scalar are also introduced. After performing a global fit with seven
parameters, we find that their values at 95% confidence level can be
considerably different from standard model expectations. Moreover, rather
striking implications of the phase in top-quark coupling are noticed. We also
note that the invisible branching ratio can be sizeable, especially when the
couplings of the Higgs to W-and Z-pairs are allowed to be different.Comment: 18 pages, 4 figures; v2: minor additions to tex
Complete Higgs sector constraints on dimension-6 operators
Constraints on the full set of Standard Model dimension-6 operators have previously used triple-gauge couplings to complement the constraints obtainable from Higgs signal strengths. Here we extend previous analyses of the Higgs sector constraints by including information from the associated production of Higgs and massive vector bosons (H+V production), which excludes a direction of limited sensitivity allowed by partial cancellations in the triple-gauge sector measured at LEP. Kinematic distributions in H+V production provide improved sensitivity to dimension-6 operators, as we illustrate here with simulations of the invariant mass and pT distributions measured by D0 and ATLAS, respectively. We provide bounds from a global fit to a complete set of CP-conserving operators affecting Higgs physics
Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome.
iskott-Aldrich syndrome (WAS) is an inherited immunodeficiency caused by mutations in the
gene encoding WASP, a protein regulating the cytoskeleton. Hematopoietic stem/progenitor
cell (HSPC) transplants can be curative, but, when matched donors are unavailable, infusion of
autologous HSPCs modified ex vivo by gene therapy is an alternative approach. We used a lentiviral
vector encoding functional WASP to genetically correct HSPCs from three WAS patients and
reinfused the cells after a reduced-intensity conditioning regimen. All three patients showed
stable engraftment of WASP-expressing cells and improvements in platelet counts, immune
functions, and clinical scores. Vector integration analyses revealed highly polyclonal and
multilineage haematopoiesis resulting from the gene-corrected HSPCs. Lentiviral gene therapy
did not induce selection of integrations near oncogenes, and no aberrant clonal expansion was
observed after 20 to 32 months. Although extended clinical observation is required to establish
long-term safety, lentiviral gene therapy represents a promising treatment for WAS
- âŠ